Throughout history, people have observed aerial events that appeared extraordinary and anomalous. In earlier eras, these were often interpreted through a lens that invoked special classes of divine beings, such as angels (who, compared with gods, are regarded as more likely to interact with humans). Today, in our ostensibly secular scientific age, there is a tendency to assume such observers were mistaken, and that with the benefit of modern knowledge, these events can be “debunked” and attributed to conventional naturalistic explanations. However, recent years have seen a burgeoning interest and even concern over the issue of unidentified aerial phenomena. Through the lens of our “space age,” these are sometimes interpreted using notions such as extraterrestrial agents. Ultimately though, this article suggests that both categories of explanation, from angels to aliens, may be the perennial human quest to render comprehensible, through the prism of prevailing beliefs and traditions, an ongoing encounter with celestial phenomena that remain genuinely unknown but deeply significant.