Fatty Infiltration of Respiratory Muscles in the Pickwickian Syndrome

Fadell, Edward J.; Richman, Anne Dunbar; Ward, Will W.; Hendon, James Robert

doi:10.1056/nejm196204262661704

Cited by 44 publications

(11 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, decreased skeletal muscle glycogen synthase activity in obese subjects may be associated with decreased isokinetic skeletal muscle endurance 10, 11, although it is not known if this phenomenon actually occurs in respiratory muscles. Further, fatty infiltration of respiratory and non-respiratory skeletal muscle in obese subjects has been well-documented 12-14, although its clinical significance related to muscle strength is unclear.…”

Section: Altered Resting Respiratory Physiology In Obesitymentioning

confidence: 99%

Altered Resting and Exercise Respiratory Physiology in Obesity

Sood¹

2009

Clinics in Chest Medicine

View full text Add to dashboard Cite

Synopsis Obesity, particularly severe obesity, affects both resting and exercise-related respiratory physiology. Severe obesity classically produces a restrictive ventilatory abnormality, characterized by reduced expiratory reserve volume. However, obstructive ventilatory abnormality may also be associated with abdominal obesity. Decreased peak work rates are usually seen among obese subjects in a setting of normal or decreased ventilatory reserve and normal cardiovascular response to exercise. Weight loss may reverse many adverse physiological consequences of severe obesity on the respiratory system.

show abstract

Section: Altered Resting Respiratory Physiology In Obesitymentioning

confidence: 99%

Altered Resting and Exercise Respiratory Physiology in Obesity

Sood¹

2009

Clinics in Chest Medicine

View full text Add to dashboard Cite

show abstract

“…Possible mechanisms for these reductions in lung volumes include: abnormal load compensation secondary to impaired respiratory neuromuscular coupling [86], both right and left-sided heart failure secondary to desaturation from obstructive or central apnoeas, hypopnoeas, or hypoventilation during sleep [87]; or fatty infiltration of the diaphragm [88]. This restriction is frequently improved substantially after effective treatment of sleep apnoea, or after weight loss of a magnitude which would not be expected to change lung volumes significantly but which is associated with significant improvements in ventilation during sleep.…”

Section: Thoracic Cage Abnormalitiesmentioning

confidence: 99%

Pathophysiology of changes in absolute lung volumes

Bancalari

Clausen

1998

Eur Respir J

View full text Add to dashboard Cite

Changes in absolute lung volumes are common in lung disease and result in significant impacts on gas exchange, respiratory muscle function, the sensation of dyspnoea, and limitations to maximal exercise. Though our knowledge regarding the magnitude and determinants of changes in lung volumes in health and disease has increased in the past 20 years, a number of important questions remain unanswered. Consideration of the limitations of specific methods for measuring lung volumes is essential when analysing published studies regarding absolute lung volumes in infants, children and adults. Though functional residual capacity is most commonly measured in children and adults with the subject awake and at rest, increasingly attention is being directed to making these measurements under clinically more relevant conditions (e.g. during exercise, sleep, anesthesia, or mechanical ventilation). The relationships between dynamic changes in functional residual capacity, flow limitation during tidal breaths, sensation of dyspnoea and exercise limitation are important to understand, and are the focus of current and future research. Improved understanding of these relationships may lead to improvements in therapy of patients with acute and chronic lung disease and are likely to be particularly important for evaluating the efficacy of and optimal patient selection for new modes of therapy, such as lung volume reduction surgery.

show abstract

“…[28][29][30][31] Therefore, an obesity was suspected to have an effect upon BHR. A study of European Community Respiratory Health Survey demonstrated that BHR increases with the body mass index (BMI) in men but not women.…”

Section: Discussionmentioning

confidence: 99%

Relationship between the Serum Leptin Concentration and Bronchial Hyperresponsiveness in Preschool Children

Mizoguchi¹,

Mochizuki²,

Muramatsu³

et al. 2008

Pediatric Asthma, Allergy & Immunology

View full text Add to dashboard Cite

The objective of this article was to investigate the relationship between serum leptin concentration and airway inflammation in preschool children with asthma, the individual serum leptin concentration, obesity index, and respiratory function, including bronchial hyperresponsiveness (BHR), were investigated. The relationship between the serum leptin concentration and the obesity index was determined in 103 healthy preschool children aged 6 as controls. For the BHR investigation, the serum leptin concentration in 57 preschool children aged 6 (33 with asthma and 24 wheezers) was determined. These children then underwent lung function tests using methacholine inhalation challenge by the oscillation method. The BHR was also measured in 15 of the 103 controls subjects. In the control group, serum leptin concentration was significantly correlated to the obesity index. There was no statistical difference in both serum leptin concentration and the obesity index among the asthma patients, the wheezers and the control group. Although there was no significant association between serum leptin concentration and lung function parameters (FVC, FEV 1 , and VЈ50), a significant association was observed between the serum leptin concentration and BHR (p Ͻ 0.038), and between obesity index and BHR (p ‫؍‬ 0.015). The serum IL-6 concentration was not related with the serum leptin concentration and BHR. These results suggest that serum leptin has no effect on lung functional parameters but does affect the BHR, and that the relationship between leptin and airway inflammation may contribute to the severity of childhood asthma at 6 years of age. (Pediatr Asthma Allergy Immunol 2008; XX[X]; 000-000.)

show abstract

Fatty Infiltration of Respiratory Muscles in the Pickwickian Syndrome

Cited by 44 publications

References 10 publications

Altered Resting and Exercise Respiratory Physiology in Obesity

Altered Resting and Exercise Respiratory Physiology in Obesity

Pathophysiology of changes in absolute lung volumes

Relationship between the Serum Leptin Concentration and Bronchial Hyperresponsiveness in Preschool Children

Contact Info

Product

Resources

About