This paper presents the results of the study on thin walled steel portal frames, which are used in Japan as basic structural frames for motorway viaducts. A serious problem found in many such frames is fatigue cracks developed at the beam to column connection. To act as a measure against the fatigue failure, in some cases a hole is provided at the beam -column connection of the frames. In this study, dynamic analysis using real earthquake data from 3 different earthquakes have been carried out to examine the influence of such a hole on the global behavior of the frame and also on the local buckling around the location of the hole.Non-linear, large displacement analysis was performed using the FEM program MSC.Marc. The hole radius has been varied and used as a parameter of study. The results showed significant effect of the hole on local buckling and global behavior, specifically when the radius of the hole was larger than 100 mm.