Fatty acid oxidation affects food intake by altering hepatic energy status

Friedman, Mark I.; Harris, Ruth B. S.; Hong, Ji Man; Ramírez, Israel; Tordoff, Michael G.

doi:10.1152/ajpregu.1999.276.4.r1046

Cited by 78 publications

(86 citation statements)

References 20 publications

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“…In contrast, inhibition of peripheral fatty acid and carbohydrate oxidation increases feed intake (Friedman et al, 1999;Del Prete et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…In addition to these humoral signals, metabolic oxidation in peripheral organs, specifically fatty acid oxidation in the liver, intestine, and muscle (Scharrer and Langhans, 1986;Friedman et al, 1999;Langhans et al, 2011) and carbohydrate oxidation, primarily he-patic and muscular glycolysis (Friedman and Tordoff, 1986), signal through the autonomous nervous system to the brain for terminating feed intake. In contrast, inhibition of peripheral fatty acid and carbohydrate oxidation increases feed intake (Friedman et al, 1999;Del Prete et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Short-term feed intake is regulated by macronutrient oxidation in lactating Holstein cows

Derno

Nürnberg

Schön

et al. 2013

Journal of Dairy Science

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In addition to plasma metabolites and hormones participating as humoral signals in the control of feed intake, oxidative metabolic processes in peripheral organs also generate signals to terminate feeding. Although the degree of oxidation over longer periods is relatively constant, recent work suggests that the periprandial pattern of fuel oxidation is involved in regulating feeding behavior in the bovine. However, the association between periprandial oxidative metabolism and feed intake of dairy cows has not yet been studied. Therefore, the aim of this study was to elucidate possible associations existing between single feed intake events and whole-body net fat and net carbohydrate oxidation as well as their relation to plasma metabolite concentrations. To this end, 4 late-lactating cows equipped with jugular catheters were kept in respiratory chambers with continuous and simultaneous recording of gas exchange and feed intake. Animals were fed ad libitum (AL) for 24 h and then feed restricted (RE) to 50% of the previous AL intake for a further 24 h. Blood samples were collected hourly to analyze β-hydroxybutyrate (BHBA), glucose, nonesterified fatty acids (NEFA), insulin, and acylated ghrelin concentrations. Crosscorrelation analysis revealed an offset ranging between 30 and 42 min between the maximum of a feed intake event and the lowest level of postprandial net fat oxidation (FOX net ) and the maximum level of postprandial net carbohydrate oxidation (COX net ), respectively. During the AL period, FOX net did not increase above −0.2 g/min, whereas COX net did not decrease below 6 g/min before the start of the next feed intake event. A strong inverse cross-correlation was obtained between COX net and plasma glucose concentration. Direct cross-correlations were observed between COXnet and insulin, between heat production and BHBA, between insulin and glucose, and between BHBA and ghrelin. We found no cross-correlation between FOX net and NEFA. During RE, FOX net increased with an exponential slope, exceeded the threshold of −0.2 g/min as indicated by increasing plasma NEFA concentrations, and approached a maximum rate of 0.1 g/min, whereas COX net decayed in an exponential manner, approaching a minimal COX net rate of about 2.5 g/min in all cows. Our novel findings suggest that, in late-lactating cows, postprandial increases in metabolic oxidative processes seem to signal suppression of feed intake, whereas preprandially an accelerated FOX net rate and a decelerated COX net rate initiate feed intake.

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“…In contrast, inhibition of peripheral fatty acid and carbohydrate oxidation increases feed intake (Friedman et al, 1999;Del Prete et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Short-term feed intake is regulated by macronutrient oxidation in lactating Holstein cows

Derno

Nürnberg

Schön

et al. 2013

Journal of Dairy Science

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“…Essa redução pode induzir à oxidação de outros substratos energéticos como rota metabólica compensatória e alterar o metabolismo energético. Por isso, com a redução de reservas energéticas, principalmente glicogênica, há aumento do consumo de matéria seca para regular o metabolismo energético (Friedman et al, 1999).…”

Section: Resultsunclassified

Digestibilidade e metabolismo de dietas de suínos contendo zearalenona com adição de organoaluminossilicato

Hauschild

Lovatto

Lehnen

et al. 2007

Pesq. agropec. bras.

