To scrupulously predict the creep-fatigue life of materials, a creep life prediction model is firstly proposed in this study considering real-time creep damage derived from the Kachanov creep damage model; secondly, combined with the Chaboche fatigue damage model and the nonlinear coupling mechanism of continuous damage mechanics, a creep-fatigue life prediction model of material is ulteriorly presented in this paper; finally, the effectiveness of the creep-fatigue life model is corroborated by experiment data of DZ125, whose prediction results are in the ±2.0 dispersion zone and then the creep-fatigue life of the turbine blade is calculated to compare with the experimental results of the blade specimen to further prove the practicability, whose error is about 3.2%, which can provide a theoretical reference for the damage prediction, durability analysis, and life prediction of the turbine blade.