Although resilience is already an established field in system science and many methodologies and approaches are available to deal with it, the unprecedented scales of computing, of the massive data to be managed, new network technologies, and drastically new forms of massive scale applications bring new challenges that need to be addressed. This paper reviews the challenges and approaches of resilience in ultrascale computing systems from multiple perspectives involving and addressing the resilience aspects of hardware-software co-design for ultrascale systems, resilience against (security) attacks, new approaches and methodologies to resilience in ultrascale systems, applications and case studies.