Fatigue, quality of life and health status in sarcoidosis

Vries, Jolanda De

doi:10.1183/1025448x.00032007

Cited by 21 publications

(21 citation statements)

References 45 publications

(61 reference statements)

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“…The majority of patients with sarcoidosis have impaired QoL and health status due to the burden of the disease, leading to limitations in activities of daily living, social isolation, and depression [10,[13][14][15]. In line with others, Salligan demonstrated in a small study that sarcoidosis patients were more fatigued, more depressed, more dyspneic, and less physically active, and had lower physical performance than their ageand race-matched controls [70].…”

Section: Quality Of Lifesupporting

confidence: 49%

“…A growing body of evidence has demonstrated the impact of not only organ-specific symptoms but also nonspecific problems, including lack of energy, fatigue, pain, anxiety, depression, and cognitive symptoms, on patients' lives, inducing significant worsening of (health-related) quality of life (HR QoL) [10,[12][13][14]. Multifactorial influences include systemic inflammation, decreased pulmonary function, sleeping disorders, small fiber neuropathy (SFN), sarcoid myopathy, hypoxia or glucocorticoid use, and deconditioning [15][16][17][18]. This can lead to physical inactivity, loss of fitness and muscle strength, and thus increased fatigue [19,20].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Physical activity and training in sarcoidosis: review and experience-based recommendations

Strookappe

Saketkoo

Elfferich

et al. 2016

Expert Review of Respiratory Medicine

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Section: Quality Of Lifesupporting

confidence: 49%

Section: Introductionmentioning

confidence: 99%

Physical activity and training in sarcoidosis: review and experience-based recommendations

Strookappe

Saketkoo

Elfferich

et al. 2016

Expert Review of Respiratory Medicine

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“…As Samuel Butler stated: »Life is one long process of getting tired« (51). The occurence of fati gue in sarcoidosis is well known, but the exact incidence has not been established and varies from 30 to 70% depending on the age, sex, race of patients and organ invol vement in the granulomatous process (52). The sensation of fatigue in sarcoidosis has been studied for years.…”

Section: Vitamin D and Neuropsychological Functions In Patients With mentioning

confidence: 99%

The role of vitamin D in multisystem sarcoidosis / Uloga vitamina D u sarkoidozi

Mihailović-Vučinić¹,

Ignjatović²,

Dudvarski-Ilić³

et al. 2012

Journal of Medical Biochemistry

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Summary: Recently published data indicate that vitamin D abnormalities are common in sarcoidosis patients. The purpose of this study was to compare serum vitamin 25(OH)D levels among sarcoidosis patients with different clinical courses of the disease. The study also included the first observations on cognitive functions (i.e. depression and fatigue syndrome) in relation to vitamin D deficiency in sarcoidosis patients. At the Biochemical Laboratory of the Clinical Center of Serbia, Belgrade, vitamin D25(OH)D was measured using the Elecsys ® Vitamin D total test. A total of 226 patients with biopsy-positive sarcoidosis were analyzed. The average median value of serum vitamin D was 9.47 mg/L, suggesting severe deficiency. Statistically significant correlation was found in patients with chronic disease and low levels of serum vitamin 25(OH)D (Chi-Square=6.044; df=2; p=0.014). The patient group with vitamin D serum levels higher than 20 mg/L showed higher levels of the mean forced vi tal capacity (FVC) by 380 mL, and forced expiratory volume in one second (FEV1) by 220 mL, when compared to the patient group with lower serum vitamin D. A statistically significant role was established for serum vitamin 25(OH)D levels as the predictor of fatigue (R 2 =0.878; p=0.038 (b=0.216)) and depression in patients with sarcoidosis (R 2 =0.80; p=0.000 (b=0.391)). The insufficiency of 25(OH)D seems to be an important factor in predicting the course of chronic disease, significant lung function impairments and cognitive failures such as fatigue and depression. The fact that the majo rity of the analyzed sarcoidosis patients had totally deficient serum 25(OH)D levels made this finding even more notable. Keywords: vitamin D, deficiency, sarcoidosisKratak sadr`aj: Nedavno objavljena istra`ivanja kod obole lih od sarkoidoze govore o ~estim abnormalnim vrednostima vitamina D. Cilj ove studije bio je da se uporedi nivo vita mina 25(OH)D kod obolelih od sarkoidoze sa razli~itim klini~kim tokom bolesti. Tako|e, ova studija predstavlja prva za pa `anja o vezi izme|u kognitivnih funkcija (odnosno ose}a ja depresije i zamora) i deficita vitamina D kod obolelih od sarko idoze. U Biohemijskoj laboratoriji Klini~kog centra Srbije vitamin D -25(OH)D meren je kori{}enjem testa Elec sys ® Vitamin D. Analizirano je 226 bolesnika sa sarkoidozom potvr|enom biopsijom. Prose~na srednja vrednost vitamina D u serumu bila je 9,47 mg/L, {to ukazuje na ozbiljan nedostatak. Statisti~ki zna~ajna korelacija na |e na je kod pa cije nata sa hroni~nom formom bolesti i niskim nivoom vitamina 25(OH)D u serumu (Xi-kvad rat=6,044; df=2; p=0,014). Grupa pacijenata sa nivoom vitamina D u serumu ve}im od 20 mg/L pokazuje ve}i nivo srednjeg for siranog vitalnog kapaciteta (FVC) za 380 mL i forsiranog ekspi ratornog volumena u prvoj sekundi (FEV1) za 220 mL u od nosu na grupu pacijenata sa ni`im nivoom D vitamina. Utvr|eno je da nivo vitamina 25(OH)D u serumu ima stati sti~ki zna~ajnu ulogu kao prediktor zamora i depresije kod obolelih od sarkoidoze. Insuficijencija 25(OH)D ...

