Fatty Acids Intake and Depressive Symptomatology in a Greek Sample: An Epidemiological Analysis

Panagiotakos, Demosthenes B.; Mamplekou, Efterpi; Pitsavos, Christos; Kalogeropoulos, Nick; Kastorini, Christina-Maria; Papageorgiou, Charalabos; Papadimitriou, George N.; Stefanadis, Christodoulos

doi:10.1080/07315724.2010.10719897

Cited by 29 publications

(25 citation statements)

References 44 publications

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“…Conversion of ALA to DHA is higher in women than men [29]. But, some studies found no sex-based differences [30], some found opposite sex effect [31]. There have also been few studies that examined the effect of ω-3 PUFA supplementation on mood in young healthy populations.…”

Section: Discussionmentioning

confidence: 99%

Effects of Walnut Consumption on Mood in Young Adults—A Randomized Controlled Trial

Pribis

2016

Nutrients

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Walnuts contain a number of potentially neuroprotective compounds like vitamin E, folate, melatonin, several antioxidative polyphenols and significant amounts of ω-3 fatty acids. The present study sought to determine the effect of walnuts on mood in healthy volunteers. Sixty-four college students were randomly assigned to two treatment sequences in a crossover fashion: walnut–placebo or placebo–walnut. At baseline mood was assessed using Profiles of Mood States (POMS). Data was collected again after eight weeks of intervention. After six-weeks of washout, the intervention groups followed the diets in reverse order. Data was collected once more at the end of the eight-week intervention period. No significant changes in mood were observed in the analyses with both genders combined and in females. However, we have observed a significant medium effect size improvement in the Total Mood Disturbance score (−27.49%, p = 0.043, Cohen’s d = 0.708) in males. In non-depressed healthy young males, walnuts seem to have the ability to improve mood.

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Section: Discussionmentioning

confidence: 99%

Effects of Walnut Consumption on Mood in Young Adults—A Randomized Controlled Trial

Pribis

2016

Nutrients

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“…Our findings demonstrated that women with higher consumptions of ALA were less likely to have depressive symptoms. A study by Panagiotakos et al (2010) in 853 healthy adults from the province of Attica found that increases in plasma total PUFA, total MUFA, total n-3 FA, DHA, EPA, LA and ALA were all associated with lower scores on Zung's Self-rating Depression Scale (40) . To the authors' knowledge, no one has previously shown an association between dietary intakes of ALA and reduced risk of depression using the SF-36 MH subscale and CESD-10 validated screening measures.…”

Section: Discussionmentioning

confidence: 99%

Unsaturated fat intakes and mental health outcomes in young women from the Australian Longitudinal Study on Women’s Heath

Daley

Patterson

Sibbritt

et al. 2014

Public Health Nutr.

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Results: Adjusted logistic regression analyses found statistically significant associations between higher intakes of α-linolenic acid and decreased likelihood of depressive symptoms indicated by the ten-item Center for Epidemiological Studies Depression Scale (CESD-10; OR = 0·77; 95 % CI 0·60, 0·99; P = 0·040) and the Short Form Health Survey (SF-36) mental health subscale (OR = 0·73 95 % CI 0·56, 0·96; P = 0·024). Furthermore, higher intakes of n-6 fatty acids (OR = 0·96, 95 % CI 0·93, 0·99; P = 0·019) and linoleic acid (OR = 0·96, 95 % CI 0·93, 0·99; P = 0·020) were associated with decreased likelihood of self-reported diagnosed anxiety and higher intakes of n-9 fatty acids (OR = 1·02, 95 % CI 1·00, 1·04; P = 0·041) and oleic acid (OR = 1·02, 95 % CI 1·00, 1·05; P = 0·046) were associated with increased likelihood of self-reported diagnosed anxiety. Conclusions:: Increased intakes of α-linolenic acid were associated with a reduced likelihood of depressive symptoms, increased intakes of n-6 fatty acids and linoleic acid were associated with a reduced likelihood of self-reported anxiety, and increased intakes of n-9 fatty acids and oleic acid were associated with an increased likelihood of anxiety. Additional studies are needed to further elucidate associations between unsaturated fatty acids and depression and anxiety.

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“…Moreover, in one randomized study magnesium proved to be comparably effective in the treatment of depression as imipramine, which is an extensively used, tricyclic and highly effective antidepressant drug [111]. Therefore it has been hypothesized that oral administration of magnesium might support an antidepressant effect [112,113].…”

Section: Special Nutritional Compounds Which Could Influence Depressimentioning

confidence: 99%

“…Increased polyunsaturated fatty acid (PUFA) and monounsaturated fatty acid (MUFA) concentrations, and high concentrations of plasma total n-3 fatty acids, docosahexaenoic acid, eicosapentaenoic acid, α-linoleic acid, and linoleic acid, were associated with lower scores in the depression scale used [113,114]. Accordingly, fish consumption has been associated with resilience to depression [115].…”

Section: Special Nutritional Compounds Which Could Influence Depressimentioning

confidence: 99%

Nutritional Aspects of Depression

Lang

Beglinger

Schweinfurth

et al. 2015

Cell Physiol Biochem

216

134

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Several nutrition, food and dietary compounds have been suggested to be involved in the onset and maintenance of depressive disorders and in the severity of depressive symptoms. Nutritional compounds might modulate depression associated biomarkers and parallel the development of depression, obesity and diabetes. In this context, recent studies revealed new mediators of both energy homeostasis and mood changes (i.e. IGF-1, NPY, BDNF, ghrelin, leptin, CCK, GLP-1, AGE, glucose metabolism and microbiota) acting in gut brain circuits. In this context several healthy foods such as olive oil, fish, fruits, vegetables, nuts, legumes, poultry, dairy and unprocessed meat have been inversely associated with depression risk and even have been postulated to improve depressive symptoms. In contrast, unhealthy western dietary patterns including the consumption of sweetened beverage, refined food, fried food, processed meat, refined grain, and high fat diary, biscuits, snacking and pastries have been shown to be associated with an increased risk of depression in longitudinal studies. However, it is always difficult to conclude a real prospective causal relationship from these mostly retrospective studies as depressed individuals might also change their eating habits secondarily to their depression. Additionally specific selected nutritional compounds, e.g. calcium, chromium, folate, PUFAs, vitamin D, B12, zinc, magnesium and D-serine have been postulated to be used as ad-on strategies in antidepressant treatment. In this context, dietary and lifestyle interventions may be a desirable, effective, pragmatical and non-stigmatizing prevention and treatment strategy for depression. At last, several medications (pioglitazone, metformin, exenatide, atorvastatin, gram-negative antibiotics), which have traditionally been used to treat metabolic disorders showed a certain potential to treat depression in first randomized controlled clinical trials.

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Fatty Acids Intake and Depressive Symptomatology in a Greek Sample: An Epidemiological Analysis

Abstract: These results indicate that increased PUFA and MUFA concentrations are associated with diminished depressive symptomatology among apparently healthy adults.

Cited by 29 publications

References 44 publications

Effects of Walnut Consumption on Mood in Young Adults—A Randomized Controlled Trial

Effects of Walnut Consumption on Mood in Young Adults—A Randomized Controlled Trial

Unsaturated fat intakes and mental health outcomes in young women from the Australian Longitudinal Study on Women’s Heath

Nutritional Aspects of Depression

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