Fatigue in Myasthenia Gravis Patients

Kittiwatanapaisan, Waraluk; Gauthier, Dorothy K.; Williams, Anne; Oh, Shin J.

doi:10.1097/01376517-200304000-00004

Cited by 30 publications

(44 citation statements)

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“…1,3,17,28,29 In this study, higher levels of experienced fatigue in patients with MG were associated with reduced muscle strength but no difference in muscle fatigue. In patients with MG, a negative correlation between physical activity and fatigue scores was detected in a study by Kittiwatanapaisan et al 17 In that study, the majority of the participants with MG were overweight (BMI !25.0) or obese, which is a common side effect of Table 1. Clinical scales (mean 6 SD).…”

Section: Discussionmentioning

confidence: 64%

“…The MGFS is a Likert scale that contains 26 items addressing 3 subscales of fatigue, including perception of fatigue, task-avoidance behaviors, and observable motor signs associated with fatigue. 17 Potential scores range from 25 to 130, with higher scores indicating greater fatigue. 17 For both items of the VAS, subjects were instructed to quantify their responses by intersecting a 10-cm horizontal line anchored with descriptors at either end.…”

Section: Methodsmentioning

confidence: 99%

“…17 Potential scores range from 25 to 130, with higher scores indicating greater fatigue. 17 For both items of the VAS, subjects were instructed to quantify their responses by intersecting a 10-cm horizontal line anchored with descriptors at either end. The 2 items of the VAS asked subjects to quantify their current level of fatigue and also how their fatigue has impacted their activities of daily living (ADL) within the previous month.…”

Section: Methodsmentioning

confidence: 99%

“…All subjects provided informed written consent, and the study was approved by the Health Sciences Research Ethics Board of the University of Western Ontario. 17 and a 2-item Visual Analog Scale (VAS). The MGFS is a Likert scale that contains 26 items addressing 3 subscales of fatigue, including perception of fatigue, task-avoidance behaviors, and observable motor signs associated with fatigue.…”

Section: Methodsmentioning

confidence: 99%

“…[11][12][13][14] However, although MG is the prototypic fatiguing disorder, few studies have directly measured force to evaluate weakness or fatigue in myasthenia. 15,16 The use of questionnaires 17,18 and surveys, 19,20 in addition to manual muscle testing (MMT), 21,22 have emerged as the preferred tools for assessing weakness and fatigue clinically in MG.…”

Section: Muscle Nerve 41: 362-369 2010mentioning

confidence: 99%

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Muscle strength and fatigue in patients with generalized myasthenia gravis

et al. 2009

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Myasthenia gravis (MG) is characterized by fatigue and fluctuating muscle weakness resulting from impaired neuromuscular transmission (NMT). The objective of this study was to quantify, by direct measurement of muscle force, the strength and fatigue of patients with MG. A maximal voluntary isometric contraction protocol of shoulder abductors was used in conjunction with conventional fatigue and disease-severity instruments. Results from patients with (D-MG) and without (ND-MG) decrement on repetitive nerve stimulation (RNS) of the spinal accessory and axillary nerves were compared with healthy controls. Patients with MG reported greater fatigue than controls. Muscle strength was lowest in the D-MG group, followed by the ND-MG group and controls. Normalized shoulder abduction fatigue and recovery values did not differ between the D-MG and ND-MG groups or controls. The RNS decrement appears to relate best to disease severity and muscle weakness but not to objective measures of fatigue in this population.

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