1993
DOI: 10.1172/jci116652
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Fatty acids are required for epidermal permeability barrier function.

Abstract: The permeability barrier is mediated by a mixture of ceramides, sterols, and free fatty acids arranged as extracellular lamellar bilayers in the stratum corneum. Whereas prior studies have shown that cholesterol and ceramides are required for normal barrier function, definitive evidence for the importance of nonessential fatty acids is not available. To determine whether epidermal fatty acid synthesis also is required for barrier homeostasis, we applied 5-(tetradecyloxy)-2-furancarboxylic acid (TOFA), an inhib… Show more

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Cited by 156 publications
(121 citation statements)
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“…The initial wave of lamellar body secretion occurs normally, but the ability of the epidermis to synthesize new lamellar bodies is impaired and those lamellar bodies that are formed display abnormal lamellar membranes. These abnormalities in barrier repair and lamellar body formation can be reversed by topical treatment with free fatty acids, indicating that these defects are not the nonspecific effects of TOFA (85). These results demonstrate an important role for epidermal de novo fatty acid synthesis in permeability barrier homeostasis.…”
Section: Jlr: Is Fatty Acid Synthesis In the Epidermis Also Importantmentioning
confidence: 70%
See 2 more Smart Citations
“…The initial wave of lamellar body secretion occurs normally, but the ability of the epidermis to synthesize new lamellar bodies is impaired and those lamellar bodies that are formed display abnormal lamellar membranes. These abnormalities in barrier repair and lamellar body formation can be reversed by topical treatment with free fatty acids, indicating that these defects are not the nonspecific effects of TOFA (85). These results demonstrate an important role for epidermal de novo fatty acid synthesis in permeability barrier homeostasis.…”
Section: Jlr: Is Fatty Acid Synthesis In the Epidermis Also Importantmentioning
confidence: 70%
“…First, in the inhibitor experiments described above, despite a marked inhibition of lipid synthesis (e.g., topical statin treatment acutely inhibited cholesterol synthesis by .90%), the inhibition of permeability barrier recovery is relatively modest (81,85,114). This discrepancy suggests that alternative sources of lipid are available for the formation of lamellar bodies and the regeneration of stratum corneum lipid membranes.…”
Section: Jlr: Are Extracutaneously Derived Lipids Important For Permementioning
confidence: 98%
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“…Lipids are major components of the cornified envelope and are crucial for barrier formation (1,26); this provides a plausible reason why the fatty acid transport properties of FATP4 could play a role in establishment or maintenance of the barrier. We therefore hypothesized that lipid homeostasis was affected in Slc27a4 wrfr Ϫ͞Ϫ skin.…”
Section: Fatp4mentioning
confidence: 99%
“…Chloroalanine, inhibitor of SPT, has been used to investigate the role of skin sphingosine synthesis inhibition in the permeation of levodopa, a hydrophilic drug, across rat skin [89]. Moreover beta-chloroalanine causes paradoxical effects on barrier permeability homeostasis [90] and delays mammalian epidermal barrier recovery after acute perturbation [91].…”
Section: Membrane Structure and Functionmentioning
confidence: 99%