Fatigue in older adults: an early indicator of the aging process?

Avlund, Kirsten

doi:10.1007/bf03324782

Cited by 186 publications

(177 citation statements)

References 143 publications

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“…Although the concepts of frailty and functional capacity are different, it is necessary to understand the relationship between these two variables (17) . Studies indicate that factors intrinsically linked to frailty, such as low levels of physical activity, fatigue, gait speed, and decreased muscle strength, can be predictors of disability (17)(18) .…”

Section: Discussionmentioning

confidence: 99%

“…Studies indicate that factors intrinsically linked to frailty, such as low levels of physical activity, fatigue, gait speed, and decreased muscle strength, can be predictors of disability (17)(18) . In this study, functional capacity achieved significant results in the three groups (p<0.001), suggesting the importance of maintaining functional capacity, not only in pre-frail and frail older adults, but also in non-frail older adults.…”

Section: Discussionmentioning

confidence: 99%

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Fragilidade e qualidade de vida de idosos usuários da atenção básica de saúde

et al. 2016

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Submission: 04-13-2015Approval: 12-01-2015 ABSTRACT Objective: to investigate the association between physical frailty and quality of life in elderly users of primary health care in the capital of the state of Paraná. Method: a cross-sectional, quantitative study with 203 elders. Data collected included: physical activity questionnaires, weight loss, fatigue/exhaustion, quality of life, performance of gait speed tests, and handgrip strength. Results: of the 203 older adults, 115 were pre-frail, 49 were non-frail, and 39 were frail, with a signifi cant association with functional capacity and quality of life in all groups. The dimensions resulting from physical aspects, pain, and vitality were associated with those that were non-frail. Conclusion: in this study, frailty syndrome was inversely proportional to the quality of life, and signifi cantly associated with functional capacity of older adults. Physical frailty is a manageable condition which can be targeted through geriatric nursing interventions. Descriptors: Aged; Frail Elderly; Quality of Life; Primary Health Care; Geriatric Nursing. RESUMO Objetivo: investigar a associação entre fragilidade física e qualidade de vida de idosos usuários da atenção básica de saúde da capital paranaense. Método: estudo quantitativo transversal realizado com 203 idosos. Os dados foram coletados mediante questionários de nível de atividade física, perda de peso, fadiga/exaustão, qualidade de vida e realização de testes de velocidade da marcha e força de preensão manual. Resultados: dos 203 idosos, 115 eram pré-frágeis, 49 não frágeis, 39 frágeis, havendo em todos os grupos associação signifi cativa para a dimensão capacidade funcional da qualidade de vida. As dimensões limitações por aspectos físicos, dor e vitalidade foram associadas aos não frágeis. Conclusão: no presente estudo, a síndrome da fragilidade se mostrou inversamente proporcional à qualidade de vida e associada signifi cativamente à capacidade funcional dos idosos. Entende-se que a fragilidade física é uma condição gerenciável e pode ser alvejada por meio de intervenções da enfermagem gerontológica. Descritores: Idoso; Idoso Fragilizado; Qualidade de Vida; Atenção Primária à Saúde; Enfermagem Geriátrica. RESUMEN Objetivo: investigar la relación entre fragilidad física y calidad de vida de ancianos usuarios de la atención primaria de salud en la capital del estado. Método: estudio cuantitativo transversal con 203 ancianos. Los datos se recoletaron a través de cuestionarios de actividad física, pérdida de peso, fatiga/agotamiento, calidad de vida y pruebas de velocidad de marcha y fuerza de prensión. Resultados: de los 203 ancianos, 115 eran pre-frágiles, 49 no frágiles, 39 frágiles, con asociación signifi cativa de la dimensión capacidad funcional de la calidad de vida en todos los grupos. Las dimensiones limitaciones por "aspectos físicos", "dolor" y "vitalidad" se asociaron con aquellos no frágiles. Conclusión: en este estudio, el síndrome de fragilidad era inversamente proporcional a la calidad de vida y sign...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Fragilidade e qualidade de vida de idosos usuários da atenção básica de saúde

et al. 2016

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“…Fatigue is a common problem in older adults and has been suggested as being a part of the normal aging process [37]. The higher prevalence of fatigue in PD, however, cannot be explained only by older age.…”

Section: Discussionmentioning

confidence: 99%

Clinical determinants of primary and secondary fatigue in patients with Parkinson’s disease

et al. 2013

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Clinical and psychosocial factors associated separately with primary and secondary fatigue in Parkinson's disease (PD) patients have not been thoroughly studied before. The aim of our study was to assess factors associated with different fatigue domains in groups with primary and secondary fatigue in PD separately. We divided 165 nondemented PD patients according to the absence/presence of depression, anxiety and excessive somnolence into groups with primary fatigue (N = 63) and with secondary fatigue (N = 102). Fatigue domains examined using the multidimensional fatigue inventory were associated through multiple linear regression analyses for each group separately with sociodemographic data, disease duration, functional status as assessed by the Unified Parkinson's Disease Rating Scale, treatment, depression, anxiety, excessive somnolence and sleep quality. Out of the assessed non-motor symptoms, fatigue was the most frequent (77.6 %). The prevalence of fatigue in the secondary fatigue group was significantly higher than in the primary fatigue group. Both fatigue groups differed significantly in factors associated with different fatigue domains. Functional status or other disease-related factors were not associated with primary fatigue. In the secondary fatigue group, we found associations between some fatigue domains and functional status, older age, male gender and higher anxiety scores. To our knowledge, this is the first study to separately describe clinical determinants and psychosocial factors associated with different fatigue domains in primary and secondary fatigue in PD, underlining the importance of distinguishing primary and secondary fatigue in future PD studies and clinical practice.

