Fatty acids' double role in the prebiotic formation of a hydrophobic dipeptide

Murillo-Sánchez, Sara; Beaufils, Damien; Mañas, Juan Manuel González; Pascal, Robert; Ruiz-Mirazo, Kepa

doi:10.1039/c5sc04796j

Cited by 50 publications

(47 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It also strengthens additional advantagesi nt erms of functiont hat can be obtained by associating amino acids with membranes or nucleic acids that have already been observed in our group as well as by others. [9][10][11][12] Diversity in prebiotic "clutter" [56] can also present advantages in terms of as elf-organization process. The emergence of translation may therefore lie in the intimate chemistry of RNA and the specific behavior of the intramolecular transfer in 3'phosphorylated RNA as well as in the very specific behavior of the ribose 2'-and 3'-hydroxyl groups.…”

Section: Resultsmentioning

confidence: 99%

“…The question of the origin of life is now considered as that of co-evolution of different subsystems rather than as elf-organization process in as ystem made of as ingle biopolymer.I th as therefore been considered as ac o-evolutionary process [1][2][3] that overcomes the difficulties associated with past views on the origin of lifes tartingf rom as ingle kind of biopolymer.P revious review articles have demonstrated the advantages that could be expected from system chemistry views [4,5] associating differents ubsystems with each other. [6,7] Experimental approaches have indeed shown the benefits resulting from the association of components coming from different subsystems for self-organization, as in the cases of the combination of peptides andn ucleotides, [8] peptides and lipids, [9] or nucleic bases and fatty acids. [10] As trong support to these views has recently been brought about by the discovery that most of the essential building blockso fb iochemistry can be formed from very similar processes possibly occurring in the same location.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mixed Anhydride Intermediates in the Reaction of 5(4H)‐Oxazolones with Phosphate Esters and Nucleotides

Liu

Rigger

Rossi

et al. 2016

Chemistry A European J

Self Cite

View full text Add to dashboard Cite

Abstract5(4H)‐Oxazolones can be formed through the activation of acylated α‐amino acids or of peptide C termini. They constitute potentially activated intermediates in the abiotic chemistry of peptides that preceded the origin of life or early stages of biology and are capable of yielding mixed carboxylic‐phosphoric anhydrides upon reaction with phosphate esters and nucleotides. Here, we present the results of a study aimed at investigating the chemistry that can be built through this interaction. As a matter of fact, the formation of mixed anhydrides with mononucleotides and nucleic acid models is shown to take place at positions involving a mono‐substituted phosphate group at the 3’‐ or 5’‐terminus but not at the internal phosphodiester linkages. In addition to the formation of mixed anhydrides, the subsequent intramolecular acyl or phosphoryl transfers taking place at the 3’‐terminus are considered to be particularly relevant to the common prebiotic chemistry of α‐amino acids and nucleotides.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mixed Anhydride Intermediates in the Reaction of 5(4H)‐Oxazolones with Phosphate Esters and Nucleotides

Liu

Rigger

Rossi

et al. 2016

Chemistry A European J

Self Cite

View full text Add to dashboard Cite

show abstract

“…18 As argued in Ruiz-Mirazo and Moreno (2013). Examples of this use of definitions are Guiloff (1981), Fleischaker (1990), Luisi (1993), Murillo-Sanchez et al (2016). Stano and Mavelli (2015).…”

Section: General Roles and Applications In Different Fields At The Frmentioning

confidence: 99%

Is defining life pointless? Operational definitions at the frontiers of biology

Bich

Green

2017

Synthese

View full text Add to dashboard Cite

Despite numerous and increasing attempts to define what life is, there is no consensus on necessary and sufficient conditions for life. Accordingly, some scholars have questioned the value of definitions of life and encouraged scientists and philosophers alike to discard the project. As an alternative to this pessimistic conclusion, we argue that critically rethinking the nature and uses of definitions can provide new insights into the epistemic roles of definitions of life for different research practices. This paper examines the possible contributions of definitions of life in scientific domains where such definitions are used most (e.g., Synthetic Biology, Origins of Life, Alife, and Astrobiology). Rather than as classificatory tools for demarcation of natural kinds, we highlight the pragmatic utility of what we call operational definitions that serve as theoretical and epistemic tools in scientific practice. In particular, we examine contexts where definitions integrate criteria for life into theoretical models that involve or enable observable operations. We show how these definitions of life play important roles in influencing research agendas and evaluating results, and we argue that to discard the project of defining life is neither sufficiently motivated, nor possible without dismissing important theoretical and practical research.

show abstract

“…10 Fmoc (9-fluorenylmethyloxycarbonyl) group contributes to enhance the self-assembly of the dipeptides onto well-defined nanostructures through solvophobic interactions, also providing amphiphilic character. [11][12][13] Selfassembly of Fmoc-dipeptides in bulk solution is able to render nanowires with excellent chirality and energy transfer features. 14,15 Intriguingly, self-assembled nanowires of dipeptides are connected to the core recognition motif in Alzheimer disease.…”

Section: Introductionmentioning

confidence: 99%