Fatigue in knee and hip osteoarthritis: the role of pain and physical function

Snijders, G.F.; Ende, C.H.M. van den; Fransen, Jaap; Riel, P. L. C. M. van; Stukstette, M.J.; Defoort, Koen C.; Arts-Sanders, M. A.; Hoogen, F.H.J. van den; Broeder, Alfons A den

doi:10.1093/rheumatology/ker201

Cited by 49 publications

(42 citation statements)

References 30 publications

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“…It is widely known that female have higher morbidity of RA than male, but we found that the incidence and degree of functional disability had no difference in gender. In addition, we found fatigue had no significant relationship with functional disability in regression, which was inconsistent with finding by the previous studies that fatigue was positively related to physical function [42,43]. These findings indicate gender and marital status make no difference in functional disability in southwest Chinese patients.…”

Section: Discussioncontrasting

confidence: 99%

Sociodemographic factors associated with functional disability in outpatients with rheumatoid arthritis in Southwest China

Zhao

Chen

2015

Clin Rheumatol

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With the rising number of patients with rheumatoid arthritis (RA), there is a limited understanding about sociodemographic factors that influence functional disability in Chinese patients. In order to provide more targeted interventions to improve health-related quality of life (HRQoL) for patients with RA, we conducted a cross-sectional study to investigate the level and influencing factors of functional disability. Convenient samples were collected in outpatients with RA from a rheumatological center in southwest China from September to December 2013. Data were collected by printed questionnaires, and functional disability was measured by the Health Assessment Questionnaire Disability Index (HAQ-DI). The results showed that 58.48 % of 607 outpatients had functional disability. Patients from rural residents, with lower household income and lower education level, were significantly associated with worse functional disability. Multivariate regression findings showed that pain, age, disease duration, total cost for treatment, and frequency of hospitalization were positively associated with functional disability. Meanwhile, subjective and available social support was the protective predictors for functional disability. The results suggested that systematic intervention and therapies should be provided as early as possible. Patients and health care providers should promote the awareness of the importance of accessible health education in early intervention of RA. Besides, pain management and social support are encouraged to postpone the process of disability of patients and improve the HRQoL. Lastly, but not least, prevention and intervention of RA should be incorporated into public health education.

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Section: Discussioncontrasting

confidence: 99%

Sociodemographic factors associated with functional disability in outpatients with rheumatoid arthritis in Southwest China

Zhao

Chen

2015

Clin Rheumatol

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“…Similarly, unspecified knee pain was associated with a 4.5-fold increased risk for decline in gait speed over 4 years [ 45 ]. Furthermore, WOMAC pain score was associated with greater physical fatigue, and fatigue was associated with poor physical function [ 35 ]. This may explain why the 20-m walk was not related to constant or intermittent pain, as the test may not be long enough to induce fatigue.…”

Section: Discussionmentioning

confidence: 99%

Intermittent and constant pain and physical function or performance in men and women with knee osteoarthritis: data from the osteoarthritis initiative

et al. 2014

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Severe constant and intermittent knee pain are associated with “unacceptable” symptoms in older adults with osteoarthritis (OA) [ 22 ]. We hypothesized that constant and intermittent pain would be independently related to physical function, with intermittent knee pain being a better predictor of future declines in physical function in early symptomatic knee OA. This study included men (n = 189) and women (n = 133) with radiographic, unilateral knee OA, observed using data from the Osteoarthritis Initiative (OAI). Pain types were measured using the Intermittent and Constant Osteoarthritis Pain (ICOAP) scale. Physical function was measured using the Western Ontario and McMaster Universities Arthritis Index (WOMAC-PF) and Knee Injury and Osteoarthritis Outcome Score (KOOS-FSR) and physical performance tests. High baseline intermittent (B = 0.277; p = 0.001) and constant (B = 0.252; p = 0.001) knee pain were related to poor WOMAC-PF. Increased constant (B = 0.484; p = 0.001) and intermittent (B = 0.104; p = 0.040) pain were related to 2-year decreased WOMAC-PF. High baseline intermittent knee pain predicted poor KOOS-FSR at year 2 (B = −0.357; p = 0.016). Increased constant pain was related to decreased chair stand test performance over 2 years in women (B = 0.077; p = 0.001). High baseline intermittent pain was related to poor performance on repeated chair stands (B = 0.035; p = 0.021), while baseline constant pain was related to poor 400-m walk performance in women (B = 0.636; p = 0.047). Intermittent and constant knee pain were independent factors in self-perceived physical function and were important predictors of future limitations in physical function. Identifying intermittent and constant pain in early symptomatic OA may allow patients to adopt strategies to prevent worsening pain and future declines in physical function.

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“…Based on the distribution of pain VAS scores in patients who described their pain intensity as none, mild, moderate, or severe, the following cut points on the pain VAS were recommended: no pain (0-4 mm), mild pain (5-44), moderate pain (45-74 mm), and severe pain (75-100 mm) [36]. In addition, the patient global assessment of the severity of knee OA, measured on a 0-100 mm VAS, was evaluated where 0 equals no symptoms and higher scores indicating a lower response to therapy (or more severe the disease) [37]. Similar to pain status, patients marked the relevant severity of disease experienced on this line and the value was noted by the investigator, in mm [35].…”

Section: Clinical Status Assessmentmentioning

confidence: 99%

l-Carnitine supplementation improved clinical status without changing oxidative stress and lipid profile in women with knee osteoarthritis

Mahdavi

Kolahi

et al. 2015

Nutrition Research

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Fatigue in knee and hip osteoarthritis: the role of pain and physical function

Cited by 49 publications

References 30 publications

Sociodemographic factors associated with functional disability in outpatients with rheumatoid arthritis in Southwest China

Sociodemographic factors associated with functional disability in outpatients with rheumatoid arthritis in Southwest China

Intermittent and constant pain and physical function or performance in men and women with knee osteoarthritis: data from the osteoarthritis initiative

l-Carnitine supplementation improved clinical status without changing oxidative stress and lipid profile in women with knee osteoarthritis

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