Fatigue-related diurnal variations of cognitive performance in multiple sclerosis and stroke patients

Claros-Salinas, Dolores; Bratzke, Daniel; Greitemann, Georg; Nickisch, Nancy; Ochs, Lisa G.; Schröter, Hannes

doi:10.1016/j.jns.2010.04.018

Cited by 61 publications

(57 citation statements)

References 17 publications

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“…Practice increased the response speed over time (test period in total 3.5 hr) for the controls, while this was not the case for those suffering from fatigue after a TBI (Ashman et al., 2008). Furthermore, a diurnal decline in cognitive function was reported for multiple sclerosis and stroke patients suffering from fatigue compared with controls (Claros‐Salinas et al., 2010). …”

Section: Introductionmentioning

confidence: 99%

Mental fatigue and impaired cognitive function after an acquired brain injury

et al. 2018

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ObjectiveMental fatigue is a common subjective symptom following an acquired brain injury. In many cases, this is long‐lasting with a considerable negative impact on work, studies, social activities, and quality of life. No objective test for mental fatigue exists today. The aim of this study was to investigate whether mental fatigue can be objectively measured.Materials and MethodsThis study included 32 controls with no mental fatigue and 42 well‐rehabilitated participants who suffered from long‐term mental fatigue following stroke, traumatic brain injury, encephalitis or meningitis, and late effects after brain tumor. Attention, processing speed and working memory were assessed using a test and retest design following a demanding reading exercise.ResultsSignificant interactions were found for tests measuring processing speed, working memory, and attention. The control group improved at the second test, while those who suffered from mental fatigue did not.ConclusionsThis study indicates impaired cognitive performance over time after cognitive activity for individuals suffering from mental fatigue after an acquired brain injury.

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Section: Introductionmentioning

confidence: 99%

Mental fatigue and impaired cognitive function after an acquired brain injury

et al. 2018

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“…Cognitive fatigability has been measured by alertness measurements or increasing reaction time in the course of the day [9] or after a standardized cognitive load [10]. Motor fatigability may be easier to diagnose than cognitive fatigability.…”

Section: Introductionmentioning

confidence: 99%

Fatigability Assessment Using the Fatigue Index Kliniken Schmieder (FKS) Is Not Compromised by Depression

Dettmers¹,

Riegger²,

Müller³

et al. 2016

Health

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Background: Attractor-based kinematic gait analysis using the Fatigue Index Kliniken Schmieder (FKS), have been suggested as a sensitive tool to determine motor fatigability in persons with Multiple Sclerosis (pwMS). Hypothesis: Depression does not affect the FKS to a similar degree as in pwMS. Methods: We recruited 32 patients with major depression. Data were collected with two accelerometers attached to both ankles. Data were recorded for one minute at the beginning and at the end of the treadmill test. Attractor attributes were used to analyze the data. Results: The mean Fatigue Index Kliniken Schmieder (FKS) was 2.1. The change of the attractor (δM) was 3.7 and the change of variability (δD) was 0.6. Mean values were clearly below values of pwMS with fatigability from a previous publication. However, the individual level values from six individuals-five of them showed pain related comorbidity besides depression-fell within the lower pathological range. There was no correlation between Hamilton depression scale and the attractor attributes (δM and δD). Discussion: Depression does not affect gait as motor fatigability does in pwMS.Results from subjects with pain during the treadmill test show a moderately increased variability and moderately altered attractors.

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“…Another factor complicating measurement is the variation in cognition and fatigue across the day. A diurnal decline in cognitive performance was observed in stroke patients (but not controls), corresponding to the patients' subjective reports of increasing cognitive fatigue during the day [ 87 ]. There is also the impact of communication diffi culties and fatigue, with cortical stroke patients often conscious of mental fatigue while speaking.…”

Section: Cognitive Impairmentmentioning

confidence: 93%

Post-Stroke Fatigue: Common but Poorly Understood

Cumming

Mead

2015

Management of Post-Stroke Complications

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Fatigue is experienced by the majority of stroke survivors and often persists even after other symptoms of stroke have resolved. Post-stroke fatigue has important negative effects on a person's quality of life and their social connectedness. The research literature on post-stroke fatigue is still in its infancy, and our understanding of why it develops is based more on potential associates than defi nitive causal explanations. The factors most strongly associated with fatigue after stroke include physical disability and depression, but there are many other potential contributors. Fatigue is multi-dimensional, and any explanatory model must include a wide range of contributing factors, many of which have bi-directional associations with fatigue. Several interventions aimed at reducing post-stroke fatigue have been trialled in small-scale studies, with only limited success. There is great scope for improvements in treatment. Many factors that are relevant to fatigue are modifi able (e.g., sleep quality, physical activity levels), and there are lessons to be learned from approaches used in other models of fatigue (e.g., multiple sclerosis, cancer). Before we can hope to identify effective interventions, however, we need a more detailed understanding of not only why fatigue occurs after stroke, but also why it persists.

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Fatigue-related diurnal variations of cognitive performance in multiple sclerosis and stroke patients

Cited by 61 publications

References 17 publications

Mental fatigue and impaired cognitive function after an acquired brain injury

Mental fatigue and impaired cognitive function after an acquired brain injury

Fatigability Assessment Using the Fatigue Index Kliniken Schmieder (FKS) Is Not Compromised by Depression

Post-Stroke Fatigue: Common but Poorly Understood

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