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“…As most activities of daily living involve submaximal contractions, our observation of lower ME in mobility-impaired older adults has implications for daily energy cost and the experience of symptomatic fatigue in this population. Although it has been suggested that muscle fatigue may be related to symptomatic fatigue in frail older individuals (1), evidence for such a connection is lacking. It is possible that muscle ME may provide a physiological link between muscle and symptomatic fatigue, although further investigation is necessary.…”

Section: Perspectives and Significancementioning

confidence: 99%

Human skeletal muscle metabolic economy in vivo: effects of contraction intensity, age, and mobility impairment

Christie

Tonson

Larsen

et al. 2014

American Journal of Physiology-Regulatory, Integrative and Comp

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Christie AD, Tonson A, Larsen RG, DeBlois JP, Kent JA. Human skeletal muscle metabolic economy in vivo: effects of contraction intensity, age, and mobility impairment. Am J Physiol Regul Integr Comp Physiol 307: R1124 -R1135, 2014. First published August, 27, 2014; doi:10.1152/ajpregu.00083.2014.-We tested the hypothesis that older muscle has greater metabolic economy (ME) in vivo than young, in a manner dependent, in part, on contraction intensity. Twenty young (Y; 24 Ϯ 1 yr, 10 women), 18 older healthy (O; 73 Ϯ 2, 9 women) and 9 older individuals with mild-to-moderate mobility impairment (OI; 74 Ϯ 1, 7 women) received stimulated twitches (2 Hz, 3 min) and performed nonfatiguing voluntary (20, 50, and 100% maximal; 12 s each) isometric dorsiflexion contractions. Torque-time integrals (TTI; Nm·s) were calculated and expressed relative to maximal fat-free muscle cross-sectional area (cm 2 ), and torque variability during voluntary contractions was calculated as the coefficient of variation. Total ATP cost of contraction (mM) was determined from flux through the creatine kinase reaction, nonoxidative glycolysis and oxidative phosphorylation, and used to calculate ME (Nm·s·cm Ϫ2 ·mM ATP Ϫ1 ). While twitch torque relaxation was slower in O and OI compared with Y (P Յ 0.001), twitch TTI, ATP cost, and economy were similar across groups (P Ն 0.15), indicating comparable intrinsic muscle economy during electrically induced isometric contractions in vivo. During voluntary contractions, normalized TTI and total ATP cost did not differ significantly across groups (P Ն 0.20). However, ME was lower in OI than Y or O at 20% and 50% MVC (P Յ 0.02), and torque variability was greater in OI than Y or O at 20% MVC (P Յ 0.05). These results refute the hypothesis of greater muscle ME in old age, and provide support for lower ME in impaired older adults as a potential mechanism or consequence of age-related reductions in functional mobility. bioenergetics; mitochondria; creatine kinase; glycolysis; oxidative phosphorylation WHILE MANY OF THE CHANGES in neuromuscular properties that occur with advanced age, such as declines in strength and contractile velocity (5, 64), can be detrimental to physical function, some age-related physiological changes may act in a compensatory manner and, thereby, help maintain function to some degree. For instance, it has been suggested that a greater proportion of type I muscle fibers (35,55,56), slowed contractile properties (62, 71), and slower motor unit discharge rates, particularly during maximal contractions (8,12,37,38,68), may place older muscle at an economic advantage (41, 49). While age-related differences in muscle metabolic economy (ME; mass-normalized torque produced per unit ATP consumed) have been shown in rat muscle (13, 32), a systematic analysis of muscle ME in aging humans has only recently begun (41,54). Such a focus on muscle ME is critical to informing studies of age-related changes in the energy cost of whole body activities, such as walking, which generally involve measures of...

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Fatigue in older adults: an early indicator of the aging process?

Abstract: ABSTRACT. The aim of this paper is to give an overview (Aging Clin Exp Res 2010; 22: 100-115)

Cited by 186 publications

References 143 publications

Fragilidade e qualidade de vida de idosos usuários da atenção básica de saúde

Fragilidade e qualidade de vida de idosos usuários da atenção básica de saúde

Clinical determinants of primary and secondary fatigue in patients with Parkinson’s disease

Human skeletal muscle metabolic economy in vivo: effects of contraction intensity, age, and mobility impairment

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