Fatigue is associated with high circulating leptin levels in chronic hepatitis C

Piche, Thierry; Gelsi, Ève; Schneider, S.; Hébuterne, Xavier; Giudicelli, J.; Ferruà, Bernard; Laffont, C.; Benzaken, Sylvia; Hastier, P; Montoya, María Luisa Pedro-Botet; Longo, Fabrice; Rampal, Patrick; Tran, Albert

doi:10.1136/gut.51.3.434

Cited by 67 publications

(67 citation statements)

References 39 publications

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“…6). In our opinion, in CHC patients muscle pain and fatigue can be explained by some typical endocrine and/or immune alterations: a reduction both of estrogen levels and estrogen receptors with an increase of oxidative damage; a decrease of the intrahepatic production of IGF-I which plays a crucial role in the homeostasis of skeletal muscle; a hyperstimulation of the immune system where the high circulating leptin levels in chronic hepatitis C seem to reflect the high levels of TNF-alpha, one of the most important inducers ofleptin secretion (31)(32)(33).…”

Section: Resultsmentioning

confidence: 99%

An Italian Study on Health-Related Quality of Life and Fatigue in Patients with Chronic Fatigue Syndrome and Patients with Chronic HCV Virus Infection: Similarities and Differences

Racciatti

Gorgoretti

Sepede

et al. 2011

Int J Immunopathol Pharmacol

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Severe fatigue and a significantly reduced health-related quality of life (HRQoL) have been described in patients with chronic fatigue syndrome (CFS) in comparison with patients affected by chronic hepatitis C (CHC) and other chronic medical conditions. We examined 39 CFS and 49 CHC patients to explore whether fatigue and a poor HRQoL represent a greater medical and social problem in CFS than in CHe. The severity of fatigue and the HRQoL were assessed using the Fatigue Impact Scale (FIS) and the Health Status Questionnaire Short Form-36 (SF-36), respectively. The statistical analysis showed both a higher score offatigue and a lower HRQoL in CFS than in CHC patients. Furthermore, in CUC patients the FIS evaluation showed a significantly reduced score of the psychosocial domain in comparison with the other domains. Multivariate linear regression analysis revealed female gender as the most important positive variable in chronic hepatitis C patients for total score of FIS. In conclusion, CFS was associated with a severe and disabling fatigue and an impaired HRQOL. In particular, both fatigue and all aspects of HRQOL perceived by CFS patients were significantly impaired compared to CHC patients. Consequently, management of fatigue should be considered a priority in order to improve HRQOL in CFS patients. In CHC patients the impact of fatigue on HRQoL was less significant than in CFS patients, even though the FIS evaluation showed a significant impairment of the psychosocial domain.

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Section: Resultsmentioning

confidence: 99%

An Italian Study on Health-Related Quality of Life and Fatigue in Patients with Chronic Fatigue Syndrome and Patients with Chronic HCV Virus Infection: Similarities and Differences

Racciatti

Gorgoretti

Sepede

et al. 2011

Int J Immunopathol Pharmacol

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“…Women with HCV report greater fatigue than men [11,35]. The course of fatigue has not been well studied, but one study showed that fatigue tends to increase in the first 3 months of antiviral therapy, returning to baseline levels after 6 months [36].…”

Section: Epidemiologymentioning

confidence: 96%

“…Compared with healthy controls and patients with chronic diseases not affecting the liver, HCV patients indicate fatigue interferes more with physical activity and mental concentration, and they experience less relief from fatigue after rest and sleep [37]. However, severity of fatigue has not been shown to differ significantly between HCV patients and patients with other chronic liver diseases, such as alcoholic liver disease [37] and primary biliary cirrhosis [35].…”

Section: Epidemiologymentioning

confidence: 98%

Depression and fatigue: Challenging comorbidities in HCV-infected patients

Hilsabeck

Webb²,

Stern³

2007

Curr hepatitis rep

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Depression and fatigue are two of the most common problems reported by patients with hepatitis C virus (HCV). Psychosocial and biological factors contribute to the etiology of these symptoms, but the exact pathogenesis of each is not well understood. Depression is managed effectively in most HCV patients using antidepressant medication, but management strategies for fatigue are lacking. Additional research is needed to refine the definition of fatigue and its measurement, as well as to identify the causes of these disabling symptoms, how they relate to other neuropsychiatric symptoms, and which interventions are most effective.

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“…In another study, high serum leptin levels were found in patients with chronic HCV infection (24). However, further studies are needed to clarify this issue.…”

Section: Resistinmentioning

confidence: 97%

Relationship between the frequency of hepatitis B virus infections and levels of serum adipokines in patients with hepatosteatosis and insulin resistance

Balkan¹,

Gülşen²,

Balkan³

et al. 2017

Eur J Ther

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Objective:Although the steatogenic effect of hepatitis B virus (HBV) has been established in several studies, it is not yet known whether it leads to hepatosteatosis in anti-HBc IgG-positive patients. This study aimed to investigate the relationship between the frequency of HBV and levels of serum adipokines in patients with hepatosteatosis and insulin resistance. Methods: Eighty patients diagnosed with hepatosteatosis by ultrasonography, who were admitted to our polyclinic between July 2011 and June 2012 for various reasons, and who had insulin resistance were included. Homeostasis model assessment-insulin resistance of >2.7 was considered as insulin resistance, and these patients was investigated for anti-HBc IgG. The anti-HBc IgG level was analyzed by enzyme-linked immunosorbent assay. Levels of adiponectin, resistin, and leptin in serum samples were analyzed in anti-HBc IgG (+) and anti-HBc IgG (−) groups. Results: Anti-HBc IgG was positive in 29 (36.2%) patients and negative in 51 (63.8%). While the level of leptin in the anti-HBc IgG (+) group was 31569.72±14027.64 ng/mL, it was 25410.73±10978.26 ng/mL in the anti-HBc IgG (−) group. The levels of leptin in the anti-HBc IgG (+) and anti-HBc IgG (−) groups were statistically significant (p=0.047). However, levels of adiponectin and resistin were not different between the groups. Conclusion: These results suggest that anti-HBc IgG positivity is involved in the etiology of hepatosteatosis and insulin resistance as well.

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Fatigue is associated with high circulating leptin levels in chronic hepatitis C

Cited by 67 publications

References 39 publications

An Italian Study on Health-Related Quality of Life and Fatigue in Patients with Chronic Fatigue Syndrome and Patients with Chronic HCV Virus Infection: Similarities and Differences

An Italian Study on Health-Related Quality of Life and Fatigue in Patients with Chronic Fatigue Syndrome and Patients with Chronic HCV Virus Infection: Similarities and Differences

Depression and fatigue: Challenging comorbidities in HCV-infected patients

Relationship between the frequency of hepatitis B virus infections and levels of serum adipokines in patients with hepatosteatosis and insulin resistance

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