Fatores de risco associados à colonização por Candida spp em neonatos internados em uma Unidade de Terapia Intensiva Neonatal brasileira

Borges, R.M.; Soares, Leandro; Brito, Cristiane Silveira de; Brito, Denise Von Dolinger de; Abdallah, Vânia Olivetti Steffen; Filho, Paulo Pinto Gontijo

doi:10.1590/s0037-86822009000400014

Cited by 15 publications

(14 citation statements)

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“…C. albicans was the commonest species (67.1%) isolated from both oral and rectal sites of infants, whereas other non-albicans Candida species accounted for one third of isolates (Table 2). It is difficult to correlate the results of this study with most other studies which have been investigated mainly the relationship between risk factors of Candida colonization and developing of Candida infections in neonates hospitalized in NICU [1,3-5,9]. However, a study in Greece has found that Candida species colonization was detected in 12.1% of neonates during a 12-month period, and C. albicans was isolated from 42% of colonized neonates.…”

Section: Resultsmentioning

confidence: 66%

“…In addition, candidemias were diagnosed more in colonized neonates (6.9%) as compared with 0.76% of noncolonized neonates (P = 0.002)[3]. A recent study from Brazil reported that 19% of the neonates were colonized by Candida species which were divided equally between C. albicans (50%) and non- albicans Candida (50%) [1]. The increased colonization of non- albicans Candida species as well as their cause of candidaemia in neonates and adult Jordanian patients has been shown to be similar to other studies from various countries [1,2,6,4,7,23].…”

Section: Resultsmentioning

confidence: 99%

“…Candida colonization of infants is a risk factor for developing candidiasis, especially in neonatal intensive care unit (NICU) [1-4]. During the past decade colonization and candidaemia with non-albicans Candida species has risen dramatically with high rates of carriage in hospitalized infants including neonates admitted to NICU [2,5,6].…”

Section: Introductionmentioning

confidence: 99%

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Epidemiological characteristics of Candida species colonizing oral and rectal sites of Jordanian infants

et al. 2011

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BackgroundThere is evidence that Candida colonization contributes to increasing invasion of candidiasis in hospitalized neonates. Few studies investigated the epidemiology and risk factors of Candida colonization among hospitalized and non-hospitalized infants. This prospective study investigated the major epidemiological characteristics of Candida species colonizing oral and rectal sites of Jordanian infants.MethodsInfants aged one year or less who were examined at the pediatrics outpatient clinic or hospitalized at the Jordan University Hospital, Amman, Jordan, were included in this study. Culture swabs were collected from oral and rectal sites and inoculated on Sabouraud dextrose agar. All Candida isolates were confirmed by the Remel RapID yeast plus system, and further investigated for specific virulence factors and antifungal susceptibility MIC using E-test. Genotyping of C. albicans isolates was determined using random amplified polymorphic DNA (RAPD) analysis method.ResultsA total of 61/492 (12.4%) infants were colonized with Candida species by either their oral/rectal sites or both. Rectal colonization was significantly more detected than oral colonization (64.6% verses 35.4%), particularly among hospitalized infants aged more than one month. The pattern and rates of colonization were as follows: C. albicans was the commonest species isolated from both sites and accounted for 67.1% of all isolates, followed by C.kefyr (11.4%), each C. tropicalis and C. glabrata (8.9%) and C. parapsilosis (3.8%).A various rates of Candida isolates proved to secrete putative virulence factors in vitro; asparatyl proteinase, phospholipase and hemolysin. C. albicans were associated significantly (P < 0.05) with these enzymes than other Candida species. All Candida isolates were susceptible to amphotericin B and caspofungin, whereas 97% of Candida species isolates were susceptible to fluconazole using E-test.The genetic similarity of 53 C. albicans isolates as demonstrated by dendrogram revealed the presence of 29 genotypes, and of these one genotype accounted for 22% of the isolates.ConclusionThis study presents important epidemiological features of Candida colonization of Jordanian infants.

