Fatigue in out‐patients with inflammatory bowel disease is common and multifactorial

Abstract

SUMMARY BackgroundPatients with inflammatory bowel disease (IBD) often complain of fatigue.

Is Iron Deficiency in the Absence of Anemia Associated With Fatigue in Inflammatory Bowel Disease?

“…This study used a more liberal definition than our study (ferritin <30 ug/L). Anemia was not associated with fatigue and neither was iron deficiency, although the investigators did not distinguish the role of iron deficiency in the absence of anemia (11).…”

“…The General Fatigue subscale is commonly referenced as the primary fatigue descriptor, rather than a total MFI scale score. A cutoff of > 13 for the General Fatigue subscale was used to delineate significant fatigue, as has been done in previous IBD studies based on the 95 th percentile of the score in a healthy control group (9,11,35).…”

“…(2)(3)(4)(5)(6). It is also quite prevalent in inflammatory bowel disease (IBD) (7)(8)(9)(10)(11) and has been shown to adversely affect quality of life (9). In population-based samples of individuals with IBD in Canada (8) and the Netherlands (9), problematic fatigue was reported by over two-thirds of those with active disease [70% (8); 76% (9)], and by 30% (8) and 37% (9) with inactive disease.…”

Utmattelse ved inflammatorisk tarmsykdom

“…I vårt materiale var hemoglobinnivå/anemi assosiert med fatigue i fire av studiene (14,18,21,24), mens det i åtte (9,11,15,17,19,20,26,27) ikke ble påvist noen slik sammenheng.…”

The effect of increasing physical activity and/or omega-3 supplementation on fatigue in inflammatory bowel disease

“…Results from randomised controlled trials (RCTs) on IBD-related fatigue have reported reductions of fatigue with infliximab or adalimumab [6,7,8], and benefits from a stress management programme [9] and solution-focused therapy [10]. However, few studies identify fatigue as their primary endpoint [11], or compare fatigue occurring in the two types of IBD (Crohn's Disease [CD] and Ulcerative Colitis [UC]); in addition, the management of fatigue in remission has received limited attention, despite the fact that focusing specifically on the inactive disease phase allows investigation of IBD-related fatigue unrelated to gut symptoms.…”