Favipiravir in early symptomatic COVID-19, a randomised placebo-controlled trial

Favipiravir does not improve viral clearance in mild to moderate COVID-19 – A systematic review and meta-analysis of randomized controlled trials

“…Five studies provided evidence for patients with mild symptoms and three studies for patients with moderate symptoms [ 12 , 13 , 16 , 23 , 27 , 28 ]. There studies did not provide a subgroup analysis by severity [ 19 , 25 , 29 ].…”

“…17 studies reported at least one side effect that can be analysed in the meta-analysis [ 3 , 10 , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [23] , [24] , [25] , [26] , 28 , 29 ] ( Table S1 ). The risks of developing low haemoglobin, hyperglycemia, elevated ALT and AST, high bilirubin, elevated creatine phosphokinase, high triglycerides, and leukopenia were comparable between the favipiravir and comparator groups ( Fig.…”

Prevalence and clinical impact of mono- and co-infections with endemic coronaviruses 229E, OC43, NL63, and HKU-1 during the COVID-19 pandemic

“…Assessment of the patient's condition was made according to a category scale: 1 –not hospitalised with the resumption of normal activity; 2 - not hospitalised, but cannot resume normal activities; 3 - hospitalised, without need for additional oxygen; 4 - hospitalised, requiring additional oxygen; 5 - hospitalised requiring high-flow nasal oxygen therapy, non-invasive mechanical ventilation, or both; 6 - hospitalised requiring extracorporeal membrane oxygenation, invasive mechanical ventilation, or both; 7 – death [ 28 ].…”

Efficacy and Safety of Favipiravir for the Treatment of COVID-19 Outpatients: A Systematic Review and Meta-analysis of Randomized Controlled Trials

“…A total of 9 studies were included in our meta-analysis. [8][9][10][11][12][13][14][15][16] The detailed selection process is shown in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses flowchart (see Figure 1, Supplemental Digital Content, http://links.lww.com/AJT/A139). One study included both inpatients and outpatients 10 while the rest of the studies included outpatients exclusively.…”