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Section: Resultsmentioning

confidence: 66%

Section: Resultsmentioning

confidence: 99%

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Epidemiological characteristics of Candida species colonizing oral and rectal sites of Jordanian infants

et al. 2011

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“…currently represent a serious matter for the public health, since the rates of incidence and mortality associated with these infections have revealed a considerable increase in third-level hospitals during the last decades [17][18][19] . Species of the genus Candida have been the most frequently isolated agents, which correspond to approximately 80% of the hospital-acquired fungal infections that cause death to 12% to 60% of the patients who develop candidemia [19][20][21] . The occurrence of nosocomial infections by invasive candidiasis at the Universitary Hospital of the Jundiaí Medical College during the period covered by this research was of 4% above the average described by national and international references, which report an occurrence rate of 1.49 to 6.6 cases in 1,000 hospital admissions [22][23][24][25][26] .…”

Section: Ethical Considerationsmentioning

confidence: 99%

Candida spp. isolated from inpatients, the environment, and health practitioners in the pediatric unit at the Universitary Hospital of the Jundiaí Medical College, state of São Paulo, Brazil

Storti

Pasquale

Scomparim

et al. 2012

Rev. Soc. Bras. Med. Trop.

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INTRODUCTION: This study aimed to isolate and identify Candida spp. from the environment, health practitioners, and patients with the presumptive diagnosis of candidiasis in the Pediatric Unit at the Universitary Hospital of the Jundiaí Medical College, to verify the production of enzymes regarded as virulence factors, and to determine how susceptible the isolated samples from patients with candidiasis are to antifungal agents. METHODS: Between March and November of 2008 a total of 283 samples were taken randomly from the environment and from the hands of health staff, and samples of all the suspected cases of Candida spp. hospital-acquired infection were collected and selected by the Infection Control Committee. The material was processed and the yeast genus Candida was isolated and identified by physiological, microscopic, and macroscopic attributes. RESULTS: The incidence of Candida spp. in the environment and employees was 19.2%. The most frequent species were C. parapsilosis and C. tropicalis among the workers, C. guilliermondii and C. tropicalis in the air, C. lusitanae on the contact surfaces, and C. tropicalis and C. guilliermondii in the climate control equipment. The college hospital had 320 admissions, of which 13 (4%) presented Candida spp. infections; three of them died, two being victims of a C. tropicalis infection and the remaining one of C. albicans. All the Candida spp. in the isolates evidenced sensitivity to amphotericin B, nystatin, and fluconazole. CONCLUSIONS: The increase in the rate of hospital-acquired infections caused by Candida spp. indicates the need to take larger measures regarding recurrent control of the environment.

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“…14 The second most common cause of bloodstream infection in pediatric and neonatal patients admitted to intensive care units in the USA, Europe, and Latin America is fungal infections, especially by Candida spp. [13][14][15][16] In recent years, an increase in infections caused by other species of Candida non-albicans, such as Candida tropicalis, Candida glabrata, Candida krusei, Candida lusitaniae and Candida guilliermondii, has been noted. Multicenter studies conducted in Brazil have also confirmed the prevalence of species of Candida albicans and non-albicans (C. tropicalis and parapsilosis).…”

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Thyroid abnormalities in term infants with fungal sepsis

Silva¹,

Araújo²,

Diniz

et al. 2016

Rev. Assoc. Med. Bras.

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Objective: To describe thyroid alterations in term newborns (TNB) with fungal sepsis during NICU hospitalization. Method: The study included six TNB that during the clinical and laboratory manifestations of sepsis with positive cultures for fungus showed changes in thyroid hormones, called low T3 syndrome and low T3-T4 syndrome. TNB that could present hormonal changes caused by disease as those born to mothers with thyroid disease, or who had perinatal asphyxia and major surgeries were excluded. Results: Of six TNB with fungal sepsis, five had positive culture for Candida albicans and one had positive culture for Candida tropicalis. Low T3 syndrome was observed in two TNB (50%), while T3-T4 syndrome was observed in other two (100%). The four children progressed to septic shock. Conclusion: Fungal sepsis is becoming more common among newborns admitted to NICU. Thyroid insufficiency could be a marker of disease severity with possible need for hormone supplementation.

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Fatores de risco associados à colonização por Candida spp em neonatos internados em uma Unidade de Terapia Intensiva Neonatal brasileira

Cited by 15 publications

References 14 publications

Epidemiological characteristics of Candida species colonizing oral and rectal sites of Jordanian infants

Epidemiological characteristics of Candida species colonizing oral and rectal sites of Jordanian infants

Candida spp. isolated from inpatients, the environment, and health practitioners in the pediatric unit at the Universitary Hospital of the Jundiaí Medical College, state of São Paulo, Brazil

Thyroid abnormalities in term infants with fungal sepsis

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