Fatigue in persons who have lived with spinal cord injury for &gt;20 years

Lidal, Ingeborg Beate; Jensen, Andreas Tue Ingemann; Larsen, Tore Wentzel; Stanghelle, Johan Kvalvik

doi:10.1038/sc.2012.110

Cited by 18 publications

(17 citation statements)

References 28 publications

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“…A study observing fall after 100 SCIs [42] found ambulatory SCI persons to fall more often (54 %) than wheelchair-bound SCI persons (36 %). Unpublished data from another study [43] include recording of fractures after SCI in 165 patients with traumatic SCI more than 20 years ago (Ingeborg Lidal, personal communication). In this dataset, 52 % had at least one traumatic fracture after injury, whereas 19 % had a traumatic femur fracture.…”

Section: Discussionmentioning

confidence: 97%

Differences in Bone Mineral Density, Markers of Bone Turnover and Extracellular Matrix and Daily Life Muscular Activity Among Patients with Recent Motor-Incomplete Versus Motor-Complete Spinal Cord Injury

et al. 2014

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Spinal cord injury (SCI) leads to severe bone loss, but the associated mechanisms are poorly described in incomplete SCI individuals. The purpose of the study is to compare alterations in bone mineral density (BMD) and serum biomarkers of bone turnover in recent motor-incomplete to -complete SCI men, as well as to describe their physical activity and spasticity. We studied 31 men with acute SCI. Whole-body DXA scans, serum biomarkers and self-reported activity and spasticity were examined 1 and/or 3 and 12 months after the injury. We observed a decrease in proximal femur BMD (p < 0.02) in both the groups. Serum phosphate and carboxy-terminal-collagen crosslinks were significantly lower in motor-incomplete versus complete SCI men, whereas albumin-corrected Ca(2+) (p = 0.02) were lower only 3 months after injury. When data from all 31 SCI participants were pooled, we observed increased serum matrix metalloproteinase-2 (MMP-2) and tissue inhibitors of MMP-2 (TIMP-2) (p < 0.02) whereas TIMP-1 decreased (p = 0.03). BMD correlated positively with self-reported activity (r = 0.59, p = 0.04) and negatively with spasticity (r = 0.74, p = 0.02) 12 months after injury. As a summary, men with motor-incomplete SCI developed significant proximal femur bone loss 12 months after injury and exhibited increased bone resorption throughout the first year after the injury. Compared with complete SCI men, incomplete SCI men show attenuated bone resorption. Our pooled data show increased turnover of extracellular matrix after injury and that increased exercise before and after injury correlated with reduced bone loss.

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Section: Discussionmentioning

confidence: 97%

Differences in Bone Mineral Density, Markers of Bone Turnover and Extracellular Matrix and Daily Life Muscular Activity Among Patients with Recent Motor-Incomplete Versus Motor-Complete Spinal Cord Injury

et al. 2014

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“…The prevalence of fatigue in individuals with longterm SCI is approximately 25 percent, and fatigue can result in higher depression and lower self-efficacy [16][17]. Systematic reviews have indicated that negative affect is significantly associated with lower quality of life (QoL) and higher posttraumatic stress [18].…”

Section: Introductionmentioning

confidence: 99%

Comparison of mental health between individuals with spinal cord injury and able-bodied controls in Neiva, Colombia

et al. 2014

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Abstract-Although research has investigated the mental health of individuals with spinal cord injury (SCI), an overwhelming majority of this research has been conducted in the United States, Western Europe, and other developed countries. The purpose of this study was to compare the mental health of individuals with SCI with able-bodied controls in Neiva, Colombia, South America. Subjects included 40 Colombians with SCI and 42 age-and sex-matched controls (N = 82). The groups did not differ based on age, sex, years of education, or socioeconomic status. However, controls were twice as likely to be married. Four measures assessed mental health, including satisfaction with life (Satisfaction with Life Scale), depressive symptoms (Patient Health Questionnaire-9), self-esteem (Rosenberg Self-Esteem Scale), and anxiety (State-Trait Anxiety Inventory). In comparison with ablebodied controls, individuals with SCI reported significantly lower mental health on both depressive symptoms and satisfaction with life. These effect sizes were medium and large, respectively. The groups did not differ significantly on measures of self-esteem or anxiety. Mental health of individuals with SCI should be considered a central part of SCI rehabilitation interventions, particularly in Latin America.

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“…Disabling fatigue and use of support of other people for ambulation were found to increase the odds of having depression in this group. Lidal et al 34 reported that prevalence of fatigue was 25% among patients who had lived with SCI for more than 20 years. Same study reported direct correlation between high depression scores with high fatigue scores, which is in agreement with our study.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of depression, fatigue, and sleep disturbances in patients with myelopathy: Their relation with functional and neurological recovery

Menon

Gupta

Khanna

et al. 2016

The Journal of Spinal Cord Medicine

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Objectives: To observe the prevalence of fatigue, depression, and sleep disturbance in patients with myelopathy and their correlation with neurological and functional recovery. Patients and methods: Study conducted in a university tertiary research hospital with 127 patients with myelopathy (92 males) admitted to neurorehabilitation unit between January 2010 and December 2013. Mean age was 32.71 ± 13.08 years (range 15-65 years), and mean duration of injury was 76.22 ± 82.5 days (range 14-365 days). Functional status and impairments were assessed using Barthel Index and Spinal Cord Independence Measures. Depression, fatigue, and sleep disturbances were assessed using Hospital Anxiety and Depression Scale, Fatigue Severity Scale, and Pittsburgh Sleep Quality Index scales, respectively. Neurological recovery was assessed using American Spinal Injury Association's impairment scale. Results: Forty-four out of 104 (42%) patients had borderline or confirmed depression, 36/108 (33%) had significant fatigue, and 62/106 (58%) had significant sleep disturbances at admission. Significant correlation was observed between change in fatigue and depression scores with change in functional status scores (P < 0.05) but no correlation (P > 0.05) between change in sleep disturbance scores and functional status score and neurological recovery (P > 0.05). Similarly, change in fatigue and depression scores had no correlation with neurological status improvement. Fatigue, depression, and sleep disturbance scores showed significant improvement, that is, admission vs. discharge scores (P < 0.05) with significant correlation between improvement in all three variables (P < 0.05). Conclusions: Study variables showed significant improvement in the present study with myelopathy patients but not necessarily correlating with functional and neurological recovery.

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Fatigue in persons who have lived with spinal cord injury for >20 years

Cited by 18 publications

References 28 publications

Differences in Bone Mineral Density, Markers of Bone Turnover and Extracellular Matrix and Daily Life Muscular Activity Among Patients with Recent Motor-Incomplete Versus Motor-Complete Spinal Cord Injury

Differences in Bone Mineral Density, Markers of Bone Turnover and Extracellular Matrix and Daily Life Muscular Activity Among Patients with Recent Motor-Incomplete Versus Motor-Complete Spinal Cord Injury

Comparison of mental health between individuals with spinal cord injury and able-bodied controls in Neiva, Colombia

Prevalence of depression, fatigue, and sleep disturbances in patients with myelopathy: Their relation with functional and neurological recovery

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