Fatigue syndrome due to localized radiation

Greenberg, Donna; Sawicka, Joanna; Eisenthal, Sherman; Ross, Douglas S.

doi:10.1016/0885-3924(92)90106-r

Cited by 154 publications

(80 citation statements)

References 10 publications

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“…The data, from all 110 patients, on core symptoms confirm previous observations (Smets, 1993; Lamszus et al, 1994; Greenberg et al (1992) have described a pattern of an initial decrease, followed by an increase, in tiredness during radiotherapy. We were unable to confirm this observation: our data show a steady increase during treatment, with the major impact being during the final week of treatment.…”

Section: Discussionsupporting

confidence: 88%

A quantitative approach to the distress caused by symptoms in patients treated with radical radiotherapy

Munro

Potter²

1996

Br J Cancer

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Summary A computerised self-assessment instrument was used to capture data on the distress caused by symptoms in 110 patients treated with radical radiotherapy. Patients selected symptoms from a list of 34 problems and then quantified the distress associated with each problem using a linear Analogue self assessment (LASA)-type scale. The test instrument was feasible: 90% of assessments were completed in under 14 min. There was a significant increase in tiredness and significant decrease in anxiety and worries about the family, during treatment. Menopausal symptoms and post-surgical problems were important causes of distress in the patients with breast cancer. When the area under the curve method was used to quantify distress in the patients with breast cancer, difficulty concentrating, pain and sleep disturbances emerged as significantly troublesome problems. Computerised self-assessment may have a useful role in quantifying the distress caused by treatment with radiotherapy.

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Section: Discussionsupporting

confidence: 88%

A quantitative approach to the distress caused by symptoms in patients treated with radical radiotherapy

Munro

Potter²

1996

Br J Cancer

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“…In line with Smets et al [26] and Greenberg et al [13], just after radiation therapy, fatigue was increased but returned quickly to baseline level. This also explains why receiving adjuvant therapy did not predict fatigue 6 months after surgical treatment.…”

Section: Discussionsupporting

confidence: 82%

“…It might be that fatigue, like subjective well-being [14], is only temporarily affected by a major life event, such as being diagnosed with and treated for cancer. Another possible explanation is the response-shift phenomenon: patients get used to increased levels of fatigue and reset their internal standards [13,27].…”

Section: Discussionmentioning

confidence: 99%

Personality and fatigue in patients with benign or malignant breast disease

Michielsen

Steeg

Roukema

et al. 2007

Support Care Cancer

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Goals of work The aim of the study was to examine the role of five general personality traits in fatigue in a group of patients with breast cancer (BC) and a group with benign breast problems (BBP). Materials and methods Of the 304 participating women, 127 patients had BC and 177 BBP. A fatigue scale was completed before diagnosis and 1, 3, and 6 months after diagnosis (benign patients) or surgical treatment (BC patients). A personality questionnaire (NEO-FFI) and a depression scale (CES-D) were completed before diagnosis. Main results The BC group was less tired before diagnosis, more tired 1 month after diagnosis, and equally tired 3 and 6 months after diagnosis. In the total group, women were more tired over time when they were more neurotic, less agreeable, or more introverted. After controlling for depressive symptoms, demographics, and medical factors, baseline depressive symptoms (β=0.29, p<0.05), neuroticism (β=0.29, p<0.05), and extraversion (β=−0.25, p< 0.05) predicted fatigue 6 months later. After also including baseline fatigue, only neuroticism (β=0.22, p<0.05) and baseline fatigue (β=0.79, p<0.001) predicted fatigue.Conclusions Personality is more strongly related to fatigue than demographics, the diagnosis cancer, receiving cancer treatment, and baseline depressive symptoms and fatigue. When replicated, screening and treating women who are at risk to experience high levels of fatigue is recommended.

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“…[14]). Fatigue appears to be one of these acute side effects, reaching its peak during or just after radiotherapy and then declining [8,9,25]. Indeed, this course was found on the most sensitive scale of the MFI, the General Fatigue scale.…”

Section: Discussionmentioning

confidence: 99%

Fatigue, depression and quality of life in cancer patients: how are they related?

Visser¹,

Smets²

1998

Support Care Cancer

316

203

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In a study concerning a group of cancer patients undergoing radiotherapy three research questions were addressed. (1) Is fatigue a valid criterion for depression in these somatically ill patients? (2) What is the 'cause-andeffect' relation between fatigue and depression? (3) To what extent are fatigue and depression related to patients' quality of life. A heterogeneous sample of cancer patients (n p 250) were interviewed before treatment, 2 weeks after treatment and 9 months later. Fatigue was measured using the MFI, a self-report instrument covering five dimensions of fatigue. Depression was assessed with the non-somatic items of the CES-D. Quality of life had to be indicated on a Cantrill ladder. Fatigue and depression do not follow the same course over time. Just after radiotherapy, fatigue had either increased or remained stable, depending on the dimension under consideration. Depression, in contrast, decreased. Nine months later fatigue had decreased, whereas levels of depression remained stable. Concurrent relations between fatigue and depression were mostly moderate. There was no strong evidence for a cause-and-effect relationship between depression and fatigue. Depression showed highest concurrent relationships with quality of life, especially before treatment. Prospectively, depression and the dimension of physical fatigue were the main predictors for quality of life. Fatigue is not a valid criterion for depression in these patients. Nor is there a strong cause-and-effect relationship. Both depression and physical fatigue are relevant to patients' quality of life.

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Fatigue syndrome due to localized radiation

Cited by 154 publications

References 10 publications

A quantitative approach to the distress caused by symptoms in patients treated with radical radiotherapy

A quantitative approach to the distress caused by symptoms in patients treated with radical radiotherapy

Personality and fatigue in patients with benign or malignant breast disease

Fatigue, depression and quality of life in cancer patients: how are they related?

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