Fatty Liver Disease: Predictors of Nonalcoholic Steatohepatitis and Gallbladder Disease in Morbid Obesity

Liew, Phui Ly; Lee, Wei Jei; Wang, Weu; Lee, Yi Chih; Chen, Wei Yu; Fang, Chia Lang; Huang, Ming Te

doi:10.1007/s11695-007-9355-0

Cited by 42 publications

(32 citation statements)

References 33 publications

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“…Harrison et al [24] and Yatsuji et al [25] said that advanced age was related to advanced fibrosis. Singh et al [26] and Liew et al [27] found that older females were identified as independent predictors of fibrotic severity. Ong et al [12] , Helling et al [28] and Arun et al [29] stated that male gender was associated with NASH.…”

Section: Discussionmentioning

confidence: 99%

“…Assy et al [45] defined hypertriglyceridemia and diabetes as the only risk factors that increase the risk of fatty infiltration in hyperlipidemic patients. Liew et al [27] featured that serum cholesterol and low-density lipoprotein cholesterol levels were risk factors associated with gallbladder disease and fatty liver disease. Rodríguez-Hernández et al [33] said that diabetes and ALT correlated with histological hepatic changes.…”

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confidence: 99%

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Noninvasive predictors for liver fibrosis in patients with nonalcoholic steatohepatitis

Uslusoy¹

2011

WJH

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AIM:To evaluate certain anthropometric, clinical and laboratory features indicating liver fibrosis in nonalcoholic steatohepatitis and to establish the noninvasive markers for liver fibrosis. METHODS:Eighty-one patients (40 male, 41 female) who were diagnosed with fatty liver by ultrasonographic examination and fulfilled the inclusion criteria participated in the study. Anamnesis, anthropometric, clinical and laboratory features of all cases were recorded and then liver biopsy was performed after obtaining patient consent. Steatosis, necroinflammation and liver fibrosis were examined according to age ≥ 45, gender, body mass index, central obesity, aspartate aminotransferase (AST)/alanine aminotransferase (ALT) > 1, γ-glutamyltransferase (GGT)/ALT > 1, platelet count, insulin, c-peptide levels and the presence of hypertension, diabetes, hypertriglyceridemia and insulin resistance. RESULTS:Eighty-one patients with non-alcoholic steatohepatitis (NASH) enrolled in the study. 69 of 81 patients were diagnosed with NASH, 11 were diagnosed with simple fatty liver and 1 was diagnosed with cirrhosis. AST/ALT > 1, GGT/ALT > 11, high serum ferritin and fasting insulin levels, the presence of diabetes, hypertension, hypertriglyceridemia and insulin resistance seemed to enhance the severity of steatosis, necroinflammation and fibrosis but these results were not statistically significant. CONCLUSION:Liver steatosis and fibrosis can occur in individuals with normal weight. There was no significant concordance between severity of liver histology and the presence of predictors for liver fibrosis including metabolic risk factors.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Noninvasive predictors for liver fibrosis in patients with nonalcoholic steatohepatitis

Uslusoy¹

2011

WJH

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“…The fact the patient has an enzymatically and genetically proven GSDIa and presented with adenomatosis and HCC in adult age, should prompt liver specialists and oncologists to look for GSDIa in patients presenting with adenomatosis and/or HCC, even when adult. The presence of hepatocytes with swollen and pale cytoplasm is a well-known feature of GSD [11] Although glycogenated nuclei in the periportal area are known to represent a disturbance of glycogen metabolism, as is seen in, e.g., NASH [12], they have hitherto not been reported as a typical feature of GSD. Therefore, it is possible that they are related to the atypical clinical presentation of this patient.…”

Section: Discussionmentioning

confidence: 99%

An adult male patient with multiple adenomas and a hepatocellular carcinoma: Mild Glycogen Storage Disease type Ia

Cassiman

Libbrecht

Verslype³

et al. 2010

Journal of Hepatology

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The development of hepatocellular adenomas and - more rarely - carcinoma in the liver of patients with Glycogen Storage Disease type Ia (GSDIa) is a well-known complication of the disease. The pathophysiology of adenoma and carcinoma development in these patients is, however, hitherto largely unknown and is thought to be related to the metabolic control of the patient and/or the type of mutations in the G6PC gene. We report here on a very illustrative case of adenoma and carcinoma formation in a previously undiagnosed 42 year old male GSDIa patient (enzymatically and genetically proven). He had two episodes of mild hypoglycaemia in childhood, never required formal treatment, showed normal growth, and only mild lactate increases after prolonged starvation. He was a long-distance runner for most of his adult life, without the need for more than normal carbohydrate intake before/during exertion. To gain a better view on the type of adenoma formed in this patient, molecular studies were performed. We show here that in this patient with mild GSDIa without recurrent hypoglycaemic episodes, adenoma and carcinoma formation still occurred and that malignant transformation of adenoma here is associated with CTNNB1 mutations and a typical mRNA profile of a beta-catenin activated lesion.

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“…The pathogenesis of steatohepatitis is multifactorial. Insulin resistance, higher serum levels of cholesterol and LDL cholesterol may be important factors in the accumulation of hepatocellular fat, whereas excess intracellular fatty acids, oxidant stress, adenosine triphosphate (ATP) depletion, and mitochondrial dysfunction may be important causes of hepatocellular injury in the steatotic liver [22,23].…”

Section: Discussionmentioning

confidence: 99%

Sleeve Gastrectomy Relieves Steatohepatitis in High-Fat-Diet-Induced Obese Rats

Wang

Liu²

2008

OBES SURG

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Fatty Liver Disease: Predictors of Nonalcoholic Steatohepatitis and Gallbladder Disease in Morbid Obesity

Cited by 42 publications

References 33 publications

Noninvasive predictors for liver fibrosis in patients with nonalcoholic steatohepatitis

Noninvasive predictors for liver fibrosis in patients with nonalcoholic steatohepatitis

An adult male patient with multiple adenomas and a hepatocellular carcinoma: Mild Glycogen Storage Disease type Ia

Sleeve Gastrectomy Relieves Steatohepatitis in High-Fat-Diet-Induced Obese Rats

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