Fatty Exosomes Aggravate Metabolic Disorders

Abstract

Fatty exosomes are secreted from patients with metabolic syndrome. The secretion processes and the composition of secreted lipids and biomolecules, are altered in exosomes. Since fatty exosomes can induce insulin resistance, glucose intolerance, inflammation, and fatty liver disease, elucidating the pathophysiological role of them and their promising targets for reversing undesirable effects will be essential for developing therapies for metabolic complications. STOM, stomatin; DRAM, damage-regulated autophagy modulator; FFA, free fatty acid; FA, fatty acid; PE, phosphatidylethanolamine; PC, phosphatidylcholine.