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Resumo -Um experimento foi realizado para avaliar a digestibilidade de dietas e balanços metabólicos de suínos alimentados com dietas contendo zearalenona (ZEA) com e sem adição de organoaluminossilicato (OA). Foram utilizadas 12 leitoas com peso inicial de 12 kg, alojadas em gaiolas metabólicas. O delineamento foi inteiramente casualizado, com três tratamentos (controle, controle + 2 ppm de ZEA e controle + 2 ppm de ZEA com adição de 0,3% de OA na dieta) e quatro repetições, com o animal como unidade experimental. A ZEA e o OA não influenciaram (p>0,05) o consumo de matéria seca, a digestibilidade da matéria seca e energia bruta, metabolização da energia, proteína digestível e energias digestível e metabolizável das dietas. A ZEA e OA não alteraram o balanço do N (p>0,05), mas modificaram (p<0,05) a excreção fecal de P. Nas dietas contendo ZEA e ZEA+OA, a excreção fecal de P foi 15 e 10% menor do que no grupo controle. A ZEA e o OA não alteraram (p>0,05) a absorção de P em função da ingestão. O consumo de 2 ppm de ZEA com ou sem adição de 0,3% de OA não interfere na digestibilidade das dietas e no metabolismo dos suínos.Termos para indexação: adsorvente, energia, micotoxinas, nitrogênio. Digestibility and metabolism of piglet diets containing zearalenone with addition of organoaluminosilicateAbstract -An experiment was carried out to asses diet digestibility and metabolism balance of piglets fed on diets containing zearalenone (ZEA) with and without addition of organaluminisilicate (OA). Twelve gilts littermates were used, with 12 kg initial body weight, housed in metabolic cages. A completely randomized design was used and comprised three treatments (control, control + 2 ppm ZEA, and control + 2 ppm ZEA with addition of 0.3% of OA), and four replications, being the animal as experimental unit. The ZEA and the OA did not affect (p>0.05) dry matter intake, digestibility of dry matter and gross energy, metabolizable energy, digestible energy as well as digestible protein. The nitrogen balance was not modified (p>0.05) by ZEA and OA. However, it influenced (p<0.05) the fecal excretion of P. In diets containing ZEA and ZEA+OA, fecal excretion of P was 15 and 10% lower than the control group. The ZEA and the OA did not affect (p>0.05) the absorption of P in relation to the ingestion. The intake of 2 ppm of ZEA with or without addition of 0.3% of OA in diet does not affect the digestibility of diets and the metabolism of pigs.

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“…In fact, a lower secretion of GIP, which is a hormone with possible actions in the food intake regulation, were observed in the HTG group. Moreover, higher TG levels after a meal could be related to limited TG metabolization by the organism, which would stimulate food intake (29). This might point to difficult energy storage in the adipocytes, which could trigger Postprandial GIP and GLP-1 response along time in LTH and HTG groups (*significant difference between the groups).…”

Section: Discussionmentioning

confidence: 99%

Effects of a high-fat meal on postprandial incretin responses, appetite scores and ad libitum energy intake in women with obesity

et al. 2017

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Penaforte FRO, Japur CC, Diez-Garcia RW, Chiarello PG. Effects of a high-fat meal on postprandial incretin responses, appetite scores and ad libitum energy intake in women with obesity. AbstractBackground: Considering the possible role of triglycerides (TG), glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) in the regulation of appetite, this study aimed to compare high fat meal-induced response of GIP and GLP-1, appetite scores and ad libitum energy intake in women with obesity, according to postprandial increment in triglyceridemia (∆TG). Methods: Thirty-three no-diabetic women (BMI = 35.0 ± 3.2 kg.m

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Fatty acid oxidation affects food intake by altering hepatic energy status

Cited by 78 publications

References 20 publications

Short-term feed intake is regulated by macronutrient oxidation in lactating Holstein cows

Short-term feed intake is regulated by macronutrient oxidation in lactating Holstein cows

Digestibilidade e metabolismo de dietas de suínos contendo zearalenona com adição de organoaluminossilicato

Effects of a high-fat meal on postprandial incretin responses, appetite scores and ad libitum energy intake in women with obesity

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