Fatty acid compositions of serum phospholipids of postmenopausal women: a comparison between Greenland inuit and Canadians before and after supplementation with fish oil

Mulvad, Gert; Park, Eek J.; Dewailly, Éric; Holub, Bruce J.

doi:10.1016/s0899-9007(02)00812-2

Cited by 33 publications

(24 citation statements)

References 23 publications

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“…Numerous reports have shown that n-3 fatty acids in phospholipids do reflect fish intake (3,8). Moreover, older Inuit (including menopausal women) generally show higher concentrations of n-3 fatty acids than do younger Inuit, older Inuit being likely to eat more traditional foods than younger Inuit (2,5,7). This last observation is consistent with previous studies conducted in northern native populations (2,5,9,10,11).…”

Section: Discussionsupporting

confidence: 90%

Very high concentrations of n-3 fatty acids in peri-and postmenopausal Inuit women from Greenland

Côté

Dodin²,

Blanchet

et al. 2004

International Journal of Circumpolar Health

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Objectives. The objectives of this study were to examine the profile of relative concentrations in plasma phospholipids of n-3 fatty acids among peri-and postmenopausal Inuit women living in Greenland and to verify their relationships with ischemic heart disease risk factors and more particularly, with concentrations of plasma triacylglycerols. Study Design. This study was part of a survey conducted in 2000, which aimed to assess the prevalence of osteoporosis and the associated risk factors among peri-and postmenopausal Greenland Inuit women. Methods. The study population consisted of 153 women aged 49-69 years (mean ± SD: 55.3 ± 4.4 y) randomly selected. Data were obtained through an interview (questionnaire on lifestyle habits, medical history etc) and a clinical session (physiologic and anthropologic measurements). Plasma samples were used to measure the fatty acid composition of plasma phospholipids. Results. The mean body mass index of women was 27.9 ± 6.1. Seventy-five percent were smokers and 9% were currently on hormone replacement therapy. Relative concentrations of total n-3 fatty acids were very high (13.8%, 95% CI: 13.1-14.6), with docosahexanoic and eicosapentanoic acids accounting for 4.7% and 7.2%, respectively. The ratio of n-3:n-6 fatty acids was 0.67. n-3 fatty acids were inversely correlated to triacylglycerols. Conclusion. These data show that peri-and postmenopausal Greenland Inuit women have very high plasma concentrations of n-3 fatty acids that protect them from ischemic heart disease.

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Section: Discussionsupporting

confidence: 90%

Very high concentrations of n-3 fatty acids in peri-and postmenopausal Inuit women from Greenland

Côté

Dodin²,

Blanchet

et al. 2004

International Journal of Circumpolar Health

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“…Furthermore, a hypothesized genetic impairment in ∆5 activity was proposed by Gibson and Sinclair (51). A few studies among Canadian Central Arctic Inuit, Canadian westcoastal Inuit and Greenland Inuit also reported similar observations, which were not explained by these populations' diets (17,52,53). While further research is warranted, it can be hypothesized that dietary transition compounded by a high prevalence of obesity among Inuit could eventually increase disease burden in this population.…”

Section: Discussionmentioning

confidence: 79%

Highly unsaturated n-3 fatty acids status of Canadian Inuit: International Polar Year Inuit Health Survey, 2007–2008

Zhou

Kubow

Egeland

2011

International Journal of Circumpolar Health

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Objectives. Previous studies suggest that dietary patterns and the extent of reliance upon traditional food vary among Inuit communities. Inuit traditional foods are an important source of nutrients such as highly unsaturated n-3 fatty acids (HUFA n-3), whose beneficial effects include protection against ischemic heart disease. Dietary transition is occurring with younger generations consuming less traditional foods and more market foods with low nutrient density. Utilizing erythrocyte membrane fatty acid composition as an indicator of body HUFA n-3 status, which reflects dietary intake levels of traditional Inuit foods, we explored the regional and age variability of highly unsaturated n-3 fatty acids (HUFA n-3) in the International Polar Year Inuit Health Survey. Study design. Cross-sectional health survey. Methods. Participants were recruited through random sampling of households. Fatty acid data were available among 2,200 adults (≥18 yr). Results. HUFA n-3 levels in the Eastern Arctic were significantly higher than in the Western Arctic, with Nunatsiavut (northern Labrador) and Baffin showing the highest HUFA n-3 status compared to Kivalliq, Kitikmeot and Inuvialuit Settlement Region (ISR) (p<0.0001). Fatty acid proportion in erythrocyte membranes showed pronounced differences between coastal communities and inland communities, including a higher HUFA n-3 status among the coastal communities (p<0.0001). Additionally, the HUFA n-3 status showed a strong positive association with age, particularly in Baffin and Kivalliq. HUFA n-3 were inversely associated with saturated (ß=-0.

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“…CHD risk was significantly lower by as much as 72% in Inuits than mainland Canadians. Mainland Canadian EPA and DHA levels (ω-3 fatty acids) were 73% and 46% lower, respectively, and Inuit LA and AA levels (ω-6 fatty acids) 32% and 91% higher, respectively [9]. Asian Indians, known to have a higher risk of CHD, had a lower ω-3/ω-6 ratio than Chinese males [13].…”

Section: Discussionmentioning

confidence: 91%

“…PUFAs of the ω-6 family produce eicosanoids (PGE2, TXA2, and LTB4) which aggregate platelet potently, constrict vessels and act as strong inflammatory cytokines. Changes in the composition of fatty acids are known to influence insulin sensitivity [8], and the ratio of ω-3 to ω-6 PUFA is associated with increased incidence of coronary heart disease (CHD) [9]. Furthermore, Giltay et al found that administration of estrogens increases DHA levels in cholesteryl esters in male-to-female transsexual subjects [10].…”

Section: Introductionmentioning

confidence: 99%

Plasma free fatty acid level patterns according to cardiovascular risk status in postmenopausal women

Rhee

Paik

Kim

et al. 2008

Clinica Chimica Acta

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Fatty acid compositions of serum phospholipids of postmenopausal women: a comparison between Greenland inuit and Canadians before and after supplementation with fish oil

Cited by 33 publications

References 23 publications

Very high concentrations of n-3 fatty acids in peri-and postmenopausal Inuit women from Greenland

Very high concentrations of n-3 fatty acids in peri-and postmenopausal Inuit women from Greenland

Highly unsaturated n-3 fatty acids status of Canadian Inuit: International Polar Year Inuit Health Survey, 2007–2008

Plasma free fatty acid level patterns according to cardiovascular risk status in postmenopausal women

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