Fatores Interferentes na Interpretação de Dosagens Laboratoriais no Diagnóstico de Hiper e Hipotireoidismo

Graf, Hans; Carvalho, Gisah Amaral de

doi:10.1590/s0004-27302002000100008

Cited by 6 publications

(6 citation statements)

References 148 publications

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“…In this study, as stated before, the higher serum concentration of T 3 on the day of parturition (1.77 ng/ml) when compared to the periods of lactation could be related to the glucocorticoid concentrations, which increase at the end of gestation (Chopra et al, 1975;Mathur et al, 1980). The glucocorticoids stimulate the hepatic and renal deiodination of T 4 and T 3 , which increases the serum concentration of T 3 and may decrease the concentration of T 4 (Thomas et al, 1978;Graf and Carvalho, 2002). However, a decrease in the concentration of T 4 was not observed in this study, in which their values of 42.43 ng/ml immediately after parturition and 34.66 ng/ ml at 30 days of lactation were greater than the concentrations observed at 60 and 90 days of lactation (26.81 and 27.50 ng/ml, respectively).…”

Section: Discussionsupporting

confidence: 66%

Concentrações séricas dos hormônios tireoidianos em ovelhas crioula lanada serrana na gestação e lactação.

Colodel

Martins

et al. 2008

ARCH ZOOTEC

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Os efeitos da gestação e lactação sobre a dinâmica dos hormônios tireoidianos triiodotironina (T3) e tiroxina (T4) foram avaliados em ovelhas Crioula Lanada Serrana na região do Planalto Serrano Catarinense. Para avaliar os efeitos da gestação, foram utilizadas vinte e quatro ovelhas distribuídas aleatoriamente em dois grupos. O grupo I foi formado por 12 ovelhas gestantes e o grupo controle por 12 ovelhas não gestantes (grupo II). Os efeitos da lactação foram avaliados nas mesmas ovelhas do grupo I após a parição (LE) e no grupo controle (NL). Foram colhidas amostras sanguíneas no primeiro, segundo e terceiro terço da gestação, ao parto e aos 30, 60 e 90 dias de lactação. As concentrações de T3 e T4 foram determinadas por radioimunoensaio (RIA). As ovelhas gestantes apresentaram concen-trações séricas de T3 e T4 inferiores àquelas não gestantes. Ao parto não houve diferença significativa nas concentrações de T3 entre os grupos I e II (p>0,05). Durante a lactação as concentrações de T3 foram menores (p£0,05) para LE que para NL. No momento do parto, as concentrações de T3 foram maiores (p£0.05) do que aquelas observadas no período de lactação e as concentrações de T4 em LE, não diferiram de NL. Durante a lactação as concentrações de T4 de LE foram menores (p£0,05) do que em NL. Os resultados deste estudo demonstraram que a gestação causa variação nas concentrações séricas de T3 e T4 que, no momento do parto são similares àquelas observadas em ovelhas não gestantes. A lactação causa diminuição nas concentrações de T3 e T4 em ovelhas Crioula Lanada Serrana.

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Section: Discussionsupporting

confidence: 66%

Concentrações séricas dos hormônios tireoidianos em ovelhas crioula lanada serrana na gestação e lactação.

Colodel

Martins

et al. 2008

ARCH ZOOTEC

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“…Furosemide binds strongly to tireoglobulin and produces a discreet dislocation of T4, increasing free T4 fraction (27,32). In low concentrations, 3 µmol/L, it does not show any effect on the hormones, but in high doses, of 30 µmol/L, it increases free T4 (33,34).…”

Section: Discussionmentioning

confidence: 99%

“…This blockage may be due to the inhibition of the expression of the gene for the b subunit of TSH that leads to the inhibition of the amplitude of nocturnal TSH peaks (27,28). The inhibition of dopaminergic receptors, however, does not stimulate TSH (27,28).…”

Section: Discussionmentioning

confidence: 99%

Nonthyroidal illnesses syndrome in full-term newborns with sepsis

Silva

Araújo

Diniz

et al. 2015

Arch. Endocrinol. Metab.

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Objective: To assess hormonal changes in nonthyroidal illness syndrome (NTIS) in full-term newborns (NT) with sepsis. Materials and methods: We included 28 NT with sepsis divided into 2 groups according to the time of normalization of serum and clinical indicators of infection: group A(A), 16 NT with improvement in up to 8 days; and group B(B), 12 NT improvement after 8 days. Among the 28 NT, 15 NT progressed to septic shock, with 5 NT group A and 10 NT in group B. NT were excluded when they showed severe sepsis and asphyxia, and congenital malformations, as well as those whose mothers had thyroid disease and IUGR. Results: 17 NT (60.7%) presented NTIS. Low T3 was observed in NTIS in 10 NT (58.8%), and low T4 and T3 in 5 NT (29.5%), all of them with septic shock. Two NT showed mixed changes (11.7%). After sepsis was cured, there was no hormonal change, except in 3 NT. Administration of dopamine, furosemide, and corticosteroids did not affect the results. Conclusions: This study indicates that nonthyroidal illness syndrome may be transiently present during sepsis in full-term newborns, especially in cases of prolonged sepsis. Low T3 can occur without changes in reverse T3 (different from adults), and low T4 and T3 occur mainly in patients with septic shock. Arch Endocrinol Metab. 2015;59(6):528-34

