Fatores de mau prognóstico nas peças operatórias de pacientes submetidos ao tratamento cirúrgico do câncer colorretal

Volpato, Marília Granzotto; Koch, Kaiser de Souza

doi:10.1590/s0101-98802008000400003

Cited by 5 publications

(11 citation statements)

References 29 publications

(96 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When the groups were stratified by age, we found that patients older than 50 years were significantly more affected by CRC (P = 0.0001), confirming that age is a risk factor for the development of CRC, as demonstrated in several previous studies (Farhoud et al, 2002;Volpato and Koch, 2008;Park et al, 2011).…”

Section: Clinical Featuressupporting

confidence: 85%

“…Mucinous tumors are defined by the presence of extracellular mucin at more than 50% of the tumor volume and account for approximately 8-20% of all CRCs (Volpato and Koch, 2008;Rocha et al, 2010). The presence of signet ring cells is a variant of mucinous tumors and is found in 0.1-2.4% of CRCs.…”

Section: Introductionmentioning

confidence: 99%

“…The presence of signet ring cells is a variant of mucinous tumors and is found in 0.1-2.4% of CRCs. The presence of mucus in CRCs has been associated with more advanced stages of the disease and indicates a locally aggressive tumor with a poor prognosis (Volpato and Koch, 2008) compared to the non-mucinous type (Farhoud et al, 2002;Henrique-Filho et al, 2004). Life expectancy is less than 5 years in patients with mucinous CRC (Rocha et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Matrix metalloproteinase 9 -1562C/T polymorphism increased protein levels in patients with colorectal cancer in a sample from southeastern Brazil

et al. 2016

View full text Add to dashboard Cite

ABSTRACT. We examined whether the allelic and/or genotypic profile of locus -1562C/T of the matrix metalloproteinase (MMP-9) gene influences the protein expression levels of MMP-9 in patients with colorectal cancer (CRC) compared with controls. A total of 104 patients with CRC and 84 controls were evaluated. Peripheral blood was collected from both groups and DNA extraction was performed for -1562C/T genotyping; the plasma was used for MMP-9 quantification. The CT genotype was associated with increased MMP-9 expression (P = 0.0211). High levels of protein, independently of polymorphisms, were observed in the patient group (P < 0.0001) compared to controls. Mucinous tumors with signet ring cells were more frequent in females (P = 0.0177). Overall, patients older than 50 years showed a significant risk of developing CRC (P = 0.0001). MMP- 9 plasma expression was increased in patients with CRC compared to controls, particularly in those with the heterozygous -1562CT genotype.

show abstract

Section: Clinical Featuressupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Matrix metalloproteinase 9 -1562C/T polymorphism increased protein levels in patients with colorectal cancer in a sample from southeastern Brazil

et al. 2016

View full text Add to dashboard Cite

show abstract

“…A recent study showed that an increase in the composition of the tumor stroma and a reduction in epithelial cellularity were significantly correlated with genetic signatures related to epithelial-mensenchymal transition (12). The depth of invasion through the intestinal wall and the presence of lymph node metastases, which are recognized as the most important independent prognostic factors in CRC, related to survival and risk of recurrence, in addition to indicating the therapeutic approach (22,43,44), were significantly related to the percentage of stroma. All pT1 patients were stroma-low, while 75.6% of the pT2 patients were stroma-low.…”

Section: Discussionmentioning

confidence: 99%

Stromal scoring in advanced colon and rectal cancer: Stroma-rich tumors and their association with aggressive phenotypes

