Fatty acid desaturation index correlates with body mass and adiposity indices of obesity in Wistar NIN obese mutant rat strains WNIN/Ob and WNIN/GR-Ob

Jeyakumar, Shanmugam M.; Lopamudra, Pratti; Padmini, S.; Balakrishna, Nagalla; Giridharan, Nappan Veettil; Vajreswari, Ayyalasomayajula

doi:10.1186/1743-7075-6-27

Cited by 69 publications

(53 citation statements)

References 14 publications

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“…The HCD obese control group had significantly higher adiposity index as compared to the normal control rats, which was similar to the results found in other studies (Jeyakumar et al, 2009). The A. vogelii extract produced a significant decrease in the total fat mass and adiposity index as compared to the obese controls.…”

Section: Discussionsupporting

confidence: 82%

Impact of Anthocleista vogelii root bark ethanolic extract on weight reduction in high carbohydrate diet induced obesity in male wistar rats

Anyanwu¹

2013

Afr. J. Biochem. Res.

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Obesity increases the risk of developing a number of diseases such as insulin resistance, type 2 diabetes, hypertension, hypercholesterolemia, stroke and heart attack. The aim of this study was to investigate the impact of ethanolic root bark extract of Anthocleista vogelii on weight reduction in high carbohydrate diet (HCD) induced obesity in male Wistar rats. Thirty male Wistar rats were housed in three steel cages containing 10 rats each. For the period of obesity induction, Group 1 was fed with normal pellet diet (NPD), while Groups 2 and 3 were fed with HCD for 14 weeks. During the 4 weeks treatment period, Group 1 was fed with NPD, Groups 2 and 3 were fed with HCD, and only Group 3 received 500 mg/kg b.w A. vogelii extract. The ethanolic root bark extract of A. vogelii significantly decreased (P<0.05) food intake, body weight, total fat mass, adiposity index and low density lipoprotein cholesterol, but showed no significant difference (P<0.05) in body mass index, total cholesterol, triglycerides, high density lipoprotein cholesterol, very low density lipoprotein cholesterol when compared with the HCD obese control. The results indicated that the ethanolic root bark extract of Anthocleista vogelii has potential to reduce weight in animals.

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Section: Discussionsupporting

confidence: 82%

Impact of Anthocleista vogelii root bark ethanolic extract on weight reduction in high carbohydrate diet induced obesity in male wistar rats

Anyanwu¹

2013

Afr. J. Biochem. Res.

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“…In our study, the group that received the obesogenic diet had higher visceral fat (being almost double) and liver fat weights; situation that was not reflected in peripheral fat weight (scapular and scrotal fat); this result agrees with the observations by another author (Jeyakumar et al, 2009).…”

Section: Discussionsupporting

confidence: 93%

Histomorphology of Liver, Testicle and Body Fat in Farm Rabbits Fed with an Obesogenic Diet During the Peripuberal Period

Huerta¹,

Izquierdo

Hernández³

et al. 2015

Int. J. Morphol.

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SUMMARY:Two groups were formed in order to evaluate the effect of an obesogenic diet on body and liver weight, body fat accumulation and the histometric characteristics of liver and testicles of New Zealand rabbits during the peripuberal period. One group received a standard farm diet and the other received a standard farm diet with canola oil added. During the study, weight of both groups was recorded. At the end of the study, the rabbits were euthanized and liver, testicles, and visceral, scapular and scrotal fat were weighed. Tissue samples were obtained from liver and testicles to carry out histometric analysis. Body weight, body mass index, liver and visceral fat weight were significantly different (P<0.01) in the obesogenic diet when compared to the control group. Notwithstanding, there were no significant differences between both groups in testicular weight, and scapular and scrotal fat (P>0.01). Histometry of the liver of the obesogenic diet group showed the greater total area and greater nucleus area of hepatocytes in the square lobe, right lobe and left lobe medial segment (P<0.01). Histometry of both testicles of individuals from the obesogenic diet group had a greater germinal epithelial thickness and intertubular intersticium (P<0.01). It is concluded that New Zealand male rabbits that received an obesogenic diet during 12 weeks had a higher liver and body weight, as well as, an important increased visceral fat. Furthermore, said diet caused histometric changes in liver and testicles. This set confirms that the domestic rabbit is a good model for the study of the body fat accumulation process associated to the consumption of an obesogenic diet and its effects on liver and testicles.

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“…The sum of the fat pads determined the total visceral fat weight. The adiposity index was calculated as the result of the total fat pad (g) divided by the final bodyweight × 100 and expressed as adiposity percent (Jeyakumar et al, 2009). …”

Section: Fat Pads and Gastrocnemiusmentioning

confidence: 99%

Aqueous extract of Chrysobalanus icaco leaves, in lower doses, prevent fat gain in obese high-fat fed mice

White

Cercato

Batista

et al. 2016

Journal of Ethnopharmacology

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Fatty acid desaturation index correlates with body mass and adiposity indices of obesity in Wistar NIN obese mutant rat strains WNIN/Ob and WNIN/GR-Ob

Cited by 69 publications

References 14 publications

Impact of Anthocleista vogelii root bark ethanolic extract on weight reduction in high carbohydrate diet induced obesity in male wistar rats

Impact of Anthocleista vogelii root bark ethanolic extract on weight reduction in high carbohydrate diet induced obesity in male wistar rats

Histomorphology of Liver, Testicle and Body Fat in Farm Rabbits Fed with an Obesogenic Diet During the Peripuberal Period

Aqueous extract of Chrysobalanus icaco leaves, in lower doses, prevent fat gain in obese high-fat fed mice

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