SUMMARYThis special issue contains papers applying a broad range of set-membership techniques to fault detection and isolation and fault tolerant control. Following the successful organization of special sessions on related topics in several international conferences as IFAC Safeprocess (2012), NOLCOS (2013) and IEEE CDC (2012, 2013), this special issue gives an overview on recent advances of set-membership-based fault detection and isolation and fault tolerant control. Special attention is paid on covering a significant range of application targets for the recent theoretical developments in this active † field.