Fatigue in early Parkinson's disease: the Norwegian ParkWest study

Ongre, Solgunn Odinsen; Larsen, Jan Petter; Tysnes, Ole‐Bjørn; Herlofson, Karen

doi:10.1111/ene.13161

Cited by 32 publications

(27 citation statements)

References 28 publications

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“…In case of articles stemmed from the same databases, only the primary (first) of these was included in the meta‐analysis to prevent a disproportional influence of some databases on overall estimate.…”

Section: Methodsmentioning

confidence: 99%

Fatigue in Parkinson's disease: A systematic review and meta‐analysis

et al. 2018

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We conducted a systematic review and meta‐analysis aimed at establishing robust prevalence estimates and identifying clinical correlates of fatigue in PD. From 2,459 titles and abstracts, we selected 44 relevant studies (n = 7427 patients). Overall, the meta‐analysis showed a prevalence of fatigue of 50% in PD. This prevalence estimate, however, was significantly moderated by study heterogeneity in measurement scales and cut‐off thresholds. In contrast, demographic features, disease severity, cognitive impairment, and depression did not moderate prevalence estimates. Moreover, fatigue prevalence did not differ between de novo and treated PD patients. Compared to nonfatigued patients, fatigued patients had sligthly higher age (1.44 years), disease duration (0.93 years), l‐dopa equivalent daily dose (50.89 units), UPDRS‐III (4.99 points), and H & Y (0.33 points), as well as risk of comorbid depression (risk ratio = 1.89) and had a little lower MMSE score (–0.66 points). Fatigue was moderately associated with apathy (Hedges' g = 0.55), anxiety (Hedges' g = 0.67), daytime somnolence (Hedges' g = 0.43), sleep disturbances (Hedges' g = 0.66), and poorer quality of life (Hedges' g = 1.23). Our analyses suggest that fatigue is a frequent, independent nonmotor symptom in PD appearing early and persisting throughout the disease course, and that establishing uniform diagnostic criteria for PD‐related fatigue is critical. In addition, several nonmotor symptoms appear to be associated with fatigue and negatively impact quality of life. Pharmacological and nonpharmacological interventions targeting fatigue and associated symptoms may improve quality of life in patients with PD. © 2018 International Parkinson and Movement Disorder Society

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Section: Methodsmentioning

confidence: 99%

Fatigue in Parkinson's disease: A systematic review and meta‐analysis

et al. 2018

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“…Concerning the diffusion of the different criteria, the UKPDSBB criteria have been widely employed in both clinical trials and routine clinical practice around the world, whereas, to the best of our knowledge, only a small number of clinical studies (mainly carried out in the US and in Scandinavia) have adopted Gelb criteria ( 26 – 33 ), somehow justifying their more limited diffusion among practicing clinicians. Calne criteria and Larsen criteria have been used even less.…”

Section: Diagnostic Accuracy Of Different Sets Of Criteriamentioning

confidence: 99%

Diagnostic Criteria for Parkinson’s Disease: From James Parkinson to the Concept of Prodromal Disease

2018

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The diagnosis of Parkinson’s disease (PD) is based on clinical features and differently to the common opinion that detecting this condition is easy, seminal clinicopathological studies have shown that up one-fourth of patients diagnosed as PD during life has an alternative diagnosis at postmortem. The misdiagnosis is even higher when only the initial diagnosis is considered, since the diagnostic accuracy improves by time, during follow-up visits. Given that the confirmation of the diagnosis of PD can be only obtained through neuropathology, to improve and facilitate the diagnostic–therapeutic workup in PD, a number of criteria and guidelines have been introduced in the last three decades. In the present paper, we will critically re-appraise the main diagnostic criteria proposed for PD, with particular attention to the recently published criteria by the International Parkinson and Movement Disorder Society (MDS) task force, underlying their novelty and focusing on the diagnostic issues still open. We also emphasize that the MDS-PD criteria encompass the two main previous sets of diagnostic criteria (United Kingdom PD Society Brain Bank and Gelb’s criteria), introducing at the same time new aspects as the use of non-motor symptoms as additional diagnostic features, and the adoption of the concept of prodromal PD, crucial to enroll in clinical trials PD patients in the very early phase of the disease. To better understand the real diffusion of the new MDS-PD diagnostic criteria among neurologists, we have also collected selective opinions of sixteen movement disorder experts from various world regions on their practical approach for the clinical diagnosis of PD. Results from this brief survey showed that, although innovative and complete, the revised diagnostic criteria produced by MDS task force are still scarcely employed among clinicians. We believe that both national and international scientific societies should operate in the future for a broader diffusion of these criteria with specific initiatives, including dedicated events and teaching courses.

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“…The effects of dopaminergic agonists on fatigue are uncertain, and fatigue may even be an adverse effect of this type of medication . However, one study showed that treatment‐naïve patients had lower levels of fatigue after 1 year of treatment and that patients using dopaminergic agonists had greater benefit than those taking levodopa …”

Section: Treatmentmentioning

confidence: 99%

Fatigue in Parkinson's disease: concepts and clinical approach

Nassif

Pereira

2018

Psychogeriatrics

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Parkinson's disease (PD) is a progressive neurological disorder characterized by a large number of motor and non-motor features. Fatigue is one of the most common and most disabling symptoms among patients with PD, and it has a significant impact on their quality of life. Although fatigue has been recognized for a long time, its pathophysiology remains poorly understood, and there is no evidence to support any therapeutic approach in PD patients. Expert consensus on case definition and diagnostic criteria for PD-related fatigue have been recently published, and although they still need to be adequately validated, they provide a great step forward in the study of fatigue. The goal of this article is to provide relevant information for the identification and management of patients with fatigue.

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Fatigue in early Parkinson's disease: the Norwegian ParkWest study

Cited by 32 publications

References 28 publications

Fatigue in Parkinson's disease: A systematic review and meta‐analysis

Fatigue in Parkinson's disease: A systematic review and meta‐analysis

Diagnostic Criteria for Parkinson’s Disease: From James Parkinson to the Concept of Prodromal Disease

Fatigue in Parkinson's disease: concepts and clinical approach

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