Fatigue in patients with sarcoidosis, compared with the general population

Hinz, Andreas; Fleischer, Michael; Brähler, Elmar; Wirtz, Hubert; Bosse-Henck, A.

doi:10.1016/j.genhosppsych.2011.05.009

Cited by 63 publications

(46 citation statements)

References 23 publications

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“…These scores were comparable to previous amputee research [1], which was on average slightly more fatigued than the general population (8.7 ± 4 [18]). The close to normal fatigue levels of our patient population leave little room for improvement and potentially a floor effect for this measure.…”

Section: Discussionsupporting

confidence: 86%

Does a Torsion Adapter Improve Functional Mobility, Pain, and Fatigue in Patients with Transtibial Amputation?

Segal

Kracht

Klute

2014

Clinical Orthopaedics &Amp; Related Research

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Background Turning gait is an integral part of daily ambulation and likely poses a greater challenge for patients with transtibial amputation compared with walking a straight pathway. A torsion adapter is a prosthetic component that can increase transverse plane compliance of the prosthesis and decrease the torque applied to the residual limb, but whether this will improve patients' mobility, pain, and fatigue remains unknown.Questions/purposes Does prescription of a torsion adapter translate to improvements in (1) functional mobility and (2) self-perceived pain and fatigue in moderately active patients with lower limb amputation? Methods Ten unilateral transtibial amputees wore a torsion or rigid adapter in random order. Functional mobility was assessed through a field measurement using an activity monitor and through a laboratory measurement using a 6-minute walk test that included turns. The residual limb pain grade assessed self-perceived pain and the Multidimensional Fatigue Inventory assessed fatigue. Results We found relatively small functional differences for amputees wearing a torsion adapter versus a rigid adapter. Amputees wearing a torsion adapter tended to take more low-and medium-intensity steps per day (331 ± 365 and 437 ± 511 difference in steps; effect size = 0.44 and 0.17; confidence interval [CI], 70-592 and 71-802; p = 0.019 and 0.024, respectively). They also experienced less pain interference with activities (1.9 ± 1.7 change in score; effect size = 0.83; CI, 0.3-3.4; p = 0.026) when wearing a torsion adapter. However, these patients took a similar number of total steps per day, walked a comparable distance in 6 minutes, and reported similar residual limb pain and fatigue. Conclusions For a moderately active group of amputees, the torsion adapter did not translate to substantial improvements in functional mobility and self-perceived pain and fatigue. The small increases in low-and mediumintensity activities with less pain interference when wearing a torsion adapter provides evidence to support prescribing this device for amputees with difficulty navigating the household and community environments. Level of Evidence Level II, therapeutic study. See Instructions for Authors for a complete description of levels of evidence.

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Section: Discussionsupporting

confidence: 86%

Does a Torsion Adapter Improve Functional Mobility, Pain, and Fatigue in Patients with Transtibial Amputation?

Segal

Kracht

Klute

2014

Clinical Orthopaedics &Amp; Related Research

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“…Korenromp et al in the Netherlands examined 75 patients with sarcoidosis, and 76% of them reported fatigue in the course of the disease. Yet, the patients were not examined with the help of www.pneumonologia.viamedica.pl [19].…”

Section: Discussionmentioning

confidence: 99%

Fatigue in Patients with Inactive Sarcoidosis Does Not Correlate with Lung Ventilation Ability or Walking Distance. Pilot Study

