Fatty liver disease as a predictor of local recurrence following resection of colorectal liver metastases

Abstract

Hepatic steatosis was an independent predictor of local hepatic recurrence following resection with curative intent of colorectal liver metastases.

Effect of Non-Alcoholic Liver Disease on Recurrence Rate and Liver Regeneration after Liver Resection for Colorectal Liver Metastases

“…We also examined the effect on tumour recurrence of each nafld histologic feature separately and looked into the effect of micro-and macro-steatosis. Hamady et al 69 concluded that liver steatosis is an independent predictor for disease recurrence. On the other hand, Murono et al 70 found that crc-lm occurs less frequently in fatty livers after resection, suggesting that steatosis might provide an unfavourable environment for metastasis in liver.…”

A novel technique for hepatic vein reconstruction during hepatectomy

“…Parenchymal abnormalities that occur during liver regeneration independently worsen oncological outcomes [4–6]. Thus, major hepatectomies with intense post-operative regeneration or segmentectomies that leave parenchyma without adequate venous drainage may not be the best treatment for hepatic malignancies.…”

Digital histology quantification of intra-hepatic fat in patients undergoing liver resection

“…[1][2][3] Moderate to severe steatosis (triglyceride content >33% 4 ) and steatohepatitis (steatosis with hepatocyte ballooning, lobular inflammation and fibrosis 4 ) are associated with increased post-operative morbidity (two-fold increase) and peri-operative mortality (2.8-to 10-fold increase). 5,6 Retrospective studies have shown excess body mass index (BMI), diabetes and pre-operative chemotherapy are associated with steatosis and/or steatohepatitis in the resection specimen.…”