Fatty fish, hair mercury and cognitive function in Norwegian preschool children: Results from the randomized controlled trial FINS-KIDS

Kvestad, Ingrid; Vabø, Silje; Kjellevold, Marian; Nøstbakken, Ole Jakob; Midtbø, Lisa Kolden; Hysing, Mari; Markhus, Maria Wik; Madsen, Lise; Handeland, Katina; Graff, Ingvild Eide; Lie, Øyvind; Frøyland, Livar; Stormark, Kjell Morten; Dahl, Lisbeth; Øyen, Jannike

doi:10.1016/j.envint.2018.10.022

Cited by 12 publications

(41 citation statements)

References 35 publications

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“…Four studies were prospective cohort trials [14,45,49,51], and five were case control studies [47,53,54,57,58]. Seven were reports from three RCTs: the FINS-KIDS study produced three manuscripts [48,50,52] and the FINS-TEENS study produced three manuscripts [46,55,56]. Six studies were reported from Norway [46,48,50,52,55,56].…”

Section: Results Question #41: What Is the Relationship Between Seafomentioning

confidence: 99%

“…Seven were reports from three RCTs: the FINS-KIDS study produced three manuscripts [48,50,52] and the FINS-TEENS study produced three manuscripts [46,55,56]. Six studies were reported from Norway [46,48,50,52,55,56]. There were two each from Sweden [45,49], China [51,58], and Spain [53,54]; and there was one each from Korea [57], the U.S. [47] and the United Kingdom [14].…”

Section: Results Question #41: What Is the Relationship Between Seafomentioning

confidence: 99%

“…[14,[45][46][47][48][49][50][51][52][53][54][55][56][57][58]. Six RCT studies used FFQs to provide information on seafood consumption outside of an intervention involving fish meals at school [46,48,50,52,55,56,59]. Six studies provided neurocognitive outcomes for oily seafood separately [46,48,50,52,53,57].…”

Section: Results Question #41: What Is the Relationship Between Seafomentioning

confidence: 99%

“…Six RCT studies used FFQs to provide information on seafood consumption outside of an intervention involving fish meals at school [46,48,50,52,55,56,59]. Six studies provided neurocognitive outcomes for oily seafood separately [46,48,50,52,53,57]. Two studies reported that their FFQs prompted responses by asking about specific species of seafood [47,58].…”

Section: Results Question #41: What Is the Relationship Between Seafomentioning

confidence: 99%

“…Two studies suggested that oily seafood as compared to white seafood may be somewhat protective against risk of ADHD-related disorders, although the results might simply represent dietary preferences among children with and without ADHD-related disorders [53,57]. In three RCTs, children eating oily seafood meals had greater improvement on test scores as compared to meat meals [46,50,52] and in one of these, oily seafood meals were more beneficial than omega-3 supplements [46]. These studies did not compare oily seafood to white seafood, however.…”

Section: Relationships To Types Of Seafoodmentioning

confidence: 99%

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Relationships between seafood consumption during pregnancy and childhood and neurocognitive development: Two systematic reviews

Hibbeln

Spiller

Brenna

et al. 2019

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Abundant data are now available to evaluate relationships between seafood consumption in pregnancy and childhood and neurocognitive development. We conducted two systematic reviews utilizing methodologies detailed by the Dietary Guidelines for Americans Scientific Advisory Committee 2020-2025. After reviewing 44 publications on 106,237 mother-offspring pairs and 25,960 children, our technical expert committee developed two conclusion statements that included the following: "Moderate and consistent evidence indicates that consumption of a wide range of amounts and types of commercially available seafood during pregnancy is associated with improved neurocognitive development of offspring as compared to eating no seafood. Overall, benefits to neurocognitive development began at the lowest amounts of seafood consumed (∼4 oz/wk) and continued through the highest amounts, above 12 oz/wk, some range up to > 100 oz/wk.", "This evidence does not meet the criteria for "strong evidence" only due to a paucity of randomized controlled trials that may not be ethical or feasible to conduct for pregnancy" and "Moderate and consistent evidence indicates that consumption of > 4 oz/wk and likely > 12 oz/wk of seafood during childhood has beneficial associations with neurocognitive outcomes." No net adverse neurocognitive outcomes were reported among offspring at the highest ranges of seafood intakes despite associated increases in mercury exposures. Data are insufficient for conclusive statements regarding lactation, optimal amounts, categories or specific species characterized by mercury content and neurocognitive development; although there is some evidence that dark/oily seafood may be more beneficial. Research was conducted in healthy women and children and is generalizable to US populations. Assessment of seafood as a whole food integrates inherently integrates any adverse effects from neurotoxicants, if any, and benefits to neurocognition from omega-3 fats, as well as other nutrients critical to optimal neurological development. Understanding of the effects of seafood consumption on neurocognition can have significant public health implications. rich source of key nutrients that are biologically essential for optimal fetal and child neurodevelopment including iodine, vitamin B 12 , iron, vitamin D, zinc, manganese and highly unsaturated omega-3 and omega-6 fatty acids [1]. Women are more likely to the achieve optimal intakes of these nutrients when consuming seafood in pregnancy [2].

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Section: Results Question #41: What Is the Relationship Between Seafomentioning

confidence: 99%

Section: Results Question #41: What Is the Relationship Between Seafomentioning

confidence: 99%

Section: Results Question #41: What Is the Relationship Between Seafomentioning

confidence: 99%

Section: Results Question #41: What Is the Relationship Between Seafomentioning

confidence: 99%

Section: Relationships To Types Of Seafoodmentioning

confidence: 99%

See 3 more Smart Citations

Relationships between seafood consumption during pregnancy and childhood and neurocognitive development: Two systematic reviews

Hibbeln

Spiller

Brenna

et al. 2019

Prostaglandins, Leukotrienes and Essential Fatty Acids

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Health Risk of Infants Exposed to Lead and Mercury Through Breastfeeding

Lin

Chang

et al. 2022

Expo Health

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Donor milk from the human milk bank is important for vulnerable infants without their mothers’ own milk. Longitudinal changes in toxic metals in donor milk has not been reported. This study aimed to assess the effect of donors’ demographic characteristics, life habits and dietary habits on the concentration of metals in breastmilk donated to a human milk bank and to assess the health risk of lead (Pb) and mercury (Hg) exposure of donor mothers’ offspring through breastfeeding and the vulnerable recipients. A total of 228 samples, which were longitudinally donated to the human milk bank by 39 donors, were selected specifically to assess the levels of Pb, Hg, and MeHg. Donors’ offspring were also enrolled as mother-infant-dyads to monthly obtain the milk consumption and body weight. The results showed significant differences in the infant risk in exclusive breastfeeding months. The average Pb level of breast milk was 6.49 ± 5.23 µg/L (mean ± standard deviation), and the Hg level was 0.76 ± 0.98 µg/L. The sources of these toxins—residential districts, cleaning products, cosmetics, drinking water, viscera, eggs, seafood, and canned food—have a significant influence on the concentration of toxic metals in human milk. This study showed an unacceptable non-cancerous health risk (95th percentile hazard index, HI = 1.37 > 1) for Pb and Hg. In the future, the breast milk offered by the bank should be strictly monitored, especial for Pb, to ensure high-quality donor milk for vulnerable recipients but also donor mothers’ offspring who depend on it. Graphical Abstract

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