Fats and Sterols

Rodríguez‐Estrada, Maria Teresa; Tatay, Antonio Cilla; Cardenia, Vladimiro; García‐Llatas, Guadalupe

doi:10.1016/b978-0-12-801238-3.00228-2

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…The eicosanoid Lyso-PG (20:5) was higher in IF animals and positively related to cerotic acid levels in vaginal swabs. The fatty acid associated with Lyso-PG (20:5) is a PUFA that is converted to prostaglandins (50). Infertile gilts also had a higher abundance of certain phosphatidylcholines, namely PC(40:6), PC(40:7), PCo(40:6), and PC(40:8), which are highly unsaturated and compatible with IF animals having a buildup of eicosanoids in vaginal tissue at weaning.…”

Section: Discussionmentioning

confidence: 90%

Biomarkers predictive of long-term fertility found in vaginal lipidome of gilts at weaning

Mills

Ferreira

Stevens³

et al. 2021

Journal of Animal Science

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A marker indicative of fertility potential of replacement gilts early in development would decrease culling rates in the sow herd, improve sow herd reproductive efficiency, and reduce production costs. The objective of this study was to determine if vaginal lipid profiles at 21 d postnatal (PN) could predict sow reproductive performance. Vaginal swabs of the anterior vagina were taken at 21 ± 4 d PN from gilts born on a commercial sow production facility for lipidomic analysis. Animals were followed prospectively for two years and assigned to reproductive performance categories based on observation of estrus or piglets weaned per sow per year (PSY) across two farrowings. Lipids were extracted from cellular material collected with swabs taken from high fertility (HF; n=28; ≥26 PSY) and infertile (IF; n=34; no estrus, no pregnancy) animals and multiple reaction monitoring (MRM)-profiling was used for lipidome analysis. Relative abundance of arachidonic acid (ARA, C20:4) and docosahexaenoic acid (DHA, C22:6) were lower (P<0.05) in IF gilts than HF gilts, whereas abundance of the free fatty acids cerotic (C26:0), ximenic (C26:1), and nonadecanoic (C19:0) acids were greater (P<0.05) in IF gilts. Additionally, eicosapentaenoic acid (C20:5) a precursor of prostaglandins was higher (P<0.05) in IF gilts. The perspective of having a panel of lipids captured with vaginal swabs at weaning that can predict reproductive efficiency of gilts shows promise and warrants future research in this area.

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Section: Discussionmentioning

confidence: 90%

Biomarkers predictive of long-term fertility found in vaginal lipidome of gilts at weaning

Mills

Ferreira

Stevens³

et al. 2021

Journal of Animal Science

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“…Biomembranes exhibit a discerning preference for incorporating specific fatty acids, particularly favoring long and very long polyunsaturated fatty acids that contribute to the formation of fluidic membranes. A study by Rodriguez-Estrada et al [460] has associated long-chain lipid metabolites derived from LA and ALA with the preservation of membrane properties. Sensor proteins typically monitor and regulate the physicochemical properties of membranes [7,461,462].…”

Section: Influence Of Fatty Acids On Bilayer Propertiesmentioning

confidence: 99%

“…They have the potential to influence the recruitment, activation, and function of immune cells. However, it is essential to recognize that eicosanoids can exhibit both pro-inflammatory and anti-inflammatory effects, with the ultimate effect determined by various factors, including mediator concentrations, timing of production, and the sensitivity of targeted cells/tissues [460,659]. Commonly, eicosanoids derived from different fatty acids, such as AA, Mead acid, and EPA, exhibit strikingly distinct biological effects, despite their closely resembling molecular structures.…”

Section: Eicosanoidsmentioning

confidence: 99%

Review of Eukaryote Cellular Membrane Lipid Composition, with Special Attention to the Fatty Acids

Ali,

Szabó

2023

IJMS

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Biological membranes, primarily composed of lipids, envelop each living cell. The intricate composition and organization of membrane lipids, including the variety of fatty acids they encompass, serve a dynamic role in sustaining cellular structural integrity and functionality. Typically, modifications in lipid composition coincide with consequential alterations in universally significant signaling pathways. Exploring the various fatty acids, which serve as the foundational building blocks of membrane lipids, provides crucial insights into the underlying mechanisms governing a myriad of cellular processes, such as membrane fluidity, protein trafficking, signal transduction, intercellular communication, and the etiology of certain metabolic disorders. Furthermore, comprehending how alterations in the lipid composition, especially concerning the fatty acid profile, either contribute to or prevent the onset of pathological conditions stands as a compelling area of research. Hence, this review aims to meticulously introduce the intricacies of membrane lipids and their constituent fatty acids in a healthy organism, thereby illuminating their remarkable diversity and profound influence on cellular function. Furthermore, this review aspires to highlight some potential therapeutic targets for various pathological conditions that may be ameliorated through dietary fatty acid supplements. The initial section of this review expounds on the eukaryotic biomembranes and their complex lipids. Subsequent sections provide insights into the synthesis, membrane incorporation, and distribution of fatty acids across various fractions of membrane lipids. The last section highlights the functional significance of membrane-associated fatty acids and their innate capacity to shape the various cellular physiological responses.

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Sterol Digestion in Plant Sterol-Enriched Foods: Bioaccessibility and Fermentation

Blanco-Morales

García‐Llatas

Cilla

2021

Bioaccessibility and Digestibility of Lipids From Food

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Fats and Sterols

Cited by 4 publications

References 19 publications

Biomarkers predictive of long-term fertility found in vaginal lipidome of gilts at weaning

Biomarkers predictive of long-term fertility found in vaginal lipidome of gilts at weaning

Review of Eukaryote Cellular Membrane Lipid Composition, with Special Attention to the Fatty Acids

Sterol Digestion in Plant Sterol-Enriched Foods: Bioaccessibility and Fermentation

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