Garden cress (Lepidium sativum L.) belonging to Cruciferae family is widely grown in India, Europe, and United States. It has been used as an important medicinal plant since the Vedic era. Its seed, oil, and powder contain signiicant amount of protein, fat, minerals, ibers, and phytochemicals, which are incorporated in many functional beverages and foods. A number of clinical trials have been conducted on rats that also support the eicacy of garden cress seeds (GCSs). The seed of garden cress was used in the fortiication of diferent food items but due to the lack of their physicochemical properties and medicinal value, the exploration of the potential of garden cress seed was limited. In the present review, we discuss the proximate chemical composition, physicochemical, medicinal properties, and the food product development with garden cress seed. The functional properties of garden cress seed stimulate us to review its diferent valuable properties and the fortiied products developed by incorporating garden cress seeds.