“…Afterwards, we use our model within an inverse modeling framework of iTOUGH2-PEST (Finsterle and Zhang, 2011), which includes parameter estimation, sensitivity and uncertainty analyses and apply it to all three injection wells On one hand, the TOUGH-FLAC simulator (Rutqvist, 2011) couples the TOUGH2 simulator for fluid flow in porous media with the FLAC3D simulator for geomechanics and deformation (Itasca, 2009). The applications of TOUGH-FLAC cover geothermal (e.g., Jeanne et al, 2015;Rinaldi et al, 2015a), nuclear waste disposal (e.g., , compressed air storage systems , shale gas 2015), as well as geologic carbon sequestration (Rutqvist et al, 2008; and related induced seismicity (Cappa and Rutqvist, 2011;Rinaldi et al, 2014aRinaldi et al, , 2014bRinaldi et al, , 2015bRutqvist et al, , 2016Urpi et al, 2016). On the other hand, iTOUGH2 (Finsterle, 2004;2007;Finsterle et al, 2014) has been largely used for sensitivity analysis and parameter estimation for several hydrogeological application (e.g., Doetsch et al, 2013;Finsterle et al, 2013;Poskas et al, 2014;Wainwright et al, 2013;Yuan et al, 2015).…”