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“…Cortisol stimulates hepatic and renal deiodination from T 4 to T 3 by type 1 deiodinase. In addition, the cortisol wave at pre-parturition and at parturition increases the circulating T 3 concentration and may reduce the T 4 serum concentration (Graf and Carvalho, 2002). However, a decrease in the T 4 concentration was not observed in the present study, and its value at parturition (42.43 ng/ml) did not differ from the values observed at the three points of time during gestation (38.74; 38.67; 37.92 ng/ml for the first, second, and last third respectively).…”

Section: Discussionmentioning

confidence: 99%

“…The glucocorticoids stimulate the hepatic and renal deiodination of T 4 and T 3 , which increases the serum concentration of T 3 and may decrease the concentration of T 4 (Thomas et al, 1978;Graf and Carvalho, 2002). However, a decrease in the concentration of T 4 was not observed in this study, in which their values of 42.43 ng/ml immediately after parturition and 34.66 ng/ ml at 30 days of lactation were greater than the concentrations observed at 60 and 90 days of lactation (26.81 and 27.50 ng/ml, respectively).…”

Section: Discussionmentioning

confidence: 99%

Serum concentration of thyroid hormones in crioula lanada serrana ewes in gestation and lactation

Colodel

Martins

et al. 2010

Arch. zootec.

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SUMMARYThe effects of gestation and lactation on the dynamics of the thyroid hormones, triiodothyronine (T 3 ) and thyroxine (T 4 ) were evaluated in Crioula Lanada Serrana ewes from the plateau region in Santa Catarina -Brazil. To evaluate the effects of gestation, twenty four ewes were randomly divided into groups I and II. Group I was composed of 12 pregnant ewes and the control group (II) was composed of 12 non-pregnant ewes. The effects of lactation were evaluated in the same ewes of group I after parturition (LE) and in the control group (NL). Blood samples were taken in the first, second and third periods of gestation, at parturition, and at 30, 60 and 90 days of lactation. T 3 and T 4 concentrations were determined by radioimmunoassay (RIA). Pregnant ewes showed lower serum concentrations of T 3 and T 4 than those of non-pregnant ewes. At parturition, there was no significant difference in T 3 concentrations between groups I and II (p>0.05). During lactation, serum T 3 concentrations were lower (p≤0.05) in LE than in NL ewes. Serum T 3 concentrations were greater (p≤0.05) at lambing than during the lactation periods. Serum T 4 concentrations in LE at parturition did not differ (p>0.05) from those of NL ewes. During lactation, T 4 concentrations of LE were lower (p≤0.05) than those of the NL ewes. The results of this study have shown that gestation causes a variation in the T 3 and T 4 serum concentrations, and that lactation results in a decrease of serum concentrations of T 3 and T 4 in Crioula Lanada Serrana ewes. RESUMOOs efeitos da gestação e lactação sobre a dinâmica dos hormônios tireoidianos triiodotironina (T 3 ) e tiroxina (T 4 ) foram avaliados em ovelhas Crioula Lanada Serrana na região do Planalto Serrano Catarinense. Para avaliar os efeitos da gestação, foram utilizadas vinte e quatro ovelhas distribuídas aleatoriamente em dois grupos. O grupo I foi formado por 12 ovelhas gestantes e o grupo controle por 12 ovelhas não gestantes (grupo II). Os efeitos da lactação foram avaliados nas mesmas ovelhas do grupo I após a parição (LE) e no grupo controle (NL). Foram colhidas amostras sanguíneas no primeiro, segundo e terceiro terço da gestação, ao parto e aos 30, 60 e 90 dias de lactação. As concentrações de T 3 e T 4 foram determinadas por radioimunoensaio (RIA). As ovelhas gestantes apresentaram concentrações séricas de T 3 e T 4 inferiores àquelas não gestantes. Ao parto não houve diferença significativa nas concentrações de T 3 entre os grupos I e II (p>0,05). Durante a lactação as concentrações Archivos de zootecnia vol. 59, núm. 228, p. 510

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Fatores Interferentes na Interpretação de Dosagens Laboratoriais no Diagnóstico de Hiper e Hipotireoidismo

Cited by 6 publications

References 148 publications

Concentrações séricas dos hormônios tireoidianos em ovelhas crioula lanada serrana na gestação e lactação.

Concentrações séricas dos hormônios tireoidianos em ovelhas crioula lanada serrana na gestação e lactação.

Nonthyroidal illnesses syndrome in full-term newborns with sepsis

Serum concentration of thyroid hormones in crioula lanada serrana ewes in gestation and lactation

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