Fatty acids: facts vs. fiction

Abstract

Abstract. During the last 100 years official dietary guidelines have recommended an increased consumption of fats derived from seeds while decreasing the consumption of traditional fats, especially saturated fats. These recommendations are being challenged by recent studies. Furthermore, the increased use of refining processes in fat production had deleterious health effects. Today, the number of high-quality studies on fatty acids is large enough to make useful recommendations on clinical application and everyday practice. Saturated fats have many beneficial functions and palmitic acid appears to be problematic only when it is synthesized due to excess fructose consumption. Trans fatty acids were shown to be harmful when they are manmade but beneficial when of natural origin. Conjugated linoleic acid has many benefits but the isomer mix that is available in supplement form differs from its natural origin and may better be avoided. The ω3 fatty acid linolenic acid has rather limited use as an anti-inflammatory agent – a fact that is frequently overlooked. On the other hand, the targeted use of long chain ω3 fatty acids based on blood analysis has great potential to supplement or even be an alternative to various pharmacological therapies. At the same time ω6 fatty acids like linoleic acid and arachidonic acid have important physiological functions and should not be avoided but their consumption needs to be balanced with long chain ω3 fatty acids. The quality and quantity of these fats together with appropriate antioxidative protection are critical for their positive health effects.

Linoleic acid improves Piezo 2 dysfunction in a mouse model of Angelman syndrome

“…Importantly, we have identified a fatty acid (LA) that increases PIEZO2 mechanocurrents. The ω-6 fatty acid LA, a structural component of membrane phospholipids, is an essential PUFA enriched in safflower, soybean, sunflower, corn, and canola oils [59][60][61] . In this work, we used a nonwestern-style diet enriched with 59% of fat-derived calories from safflower oil as a delivery method to maximize the LA content.…”

“…A linoleic acid-enriched diet recovers Ube3a m-/p+ neuronal mechano-currents and -excitability LA is an essential ω-6 fatty acid and a structural component of plasma membranes 58 . It is commonly found in safflower, soybean, sunflower, corn, and canola oils [59][60][61] . Since LA supplementation in the culture media increases mechanocurrents, we postulated that including LA in the animal's diet may rescue the mechano-deficits of Ube3a m-/p+ DRG neurons.…”

Fatty Acids Profile and the Relevance of Membranes as the Target of Nutrition-Based Strategies in Atopic Dermatitis: A Narrative Review

“…The PUFA omega-6 and omega-3 pathways with their insertion in membrane phospholipids and production of eicosanoid mediators are shown in Figure 2 [75]. The most common omega-6 PUFA in foods is linoleic acid (LA, C18:2).…”

Cuerpos lipídicos y estrés oxidante

“…En cuanto a su estructura química, forman diversos grupos, con distribución y funciones celulares diversas. Es posible revisar la información detallada respecto de la estructura y función de los diferentes tipos de lípidos en diversas fuentes(Alberts et al, 2014, p.566;Chong et al, 2006;Waehler, 2021). En este trabajo, nos centraremos en los ácidos grasos, ya que la mayoría de los lípidos se derivan de ellos, y son el principal blanco de las ERO.Los ácidos grasos forman parte tanto de los triglicéridos como de los lípidos complejos y pueden esterificar el colesterol; los de interés biológico son aquellos formados por 4 a 26 átomos de carbono.…”