Favism: A Case Report

Diegues, Andreia; Simões, Pedro; Ceriz, Tiago; Lopes, Ana Rita; Tomé, Elisa

doi:10.7759/cureus.23269

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…However, it complicates the administration of antimalarial drugs with oxidative properties like primaquine or tafenoquine, which can lead to a hemolytic crisis. [ 5 , 41 ] Diagnosis is made by testing the enzymatic activity of G6PDin RBCs. Results below 80% of the normal’s lower limit must be considered deficient.…”

Section: Anemiamentioning

confidence: 99%

Blood cytopenias as manifestations of inherited metabolic diseases: a narrative review

Moutapam-Ngamby—Adriaansen,

Maillot,

Labarthe

et al. 2024

Orphanet J Rare Dis

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Inherited Metabolic Diseases (IMD) encompass a diverse group of rare genetic conditions that, despite their individual rarity, collectively affect a substantial proportion, estimated at as much as 1 in 784 live births. Among their wide-ranging clinical manifestations, cytopenia stands out as a prominent feature. Consequently, IMD should be considered a potential diagnosis when evaluating patients presenting with cytopenia. However, it is essential to note that the existing scientific literature pertaining to the link between IMD and cytopenia is limited, primarily comprising case reports and case series. This paucity of data may contribute to the inadequate recognition of the association between IMD and cytopenia, potentially leading to underdiagnosis. In this review, we synthesize our findings from a literature analysis along with our clinical expertise to offer a comprehensive insight into the clinical presentation of IMD cases associated with cytopenia. Furthermore, we introduce a structured diagnostic approach underpinned by decision-making algorithms, with the aim of enhancing the early identification and management of IMD-related cytopenia.

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Section: Anemiamentioning

confidence: 99%

Blood cytopenias as manifestations of inherited metabolic diseases: a narrative review

Moutapam-Ngamby—Adriaansen,

Maillot,

Labarthe

et al. 2024

Orphanet J Rare Dis

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“…The severity of hemolytic anemia and hemolitic episodes varies from patient to patient thus favism's diagnosis can be challenging. According to the case report from 2022, G6PD-deficient individuals can be triggered not only by fava beans, but also other substances such as a wide range of drugs, industrial chemicals, and alcohol (Diegues, Simoes, Ceriz, Lopes, and Tome, 2022).…”

Section: Threats Arising From a Plant-based Dietmentioning

confidence: 99%

Potential Benefits and Threads Arising from a Plant-Based Diet

Gąsiewska¹,

Jancza-Smuga²

2022

Engineering Sciences And Technologies

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A plant-based diet is a type of diet gaining more and more popularity. It is a elimination diet excluding all animal products and by-products. There are many reasons for switching from a traditional diet to a plant-based diet. This paper focuses on the four most prevalent reasons for switching diet: economical, health-related, ethical and ecological. The potential benefits and threats of a plant-based diet are also presented.

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Revealing the secrets of Blue Zones

Ulusu

2024

Front. Pharmacol.

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Aging is influenced by cellular senescence mechanisms that are associated with oxidative stress. Oxidative stress is the imbalance between antioxidants and free radicals. This imbalance affects enzyme activities and causes mitochondrial dysfunction. It also slows down cellular energy production and disrupts cellular homeostasis. Additionally, oxidative stress stimulates inflammation, increases the number of point mutations, and alters intercellular communication. It can lead to epigenetic alterations, genomic instability, telomere attrition, and loss of proteostasis. Ultimately, these factors contribute to aging and the development of chronic diseases. Glucose-6-phosphate dehydrogenase (G6PD) is an antioxidant enzyme that protects cells from oxidative and nitrosative damage. It helps restore redox balance, preserve macromolecule function, and rescue cells from cellular senescence, autophagy, and stress-induced apoptosis. G6PD is considered an anti-senescence enzyme. The World Health Organization classifies G6PD variants into five groups based on the enzyme’s residual activity. The first four classes are categorized according to the degree of G6PD deficiency, while the fifth class includes variants with enzyme activities greater than normal. Increased G6PD activity does not exhibit clinical manifestations. Consequently, the full spectrum of mutations and the prevalence of increased G6PD activity in the population remain unknown. The world’s oldest and healthiest people live in Blue Zones. These comprise isolated populations, and there may be a geographic prevalence of high-activity G6PD variants that protect against oxidative stress-induced senescence. To uncover the secret of centenarians’ longevity, additional research is needed to determine whether the hidden factor is the increased activity of the G6PD enzyme.

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Favism: A Case Report

Cited by 4 publications

References 7 publications

Blood cytopenias as manifestations of inherited metabolic diseases: a narrative review

Blood cytopenias as manifestations of inherited metabolic diseases: a narrative review

Potential Benefits and Threads Arising from a Plant-Based Diet

Revealing the secrets of Blue Zones

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