2021
DOI: 10.3390/jcm10163566
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Fatigue in Systemic Lupus Erythematosus and Rheumatoid Arthritis: A Comparison of Mechanisms, Measures and Management

Abstract: Fatigue is a common constitutional feature of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). While the two diseases share a common mechanism of autoimmunity, they differ in their clinical manifestations and treatment. Fatigue is one of the most commonly reported symptoms in both groups, associated with pain, depression and anxiety, and affecting function, work and quality of life. Fatigue is not easy to assess or conceptualise. It can be linked to disease activity, although it is not always,… Show more

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Cited by 27 publications
(13 citation statements)
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“…Anxiety, depression, and fatigue often co-exist as manifestations of each other (27,28). Previous studies have shown that fatigue is strongly associated with anxiety and depression in SLE and RA patients (29)(30)(31). Increasing evidence of the role of inflammation in mental illness and the link between autoimmune diseases and mental illness is helping to expand the field of immunopsychiatry and have an impact on patient treatment and outcomes.…”
Section: Discussionmentioning
confidence: 99%
“…Anxiety, depression, and fatigue often co-exist as manifestations of each other (27,28). Previous studies have shown that fatigue is strongly associated with anxiety and depression in SLE and RA patients (29)(30)(31). Increasing evidence of the role of inflammation in mental illness and the link between autoimmune diseases and mental illness is helping to expand the field of immunopsychiatry and have an impact on patient treatment and outcomes.…”
Section: Discussionmentioning
confidence: 99%
“…Fatigue is a major complaint in patients with SLE and has been linked to SLE disease activity [ 74 ], as well as cognitive impairment in NPSLE [ 75 ]. A study by Hopia et al [ 76 ] comprising 28 patients with NPSLE from a Swedish clinical setting showed a positive correlation (ρ = 0.43; p < 0.05) between CSF levels of a proliferation-inducing ligand (APRIL) and fatigue measured with the Fatigue Severity Scale (FSS) [ 77 ].…”
Section: Methodsmentioning
confidence: 99%
“…Patients with RA and SLE are known to suffer from fatigue and depressed mood [264,265]. However, there is no clear correlation between disease activity and subjective feelings of fatigue [266]. Fatigue is also a common symptom of OA [267].…”
Section: Neuropsychiatric Phenomena In the Context Of Chronic Periphe...mentioning
confidence: 99%