et al. 2022

View full text Add to dashboard Cite

Background: Our aim was to explore relevance of the proportion between neoplastic cell component and tumor-associated stroma in order to assess its association with confirmed aggressive phenotypes of right/left colon and rectum cancers in a large series of patients. Methods: The quantification of stroma component was performed in patients diagnosed with colorectal adenocarcinoma who underwent surgical resection. The analyzed variables were age, gender, anatomical/pathological features, and tumor-stroma proportion. Tumor-stroma proportion was estimated based on slides used in routine pathology for determination of T status and was described as low, with a stromal percentage ?50% or high, with a stromal percentage >50%. The tumor-stroma proportion was estimated by two observers, and the inter-observer agreement was assessed. Results: The sample included 390 colorectal adenocarcinoma patients. Stroma-rich tumors were observed in 53.3% of cases. Well-differentiated tumors had the lowest stromal proportions (p = 0.028). Stroma-poor tumors showed less depth of invasion (p<0.001). High stromal content was observed in association with tumor budding, perineural, angiolymphatic, and lymph node involvement, and distant metastasis (p?0.001). Colorectal adenocarcinoma without lymph node or distant metastasis involvement had lower stromal proportion, while metastatic ones exhibited high stromal content (p <0.001). The inter-rater reliability (concordance) between the estimations of pathologists for tumor-stroma proportions was high (?=0.746). Conclusion: The tumorstroma proportion in colorectal adenocarcinoma was associated with adverse prognostic factors, reflecting the stage of the disease. Stroma-rich tumors showed a significant correlation with advancement of the disease and its aggressiveness. Due to its availability tumor-stroma proportion evaluation has high application potential and can complement current staging system for colorectal adenocarcinoma.

show abstract

“…2,5,14,15 The established prognostic factors include depth of tumor invasion of the intestinal wall and presence of nodal metastases (most relevant), presence of venous or lymphatic invasion, and the degree of tumor differentiation. [16][17][18] Anatomopathological staging of the surgical specimen represents the main tool to be used in isolation to infer the prognosis and survival of patients with CRC, representing the independent dominant variable that most affects survival. 18 It is also considered the most important prognostic factor, guiding the choice of the ideal cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

Diagnosis of Advanced Disease in Cases of Colorectal Cancer in a Developing Country

Silva

Collaço

Cunha

et al. 2021

Journal of Coloproctology

View full text Add to dashboard Cite

Objectives Colorectal cancer (CRC) is the second leading cause of cancer death in the world, with survival correlated with the extension of the disease at diagnosis. In many low-/middle-income countries, the incidence of CRC is increasing rapidly, while decreasing rates are observed in high-income countries. We evaluated the anatomopathological profile of 390 patients diagnosed with CRC who underwent surgical resection, over a six-year period, in the state of Paraíba, northeastern Brazil. Results Adenocarcinomas accounted for 98% of the cases of primary colorectal tumors, and 53.8% occurred in female patients. The average age of the sample was 63.5 years, with 81.8% of individuals older than 50 years of age and 6.4% under 40 years of age. The most frequent location was the distal colon; pT3 status was found in 71% of patients, and pT4 status, in 14.4%. Angiolymphatic and lymph-node involvements were found in 48.7% and 46.9% of the cases respectively. Distant metastasis was observed in 9.2% of the patients. Advanced disease was diagnosed in almost half of the patients (48.1%). The women in the sample had poorly-differentiated adenocarcinomas (p = 0.043). Patients under 60 years of age had a higher rate of lymph-node metastasis (p = 0.044). Tumor budding was present in 27.2% of the cases, and it was associated with the female gender, the mucinous histological type, and the depth of invasion (pT3 and pT4). Conclusions We conclude that the diagnosis of advanced disease in CRC is still a reality, with a high occurrence of aggressive prognostic factors, which results in a worse prognosis.

show abstract

Fatores de mau prognóstico nas peças operatórias de pacientes submetidos ao tratamento cirúrgico do câncer colorretal

Abstract: Descritores: Câncer colorretal, prognóstico, linfonodos, estadiamento do câncer, histopatologia.

Cited by 5 publications

References 29 publications

Matrix metalloproteinase 9 -1562C/T polymorphism increased protein levels in patients with colorectal cancer in a sample from southeastern Brazil

Matrix metalloproteinase 9 -1562C/T polymorphism increased protein levels in patients with colorectal cancer in a sample from southeastern Brazil

Stromal scoring in advanced colon and rectal cancer: Stroma-rich tumors and their association with aggressive phenotypes

Diagnosis of Advanced Disease in Cases of Colorectal Cancer in a Developing Country

Contact Info

Product

Resources

About