Fatty acid conjugates of 2′-deoxy-5-fluorouridine as prodrugs for the selective delivery of 5-fluorouracil to tumor cells

Halmos, Thérèse; Moroni, Patricia; Antonakis, Kostas; Uriel, J

doi:10.1016/0006-2952(92)90048-n

Search citation statements

Order By: Relevance

Paper Sections

Select...

Introduction1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1994

2020

Publication Types

Select...

Article4

Other1

Book1

Relationship

Self Cite0

Independent6

Authors

Journals

Cited by 8 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the past, a variety of prodrugs of FUdR were synthesized to improve its physicochemical properties and reduce toxicity. In this regard, a variety of alkyl ester prodrugs (7)(8)(9)(10), phosphoramidate prodrugs (11), and photoactivated prodrugs (12) of FUdR have been investigated. Recently Xia et al synthesized dual prodrugs of FUdR by attaching well-known celldifferentiating agents such as retinoic acid to FUdR (13).…”

Section: Introductionmentioning

confidence: 99%

Untitled

Vig

Lorenzi

Mittal

et al. 2003

Pharmaceutical Research

View full text Add to dashboard Cite

Novel amino acid ester prodrugs of FUdR were successfully synthesized. The results presented here clearly demonstrate that the rate of FUdR prodrug activation in Caco-2 cell homogenates is affected by the structure, stereochemistry, and site of esterification of the promoiety. Finally, the 5'-Val and 5'-Phe monoesters exhibited desirable characteristics such as good solution stability and relatively fast enzymatic conversion rates.

show abstract