Fatty acid composition of adipose tissue and colorectal cancer: a case-control study

Cottet, Vanessa; Vaysse, Carole; Scherrer, M; Ortega‐Deballon, Pablo; Lakkis, Zaher; Delhorme, Jean-Baptiste; Deguelte-Lardière, S; Combe, Nicole; Bonithon‐Kopp, Claire

doi:10.3945/ajcn.114.088948

Cited by 38 publications

(32 citation statements)

References 48 publications

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“…Dietary fats are associated with a higher risk of developing colorectal cancer; in fact, a direct association between the intake of trans fatty acids and cancer has been found [10]. Increased concentrations of longchain fatty acids (LCFA) also seem to be associated with an increased risk of CRC [11]. For these reasons, many researchers have focused their attention on possible associations between CRC progression and alterations in lipid levels.…”

Section: Introductionmentioning

confidence: 98%

Altered plasma levels of decanoic acid in colorectal cancer as a new diagnostic biomarker

et al. 2016

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Colorectal cancer (CRC) is one of the most common tumors in developed countries. The five-year survival rate decreases depending on how advanced the CRC is when first diagnosed. Screening has been proven to greatly reduce mortality from colorectal cancer, but an ideal screening tool is far from being established. Here, we aimed to discover and validate early CRC biomarkers by means of an untargeted/targeted metabolomic approach. A preliminary untargeted analysis of plasma lipids performed on a small patient cohort (30 plasma samples) revealed some alterations that occurred in the presence of this tumor. In particular, medium-chain fatty acids with between six and twelve carbon atoms (C6-C12) were found to be the lipid class that showed the most marked changes upon the development of CRC. In order to evaluate the utility of this lipid class as diagnostic CRC biomarkers, a further study based on a wider cohort of patients (117 plasma samples) was performed. Using a targeted approach, these fatty acids were quantified in plasma samples by means of fast gas chromatography coupled to a time-of-flight analyzer. Plasma samples from patients with CRCs at different tumor stages were analyzed and compared to those from healthy subjects, ulcerative colitis patients, high-grade dysplasia adenoma patients, and breast cancer patients in order to test the specificity and sensitivity of these possible biomarkers. Results revealed significant differences among the considered groups in terms of their C6, C8, C10, and C12 fatty acid plasma concentrations. In particular, receiver operating characteristic (ROC) curves obtained for the C10 fatty acid gave an area under the curve of 0.8195 along with a sensitivity of 87.8 % and a specificity of 80 %, strongly suggesting that it could be a valuable early diagnostic biomarker of CRC.

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Section: Introductionmentioning

confidence: 98%

Altered plasma levels of decanoic acid in colorectal cancer as a new diagnostic biomarker

et al. 2016

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“…[8] In contrast, DHA in the plasma has shown positive correlation with tumorogenesis and development of CRC, [9] while ALA found in subcutaneous adipose tissues has displayed a negative correlation with CRC risk. [10] In addition, tumor tissues display decreased LA and increased DHLA levels, compared with surrounding normal tissues. [11] Furthermore, some additional studies have reported that administration of PUFAs (polyunsaturated fatty acids) and n-3 PUFA prevented the occurrence of gastric and CRC, while SFA and n-6 PUFA promoted development of such malignancies.…”

Section: Introductionmentioning

confidence: 99%

Abnormal octadeca-carbon fatty acids distribution in erythrocyte membrane phospholipids of patients with gastrointestinal tumor

Lin

Li²,

Liu³

et al. 2017

Medicine

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“…Although no dietary information was available for the study population, the low ω3/ω6 PUFA ratio generally observed in AT likely reflects Western dietary habits [74] . Changes in the ω3/ω6 PUFA profile (higher dihomo-γ-linolenic and docosapentaenoic acids, vs. lower α linolenic acid) were also reported in SAT from CRC patients, in association with markers of systemic inflammation [75] . The altered ω3/ω6 PUFA balance in cancer patients can markedly affect tissue composition and function as a result of the reduced protective effect of ω3 PUFA.…”

Section: Adipose Tissue Inflammation Fatty Acid Profile and Colorectmentioning

confidence: 82%

“…More recently, a general agreement has been achieved on the increased accumulation of pro-inflammatory ω6 PUFA (mostly dihomo-γ-linolenic and arachidonic acids) as well as on the unbalanced ω3/ω6 PUFA ratio in the AT of CRC patients, regardless of tumor subsite, even though differences were reported among studies on the relative abundance of individual PUFA and type of AT involved [27,[73][74][75] . In particular, a comparison of VAT and SAT FA profiles in colon cancer (CC) patients highlights a decrease of the ω3 PUFA α linolenic and stearidonic acid content, coupled to increased dihomo-γ-linolenic and arachidonic acid content in VAT of CC patients as compared to controls.…”

Section: Adipose Tissue Inflammation Fatty Acid Profile and Colorectmentioning

confidence: 94%

Dietary fatty acids and adipose tissue inflammation at the crossroad between obesity and colorectal cancer

Conti¹,

Cornò²,

Scazzocchio³

et al. 2019

JCMT

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Excess adiposity, a worldwide-growing pathological condition, is now recognized as a main risk factor for most chronic diseases including colorectal cancer (CRC). Obese subjects show an increased cancer incidence with obesity representing an important indicator of survival, prognosis, recurrence and response to therapy. A lowgrade chronic inflammation of metabolically active tissues including the adipose tissue (AT), defined as metainflammation, is a main feature of obesity. Fatty acids (FA), the main AT components, are important modulators of inflammation, and the type of FA stored in AT critically affects tissue functions. Their profile within AT mirrors FA dietary intake but also depends on a metabolic control. Obesity, changes in the habitual diet, weight loss or pathological conditions like CRC influence FA profile of AT pointing to these molecules as important actors in AT dysfunction and meta-inflammation, that characterize metabolic diseases and may favor cancer development. Worth of note, diet is receiving growing attention as a main determinant in cancer prevention due to its capacity to modulate immune response and inflammation. Alterations in the balance between different families of FA may contribute to generate a pro-inflammatory profile with deleterious effects on metabolic and immune homeostasis at both local and systemic levels. This review focuses on FA as regulators of human AT inflammation discussing the role of obesity-, diet-, and weight loss-associated changes in FA profile in this process. The relevance of FA composition of AT in linking diet, obesity and CRC will be also reviewed.

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Fatty acid composition of adipose tissue and colorectal cancer: a case-control study

Abstract: CRC patients presented higher concentrations of some FAs but lower concentrations of α-linolenic acid in their subcutaneous adipose tissue than did controls. These results may reflect both dietary patterns and altered FA metabolism but require mechanistic explorations.

Cited by 38 publications

References 48 publications

Altered plasma levels of decanoic acid in colorectal cancer as a new diagnostic biomarker

Altered plasma levels of decanoic acid in colorectal cancer as a new diagnostic biomarker

Abnormal octadeca-carbon fatty acids distribution in erythrocyte membrane phospholipids of patients with gastrointestinal tumor

Dietary fatty acids and adipose tissue inflammation at the crossroad between obesity and colorectal cancer

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