Fatigue in multiple sclerosis and its relationship to depression and                 neurologic disability

Bakshi, Rohit; Shaikh, Zubair A.; Miletich, Robert S.; Czarnecki, Donna; Dmochowski, Jacek; Henschel, K.; Janardhan, Vallabh; Dubey, Neeraj; Kinkel, Peter R.

doi:10.1177/135245850000600308

Cited by 403 publications

(249 citation statements)

References 31 publications

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“…Le- The results of our research coincide with ones of other investigators [19][20][21][22][23]. The major limitation of our work was retrospective character of the study, not allowing correct identification of prognostic factors.…”

Section: Discussionsupporting

confidence: 83%

The Analysis of Relationship Between Lesion of Functional Systems of Nervous System and Severity of Fatigue in Patients With Multiple Sclerosis

Mialovytska

Khyzhniak

2017

EUREKA: Health Sciences

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Despite numerous investigations, fatigue remains one of the least studied manifestations of MS. However, significant prevalence of this symptom proves importance of its study. The aim of the study was to define a prognostic assessment of fatigue development accompanying lesions of certain functional systems and degree of disability. Material and methods. 96 patients, aged 15 to 58 years with a diagnosis of MS have been examined. MS patients were examined with the same protocol, using formalized scales. To detect fatigue and determine the degree of its severity was used Fatigue Severity Scale (FSS). The degree of disability in patients was assessed by Kurtzke EDSS (Expanded Disability Status Scale). Statistical methods for the data analysis were also used, including methods of descriptive statistics, probability assessment and prognostic significance of obtained data using odds ratio (OR). Results. Fatigue was detected in 49.1% of patients with a degree of disability lower than 4 EDSS scores and in 90.4% of patients with disability higher than 4 EDSS scores (p=0.0027). The assessment of functional systems at the time of observation has statistically significant prognostic values according to the following parameters: pyramidal system lesion (OR=7.43 (2.43–22.76)), coordination disorders (OR=4.60 (1.05–20.25)), cranial nerve lesion (OR=4.33 (1.40–13.39)), (p<0.05). Lesion of the pyramidal and coordination systems at the onset of the disease may increase risk for detection of fatigue higher than 4 scores in the follow-up observation (lesion of pyramidal system – OR=1.62 (0.5–5.25), coordination disorders OR=1.41 (0.58–5.16)). Conclusion. The results of our investigation showed that symptom of fatigue is observed in almost 90 % of MS patients. The study showed that fatigue in MS patients depends on the degree of disability and lesions of certain functional systems.

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Section: Discussionsupporting

confidence: 83%

The Analysis of Relationship Between Lesion of Functional Systems of Nervous System and Severity of Fatigue in Patients With Multiple Sclerosis

Mialovytska

Khyzhniak

2017

EUREKA: Health Sciences

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“…While some of them found a positive relationship between physical impairment and physical fatigue [10,11], others could not reveal any relationship [2,4,[12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Impact of fatigue on the efficacy of rehabilitation in multiple sclerosis

et al. 2011

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Fatigue is considered to be one of the most common and disabling symptoms among individuals with multiple sclerosis (MS). The aim of this study is to investigate if an intensive, short-term inpatient rehabilitation program is able to improve fatigue in MS, and if fatigue is able to negatively influence the clinical and functional outcome of rehabilitation in MS. One-hundred eighty six consecutively recruited MS patients underwent an intensive, short-term inpatient rehabilitation program. Sixty-four of them were selected for this study according to our inclusion criteria and compared to a control group of 22 MS patients who did not follow a rehabilitation program. We measured fatigue symptoms with the Fatigue Severity Scale (FSS) before and after rehabilitation, and classified patients into fatigued (FMS) in the case of an FSS score ≥36 and into non-fatigued MS (NFMS) in the case of an FSS <36. Expanded Disability Status Scale (EDSS) and Functional Independence Measure (FIM) were used as clinical outcome measures of the efficacy of the rehabilitation program. In our sample, an intensive, short-term rehabilitation treatment is able to determine a significant reduction of fatigue symptoms compared to untreated MS patients (p < 0.0001); however, the presence of fatigue at the beginning of the rehab program seems not to have any impact on the clinical and functional outcome of rehabilitation. An intensive inpatient rehabilitation trial decreases symptom of fatigue in MS patients; furthermore fatigue seems not to modify the amelioration of disability and impairment determined by a rehabilitation program.

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“…When measuring fatigue, the concept of primary and secondary fatigue must be considered, with fatigue resulting from confounding medical comorbidities such as mobility problems, mood disorders or daytime sleepiness accounting for most 'secondary fatigue' [9]. In particular, depression should be considered as a potentially confounding variable, as a close correlation to fatigue has been described [10]. Furthermore, medication can also affect MS fatigue [11].…”

Section: Introductionmentioning

confidence: 99%

Structural correlates for fatigue in early relapsing remitting multiple sclerosis

et al. 2015

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Fatigue in multiple sclerosis and its relationship to depression and neurologic disability

Abstract: We studied multiple sclerosis fatigue (MSF) and its relationship to depression and disability. Seventy-one patients [50 relapsing-remitting, 21 secondary progressive] were grouped by Fatigue Severity Scale (FSS) into MS-fatigue (MSF) (FSS>/=5; n=46) or MS-nonfatigue (MSNF) (FSS Show more

Cited by 403 publications

References 31 publications

The Analysis of Relationship Between Lesion of Functional Systems of Nervous System and Severity of Fatigue in Patients With Multiple Sclerosis

The Analysis of Relationship Between Lesion of Functional Systems of Nervous System and Severity of Fatigue in Patients With Multiple Sclerosis

Impact of fatigue on the efficacy of rehabilitation in multiple sclerosis

Structural correlates for fatigue in early relapsing remitting multiple sclerosis

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