Fatty Acid Profile and Genetic Variants of Proteins Involved in Fatty Acid Metabolism Could Be Considered as Disease Predictor

Chaaba, R.; Bouaziz, Aicha; Amor, Asma Ben; Mnif, Wissem; Hammami, Mohamed; Mehri, Sounira

doi:10.3390/diagnostics13050979

Cited by 10 publications

(1 citation statement)

References 122 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Нуклеотидный вариант («G» или «А») в точке полиморфизма Ala54Thr (G163A) rs1799883 в этом гене приводит к синтезу разных вариантов белка. Один из них лучше связывается с жирными кислотами и, соответственно, люди с таким вариантом гена (генотип GA или AA полиморфизма rs1799883) эффективней усваивают жиры из потребляемой пищи, имеют более высокий ИМТ по сравнению с обладателями альтернативного варианта гена FABP2 [17].…”

Section: оригинальные исследования Original Researchunclassified

Study of association of the polymorphism rs1799883 of the <i>FABP2</i> gene in children with bronchial asthma associated with obesity

Telepneva,

Evseeva,

Nagovitsyna

et al. 2023

Bûlletenʹ fiziologii i patologii dyhaniâ

View full text Add to dashboard Cite

Introduction. Currently, there is a separate phenotype “bronchial asthma – obesity”, manifested by a more severe course of the disease, low rates of achieving asthma control, resistance to basic therapy. Asthma, like obesity, is recognized as a classic example of multifactorial diseases, which are based on a rather complex gene network. The active search for genetic markers characterizing individual characteristics of human metabolism continues. Of particular interest are the genes involved in the regulation of fat and carbohydrate metabolism.Aim. Analysis of associations of polymorphic loci Ala54Thr (G163A) of the FABP2 gene with bronchial asthma of varying severity and control of asthma in children.Materials and methods. 161 children with bronchial asthma in remission were examined by a continuous sampling method, of which 59 patients with obesity of 1-3 degrees without concomitant endocrine pathology. The examination included general clinical, functional, and instrumental methods. The level of asthma control was determined according to the GINA criteria (2018). The biochemical study was carried out on an automatic analyzer SAPPHIRE 400 (Japan). The study of gene polymorphisms was carried out by real-time polymerase chain reaction using sets of “Metabolism” (Research and Production Company “Litekh”, Moscow) on the CFX-96 Biorat device (USA).Results. We have not identified associations of the presence of polymorphic loci of the FABP2 gene with obesity. It was determined that in children with bronchial asthma, the frequency of carrying the homozygous genotype Thr/Thr and the minor allele Thr increased by 1.5 times compared to the control group (OR 9.043; 95%CI [2,093–39,073], p=0.0011 and OR 2.946; 95%CI [1,698‒5,111], p=0.001, respectively), and in children with bronchial asthma with and without asthma control, the carriage of the homozygous Thr/Thr genotype and the rare A allele increased the risk of uncontrolled bronchial asthma (OR 2.42; 95%CI [1.23‒4.79], p=0.03 and OR 1.75; 95%CI [1,119‒2,736], p=0.01), the frequency of the homozygous Ala/Ala genotype and the frequent Ala allele was detected 1.5 times more often in children with bronchial asthma associated with obesity (OR 2.176; 95%CI [1.001‒4.727], p=0.0008 and OR 2.378; 95%CI [1.495‒3.780], p=0.0002, respectively).Conclusion. Although we have not identified associations of the presence of polymorphic loci of the FABP2 gene with obesity, it has been shown that children with Ala54Thr+Thr54Тhr genotypes have significantly higher glucose levels (4.9±0.06 mmol/L compared with carriers of the Ala54Ala genotype 4.0±0.06 mmol/L, p<0.001), cholesterol (4.8±0.4 mmol/L compared with carriers of the Ala54Ala genotype 3.93±0.1 mmol/L, p<0.05) and low density lipoproteins (2.55±0.09 mmol/L compared with carriers of the Ala54Ala genotype 2.26±0.1 mmol/L, p<0.05). There is an obvious need for further investigation of the effect of gene polymorphism on the indicators of carbohydrate and lipid metabolism, depending on the nature of diets. These issues require further study as part of the search for probable cause-and-effect relationships and the creation of personalized programs depending on polymorphic gene variants.

show abstract

Section: оригинальные исследования Original Researchunclassified

Study of association of the polymorphism rs1799883 of the <i>FABP2</i> gene in children with bronchial asthma associated with obesity

Telepneva,

Evseeva,

Nagovitsyna

et al. 2023

Bûlletenʹ fiziologii i patologii dyhaniâ

View full text Add to dashboard Cite

show abstract

AIE‐Based Sensor Combination for Oleic Acid/Elaidic Acid Discriminating and Sensing

Shi,

Yang,

et al. 2024

ChemistrySelect

View full text Add to dashboard Cite

Two aggregation induced emission molecules (TPE‐MZ and QM‐Py‐TPE) have been synthesized and characterized. Similar to conventional AIE based molecules, both molecules displayed good sensitivity towards water fraction and viscosity of dispersing medium. The fluorescent emission intensity of TPE‐MZ gradually reduced with increasing concentration of oleic acid and elaidic acid within the range of 0.2–5 mM. The inflection points of TPE‐MZ fluorescent emission maximum for oleic acid and elaidic acid were observed at 1.40 and 0.80 mM, respectively. The corresponding inflection points of QM‐Py‐TPE were 1.80 and 2.00 mM for oleic acid and elaidic acid, respectively. Sensor combination (TPE‐MZ:QM‐Py‐TPE=2 : 1) emitted pink and yellow fluorescence in elaidic and oleic acid. Fluorescent emission ratio of I646/I508 of sensor combination displayed acceptable linear relationship (R2=0.9826) with concentration of oleic acid (within the concentration of 4 mM). Thus, the sensor combination was capable of oleic acid and elaidic acid naked‐eye discriminating and quantitively sensing.

show abstract

Punicalagin relieves lipotoxic injuries on pancreatic β-cells via regulating the oxidative stress and endoplasmic reticulum stress-mediated apoptosis

Wang,

Yang,

Wang

et al. 2023

In Vitro Cell.Dev.Biol.-Animal

View full text Add to dashboard Cite

Fatty Acid Profile and Genetic Variants of Proteins Involved in Fatty Acid Metabolism Could Be Considered as Disease Predictor

Cited by 10 publications

References 122 publications

Study of association of the polymorphism rs1799883 of the <i>FABP2</i> gene in children with bronchial asthma associated with obesity

Study of association of the polymorphism rs1799883 of the <i>FABP2</i> gene in children with bronchial asthma associated with obesity

AIE‐Based Sensor Combination for Oleic Acid/Elaidic Acid Discriminating and Sensing

Punicalagin relieves lipotoxic injuries on pancreatic β-cells via regulating the oxidative stress and endoplasmic reticulum stress-mediated apoptosis

Contact Info

Product

Resources

About