Zieleźnik

Jastrzębski

2015

Advances in Respiratory Medicine

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Fatigue in patients with inactive sarcoidosis does not correlate with lung ventilation ability or walking distance. Pilot StudyZmęczenie u chorych z nieaktywną sarkoidozą nie koreluje ze zdolnością wentylacyjną płuc oraz z dystansem chodu. Badanie pilotażoweThe work has been conducted under a grant from the Silesian Medical University: project No. KNW-1-025/D/2/0 Abstract Introduction: Fatigue is one of many symptoms reported by patients with sarcoidosis. It is believed that fatigue may be the cause of exercise intolerance and reduced quality of life in patients with sarcoidosis. The purpose of the work was to present the frequency of fatigue prevalence in patients with sarcoidosis and to investigate the correlation between fatigue and the results of pulmonary function tests and walking distance. Material and methods: A total of 74 patients with sarcoidosis in a stable phase of the disease, not treated in the past with glucocorticoids or immunosuppressive drugs, and without indications for treatment at the time of the study were examined. In all patients fatigue evaluation was carried out with the use of the Fatigue Assessment Scale questionnaire (FAS); dyspnoea was assessed with the use of the Medical Research Council scale (MRC). Body Mass Index (BMI), spirometry, and a 6-minute walk test were additionally performed. The control group included 30 healthy volunteers who completed the FAS. Results: In the examined group of patients fatigue was diagnosed in 36 patients (50%), and in 5 (6.94%) -strong fatigue was observed. The remaining 31 (43.06%) patients felt no fatigue. The average value of points obtained by FAS questionnaire in sarcoidosis patients was significantly higher than the respective value in the control group (p = 0.02). A significantly higher number of points by FAS questionnaire was observed in female patients with sarcoidosis (p = 0.04) in comparison to men. No significant statistical correlation between fatigue index FAS and BMI (r = 0.22, p = 0.11), FEV 1 (r = -0.11, p = 0.3), FEV 1 % pred. (r = 0.01, p = 0.9), FVC (r = −0.03, p = 0.77), FEF 25−75 (r = −0.23, p = 0.1) and the distance in the six-minute walk test (6MWT) (r = −0.01, p = 0.9) was observed. However, there was a weak negative correlation between the age of the patients and the FAS index (r = −0.29, p = 0.01). Conclusions: Fatigue in patients with sarcoidosis does not correlate with the results of lung function tests or with walking distance in 6MWT.

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“…Similarly, hypothyroidism is not very likely in the absence of dry skin. The 81% prevalence of tiredness in hypothyroidism was high compared with its prevalence in a number of other diseases: 36% in Parkinson's disease (31), 71% in chronic obstructive pulmonary disease (32), 78% in adult coeliac disease (33), and 84% in sarcoidosis (34). The exact mechanism leading to tiredness in hypothyroidism is unknown.…”

Section: Symptoms In Hypothyroidismmentioning

confidence: 99%

Hypothyroid symptoms and the likelihood of overt thyroid failure: a population-based case–control study

Carlé¹,

Pedersen²,

Knudsen³

et al. 2014

European Journal of Endocrinology

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Background: It is generally accepted that patients suffering from hypothyroidism may express few symptoms, but this has not been studied in a population-based study design. Objectives: To study the array of symptoms as they are reported in newly diagnosed overt autoimmune hypothyroidism using a population-based case-control design. Methods: Patients with new overt autoimmune hypothyroidism (nZ140) and their individually matched thyroid disease-free controls (nZ560) recruited from the same population underwent a comprehensive program and self-reported a number of symptoms. We identified the symptoms associated with overt hypothyroidism and calculated positive (LRC) and negative (LRK) likelihood ratios as well as diagnostic odds ratios (DORs) as measures for the association between disease state and symptoms. Results: Among 34 symptoms investigated, 13 symptoms were statistically overrepresented in hypothyroidism. Hypothyroid patients suffered mostly from tiredness (81%), dry skin (63%), and shortness of breath (51%). Highest DORs (95% CI) were reported for tiredness (5.94 (3.70-9.60)), hair loss (4.58 (2.80-7.51)), and dry skin (4.09 (2.73-6.16)). A hypothyroidismcomponent-score was defined as the number of hypothyroidism-associated symptoms (range: 0-13). LRC for participants with a hypothyroidism-component-score of 0 was 0.21 (0.09-0.39), meaning that the post-test probability was lowered to 21% of what it was before asking for symptoms. LRC for scores of 1-2/3/4-6/7-9/10-13 were: 0.47 (0.30-0.72)/1.16 (0.70-1.87)/1.90 (1.29-2.45)/3.52 (2.30-5.36)/6.29 (2.30-17.7). Conclusions: None of the individual symptoms of hypothyroidism had high LRs or DORs. Thus, neither the presence nor absence of any individual hypothyroidism symptom was reliable in the decision making of who should have their thyroid function tested. Therefore, even minor suspicion should lead to a blood test.

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Fatigue in patients with sarcoidosis, compared with the general population

Cited by 63 publications

References 23 publications

Does a Torsion Adapter Improve Functional Mobility, Pain, and Fatigue in Patients with Transtibial Amputation?

Does a Torsion Adapter Improve Functional Mobility, Pain, and Fatigue in Patients with Transtibial Amputation?

Fatigue in Patients with Inactive Sarcoidosis Does Not Correlate with Lung Ventilation Ability or Walking Distance. Pilot Study

Hypothyroid symptoms and the likelihood of overt thyroid failure: a population-based case–control study

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