Fatty liver, carotid disease and gallstones: A study of age-related associations

Lonardo, Amedeo; Lombardini, S.; Scaglioni, F.; Ballestri, Stefano; Verrone, A; Bertolotti, Marco; Carulli, Lucia; Ganazzi, Dorval; Carulli, Nicola; Loria, Paola

doi:10.3748/wjg.v12.i36.5826

Cited by 50 publications

(47 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Firstly, among the studies used for analyzing the prevalence of GD in NAFLD, two studies were from North America (21,34), five studies were from Europe (26,(30)(31)(32)(33), and three studies were from Asia (19,27,28). Although the study distribution was unbalanced, the sample size from each continent was relatively balanced.…”

Section: Discussionmentioning

confidence: 99%

“…Liver biopsy was used to define NAFLD in three studies (26)(27)(28), ultrasonography in seven studies (19)(20)(21)(29)(30)(31)(32), biochemistry in one study (33), and all three methods were used in one study (34). Study origins included two from North America (USA) (21,34), five from Europe (Slovakia, Italy, and Hungary) (26,(30)(31)(32)(33), and five from Asia (China, Turkey, and Korea) (20,(27)(28)(29).…”

Section: Study and Patient Characteristicsmentioning

confidence: 99%

“…Ten studies (19,21,(26)(27)(28)(30)(31)(32)(33)(34) that involved a total of 39,602 patients discussed GD prevalence in NAFLD patients with a range of 8%-47%. The pooled result was 17% (95% CI: 0.12-0.23), as shown in Figure 2.…”

Section: Gd Prevalence In Nafld Patientsmentioning

confidence: 99%

See 2 more Smart Citations

Promotional effect of nonalcoholic fatty liver disease on Gallstone disease: A systematic review and meta-analysis

Shen¹,

Gong²,

Wang³

et al. 2020

Turk J Gastroenterol

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: Study and Patient Characteristicsmentioning

confidence: 99%

See 1 more Smart Citation

Promotional effect of nonalcoholic fatty liver disease on Gallstone disease: A systematic review and meta-analysis

Shen¹,

Gong²,

Wang³

et al. 2020

Turk J Gastroenterol

View full text Add to dashboard Cite

“…Two Korean studies reported an independent association between baPWV and NAFLD in general subjects including the elderly (Kim et al, 2012;Lee et al, 2012). Considering that the incidence of NAFLD decreases with age (Lonardo et al, 2006) and increases with BMI (Vernon et al, 2011), general subjects may not be representative of the young and middle-aged population which are non-obese, non-hypertensive, and non-diabetic, and thus may not be useful for suggesting the direct association between NAFLD and arterial stiffness. For these reasons, clarifying the association between NAFLD and arterial stiffness in non-obese, nonhypertensive, and non-diabetic young and middleaged subjects may have significant clinical implications for the prevention and diagnosis of early arterial stiffness as well as early atherosclerotic change by screening NAFLD.…”

Section: Introductionmentioning

confidence: 99%

Association between non-alcoholic fatty liver disease and arterial stiffness in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population

Zhao

Song

et al. 2014

J. Zhejiang Univ. Sci. B

View full text Add to dashboard Cite

Background and objective: Non-alcoholic fatty liver disease (NAFLD) is associated with arterial stiffness in the general population. Age, obesity, hypertension, and diabetics are risk factors for arterial stiffness. In this study, we aimed to investigate the association between NAFLD and arterial stiffness as measured by brachial-ankle pulse wave velocity (baPWV) in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population. Methods: A cross-sectional study with 1296 non-obese, non-hypertensive, and non-diabetic young and middle-aged (20-65 years) subjects undergoing routine medical check-ups in the International Health Care Center of the Second Affiliated Hospital of School of Medicine of Zhejiang University was carried out. Fatty liver was diagnosed by ultrasonography, and baPWV was measured using an automatic waveform analyzer. The subjects were classified into two groups according to the presence of NAFLD, and divided into a further two groups according to their baPWV. Results: The overall incidence of NAFLD was 19.0%, and NAFLD patients had a significantly higher level of baPWV than the controls ((1321±158) cm/s vs. (1244±154) cm/s; P<0.001). The incidence of NAFLD was clearly higher in the increased baPWV group than in the normal baPWV group (29.3% vs. 16.9%; P<0.001), and the incidence increased in line with the increase of baPWV quartiles in the normal range as well as with the severity of arterial stiffness (both P for trend <0.001). Multiple linear logistic regression analysis showed that the presence of NAFLD was positively and independently associated with baPWV. Conclusions: Our results suggest that the presence of NAFLD is associated with arterial stiffness as measured by baPWV in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population.

show abstract

“…On both conditions were quite common among patients with known metabolic risk factors (41% had NAFLD, 34% had gallstone disease). But several studies aimed to prove association between gallstones and NAFLD have shown contradictory results [12][13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Non-Alcoholic Fatty Liver Disease as a Risk Factor for Acute Pancreatitis: A Case Control Study

M¹

2015

Emerg Med (Los Angel)

View full text Add to dashboard Cite

Objective: Visceral obesity is an etiological factor and a marker of poor prognosis in acute pancreatitis (AP). Non-Alcoholic Fatty Liver Disease (NAFLD), a marker for visceral obesity, has also been recognized to have a stronger correlation to poor outcomes. With this study, we aim to assess the role of NAFLD as an etiologic factor in patients with AP. Materials and Methods:In this retrospective electronic medical record (EMR) based case control study of 530 non-alcoholic adults were classified into cases with acute pancreatitis and controls without pancreatitis. Further subgroup was classified based on gallstone formation as an etiology of pancreatitis. Data was evaluated with McNemar's Test. Results:Results showed that patients with AP due to Gallstones had a higher incidence of NAFLD as seen on abdominal imaging [OR=1.688, p=0.0235 (CI: 1.070-2.701)], but Patients with AP due to unclear etiology did not have statistically significant higher rates of NAFLD [OR: 1.400, CI: 0.688 -2.919]. Patients with AP due to all etiologies combined had higher incidence of NAFLD [(OR: 1.596, CI: 1.094-2.349, P-value 0.0145)]. Conclusion:We conclude from this study shows that NAFLD may be an independent risk factor for development of acute pancreatitis. It is also possible that NAFLD may have pathophysiologic interplay with formation of gallstones that is a known risk factor for acute pancreatitis.

show abstract

Fatty liver, carotid disease and gallstones: A study of age-related associations

Abstract: Cardiovascular risk in patients with FL and NAFLD needs to be assessed as a function of age and body weight.

Cited by 50 publications

References 44 publications

Promotional effect of nonalcoholic fatty liver disease on Gallstone disease: A systematic review and meta-analysis

Promotional effect of nonalcoholic fatty liver disease on Gallstone disease: A systematic review and meta-analysis

Association between non-alcoholic fatty liver disease and arterial stiffness in the non-obese, non-hypertensive, and non-diabetic young and middle-aged Chinese population

Non-Alcoholic Fatty Liver Disease as a Risk Factor for Acute Pancreatitis: A Case Control Study

Contact Info

Product

Resources

About