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“…[1][2][3]8 Inspiratory muscle training has been shown to improve depression in previous studies. 36,39 Although depression was alleviated in both groups, a higher inspiratory muscle training work load was not superior to the lower work load in the present study.…”

Section: Fatigue and Depressionmentioning

confidence: 99%

“…7 Fatigue and dyspnea are some of the most prevalent symptoms in sarcoidosis; 30 -90% of subjects report severe fatigue perception. 3,8 Although resting dyspnea is not generally prevalent, exercise-induced dyspnea is especially perceived in stage II-IV of sarcoidosis and correlates with reduced respiratory muscle strength. 4,5 Indeed, all of these symptoms affect patients' quality of life.…”

Section: Introductionmentioning

confidence: 99%

Effects of Inspiratory Muscle Training in Subjects With Sarcoidosis: A Randomized Controlled Clinical Trial

Karadalli¹,

Boşnak-Güçlü²,

Camcıoğlu³

et al. 2015

Respir Care

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BACKGROUND: Respiratory muscle weakness occurs in sarcoidosis and is related to decreased exercise capacity, greater fatigue, dyspnea, and lower quality of life in sarcoidosis patients. The effects of inspiratory muscle training in this population have not been comprehensively investigated so far. This study was planned to investigate the effects of inspiratory muscle training on exercise capacity, respiratory and peripheral muscle strength, pulmonary function and diffusing capacity, fatigue, dyspnea, depression, and quality of life in subjects with sarcoidosis. METHODS: This was a prospective, randomized, controlled, and double blind study. Fifteen sarcoidosis subjects (treatment group) received inspiratory muscle training at 40% of maximal inspiratory pressure (P Imax ), and 15 subjects (control group) received sham therapy (5% of P Imax ) for 6 weeks. Functional and maximal exercise capacity, respiratory and peripheral muscle strength, pulmonary function and diffusing capacity, fatigue, dyspnea, depression, and quality of life were evaluated. RESULTS: Functional (P < .001) and maximal exercise capacity (P ‫؍‬ .038), respiratory muscle strength (P Imax [P < .001] and P Emax [P ‫؍‬ .001]), severe fatigue (P ‫؍‬ .002), and dyspnea perception (P ‫؍‬ .02) were statistically significantly improved in the treatment group compared with controls; no significant improvements were observed in pulmonary function and diffusing capacity, peripheral muscle strength, fatigue, depression, and quality of life between groups after inspiratory muscle training. CONCLUSIONS: Inspiratory muscle training improves functional and maximal exercise capacity and respiratory muscle strength and decreases severe fatigue and dyspnea perception in subjects with early stages of sarcoidosis. Inspiratory muscle training can be safely and effectively included in rehabilitation programs. (ClinicalTrials.gov registration NCT02270333.)

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Fatigue, quality of life and health status in sarcoidosis

Cited by 21 publications

References 45 publications

Physical activity and training in sarcoidosis: review and experience-based recommendations

Physical activity and training in sarcoidosis: review and experience-based recommendations

The role of vitamin D in multisystem sarcoidosis / Uloga vitamina D u sarkoidozi

Effects of Inspiratory Muscle Training in Subjects With Sarcoidosis: A Randomized Controlled Clinical Trial

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