Fatigue in psoriasis: a controlled study

Skoie, Inger Marie; Dalen, Ingvild; Ternowitz, Thomas; Jonsson, Grete; Kvivik, Ingeborg; Norheim, Katrine Brække; Omdal, Roald

doi:10.1111/bjd.15375

Cited by 47 publications

(57 citation statements)

References 40 publications

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“…As discussed in two reviews of fatigue and psoriasis, fatigue cannot be objectively quantified and thus, all fatigue instruments depend on patient self‐reporting . Importantly, in the current study, the degree of fatigue did not correlate with the severity of psoriasis, but was associated with increased pain and depression . It is difficult to separate the symptoms of depression and pain from fatigue .…”

contrasting

confidence: 54%

“…The greater level of fatigue in those with PsA was statistically significant. In this study, as in the current study by Skoie et al ., in patients with psoriasis alone, the degree of fatigue did not correlate with the severity of cutaneous disease . When studying fatigue, it is important to remember that fatigue may be a sign of other comorbidities that are more frequent in patients with psoriasis (for instance, obstructive sleep apnoea and other sleep disorders and cardiovascular diseases).…”

supporting

confidence: 53%

“…Fatigue is a common complaint of patients with chronic diseases including psoriatic disease, and can have a major impact on their quality of life. The current study by Skoie et al ., in this issue of the BJD , addresses the fatigue experienced by patients with psoriasis without arthritis, in the week just prior to assessment . None of these patients had psoriatic arthritis (PsA).…”

mentioning

confidence: 99%

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Fatigue and psoriasis

Rosen

2017

Br J Dermatol

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contrasting

confidence: 54%

supporting

confidence: 53%

mentioning

confidence: 99%

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Fatigue and psoriasis

Rosen

2017

Br J Dermatol

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“…Historical controls ( n = 84) were selected from a study performed by Skoie et al . that examined fatigue in patients with psoriasis and consisted of healthy acquaintances of patients with psoriasis from Stavanger University Hospital in Norway . These patients were Norwegian speaking and age 18 years or older; exclusion criteria in that study included a diagnosis of psoriasis, prior history of cancer, chronic inflammatory diseases or untreated hyper‐ or hypothyroidism.…”

Section: Methodsmentioning

confidence: 99%

“…Fatigue severity was assessed with the vitality subscale, and general mental health was assessed with the mental health subscale using patients’ scores recorded from their first visit . Clinically significant fatigue was defined as a score ≤ 35 . This cut‐off point was used by Dagfinrud et al .…”

Section: Methodsmentioning

confidence: 99%

Fatigue in systemic lupus erythematosus and other autoimmune skin diseases

et al. 2019

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Summary Background Fatigue is a well‐established symptom in systemic lupus erythematosus (SLE), but has not been well characterized in other skin‐limited autoimmune diseases such as cutaneous lupus erythematosus (CLE), amyopathic dermatomyositis (ADM) or autoimmune blistering diseases (AIBD). Objectives In this retrospective study, we compared fatigue in controls (n = 84) with that in patients enrolled in prospective longitudinal databases with SLE (n = 165), CLE (n = 226), ADM (n = 136) and AIBD (n = 79). Methods We used the 36‐Item Short Form Survey (SF‐36) vitality scale to analyse median scores and the percentages of patients with clinically significant fatigue (defined as a score ≤ 35) between experimental groups and controls. Results Median and interquartile range (IQR) vitality scores demonstrated greater fatigue in the experimental groups (SLE 35, IQR 20–55; CLE 50, IQR 30–70; ADM 50, IQR 30–65; AIBD 55, IQR 35–70) than in controls (73, IQR 65–85) (P < 0·05 for each experimental group vs. control). The SLE group had worse fatigue than all of the other groups (P < 0·05 SLE vs. each group), but there was no difference between the CLE, ADM or AIBD groups (all P > 0·05). In addition, the experimental groups had more clinically significant fatigue (score ≤ 35) (SLE 44·2%, CLE 25·2%, ADM 31·6%, AIBD 24·1%) than controls (2%) (P < 0·01 for each experimental group vs. control). The SLE group had more clinically significant fatigue than the CLE group (P < 0·01); however, there was no difference in clinically significant fatigue between SLE and either ADM (P = 0·17) or AIBD (P = 0·055). Conclusions These findings demonstrate that patients with skin‐limited autoimmune disease experience more fatigue than controls. Fatigue is an important symptom that negatively affects quality of life for patients. It should be addressed by clinicians and measured in future clinical trials.

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Physical and Psychosocial Burden of Psoriatic Arthritis: Longitudinal Data From a Population‐Based Study in Norway

Haugeberg

Nilsen

Kavanaugh

et al. 2020

Arthritis Care & Research

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Objective. Psoriatic arthritis (PsA) can have a significant impact on health-related quality of life (HRQoL). Data on the timing of changes in the HRQoL of patients with PsA are limited. The present study was undertaken to explore associations between sleep disturbance, fatigue, pain, anxiety, depression, general health status, and satisfaction with life before and after a diagnosis of PsA compared to the general population. Methods. Patients diagnosed with PsA between the Nord-Trøndelag Health Study (HUNT2 [1995-1997] and HUNT3 [2006-2008]) surveys were compared to the general population. The adjusted odds ratio (OR adj) with 95% confidence interval (95% CI) was estimated at both time points. Results. Among 36,507 individuals participating in both the HUNT2 and HUNT3 surveys, 160 were diagnosed with PsA between the surveys. The prevalence of sleep disturbances and fatigue was higher in PsA patients after diagnosis compared to the general population (OR adj 2.24 [95% CI 1.55-3.25] and OR adj 1.94 [95% CI 1.27-2.98], respectively). The prevalence of pain and poor health status were higher in patients with PsA compared with the general population even before PsA was diagnosed (OR adj 2.81 [95% CI 1.96-4.02] and OR adj 3.08 [95% CI 2.19-4.35], respectively) and increased after diagnosis of PsA (OR adj 12.87 [95% CI 6.27-26.40] and OR adj 5.63 [95% CI 3.99-7.95], respectively). For anxiety, depression, and life satisfaction, patients who developed PsA were comparable to the general population both before and after the diagnosis of PsA. Conclusion. Compared to the general population, PsA patients reported a higher prevalence of pain and poorer health status before diagnosis. Increased prevalence of sleep disturbances and fatigue in PsA patients was only found after the PsA diagnosis, and no differences between patients with PsA and the control group were found for anxiety and depression.

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Fatigue in psoriasis: a controlled study

Abstract: Nearly 50% of patients with psoriasis suffered from substantial fatigue. Fatigue severity was associated with smoking, pain and depression, but not with psoriasis severity.

Cited by 47 publications

References 40 publications

Fatigue and psoriasis

Fatigue and psoriasis

Fatigue in systemic lupus erythematosus and other autoimmune skin diseases

Physical and Psychosocial Burden of Psoriatic Arthritis: Longitudinal Data From a Population‐Based Study in Norway

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