This chapter explores the convergence of sustainability, intelligent methods, and smart grids as a solution to the escalating energy demands and environmental concerns of the 21st century. It investigates how smart grids, empowered by machine learning, artificial intelligence, and other advanced techniques, can create a more efficient and environmentally friendly energy ecosystem. Key applications in load forecasting, demand management, renewable integration, and grid optimization are examined. The chapter acknowledges challenges like resource intensity and data privacy, advocating for robust regulations and responsible development to ensure equitable access to smart grid benefits. Ultimately, it presents a comprehensive analysis of this synergy, aiming to equip readers with the knowledge to navigate the complexities of the energy landscape and build a sustainable energy future.