Abstract. The paper focuses on fault tolerant attitude stabilization control for hypersonic vehicles (HSV) in the presence of loss of actuator effectiveness, input saturation and modeling uncertainties simultaneously. Firstly, an adaptive fuzzy observer was constructed to estimate the actuator faults and lumped disturbance. Then, the auxiliary system is introduced to compensate for saturation effect with the loss fault. Accordingly, a fault tolerant control law based on backstepping method is reconfigured under the reconstructed fault information. Finally based on the Lyapunov theory analysis, tracking error converges to arbitrary neighborhood around zero. It is shown that the proposed controller guarantees all the signals in the closed-loop system to be uniformly ultimately bounded. Finally, simulation results are given to illustrate the effectiveness of the proposed controller.