2019
DOI: 10.1016/j.cmet.2019.08.018
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Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae

Abstract: Highlights d High-alcohol-producing strains of Klebsiella pneumoniae exist in humans d HiAlc Kpn is associated with NAFLD in a human cohort d Transplant of HiAlc Kpn into mice causes NAFLD d Feeding mice glucose led to detectable blood alcohol, suggesting a biomarker for NAFLD

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Cited by 355 publications
(310 citation statements)
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“…In fact, the authors found that high-alcohol-producing Klebsiella pneumoniae was associated with up to 60% of individuals with NAFLD in a Chinese cohort [53].…”
Section: Probiotics/prebioticsmentioning
confidence: 99%
“…In fact, the authors found that high-alcohol-producing Klebsiella pneumoniae was associated with up to 60% of individuals with NAFLD in a Chinese cohort [53].…”
Section: Probiotics/prebioticsmentioning
confidence: 99%
“…Microbial‐derived PAMPs are capable of inciting an immune reaction and inflammation in the liver. Recently, the presence of a strain of bacterium ( Klebsiella pneumoniae ) that produces high levels of endogenous alcohol was associated with NAFLD in a human cohort . Bile acids are synthesized and secreted by hepatocytes and are involved in the absorption of dietary lipids.…”
Section: Intercellular and Interorgan Crosstalkmentioning
confidence: 99%
“…Recently, the presence of a strain of bacterium (Klebsiella pneumoniae) that produces high levels of endogenous alcohol was associated with NAFLD in a human cohort. (96) Bile acids are synthesized and secreted by hepatocytes and are involved in the absorption of dietary lipids. They are transported back to the liver by enterohepatic circulation and act on the nuclear farnesoid X receptor (FXR), which is also expressed on hepatocytes, to influence glucose (97) and lipid metabolism.…”
Section: Gut-liver Axismentioning
confidence: 99%
“…σ-ADH is primarily found in the gastric mucosa, though its expression is absent in approximately one-third of the Asians population [44]. Microorganisms can produce alcohol [45,46] and express numerous forms of alcohol dehydrogenase, which can contribute to the formation of acetaldehyde in the gastrointestinal tract, or wherever microbial overgrowth occurs [47,48].…”
Section: Alcohol Dehydrogenase (Adh)mentioning
confidence: 99%