Favorable Effects of Concord Grape Juice on Endothelial Function and Arterial Stiffness in Healthy Smokers

Siasos, Gerasimos; Tousoulis, Dimitris; Kokkou, Eleni; Oikonomou, Evangelos; Kollia, Maria; Verveniotis, Aleksis; Gouliopoulos, Nikolaos; Zisimos, Konstantinos; Plastiras, Aris; Maniatis, Konstantinos; Stefanadis, Christodoulos

doi:10.1093/ajh/hpt176

Cited by 76 publications

(69 citation statements)

References 35 publications

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“…Dohadwala et al [44] demonstrated that concentrated cranberry juice (480 ml/ d) significantly improved carotid-femoral PWV after 6 weeks of supplementation in patients with CAD. This is supported by another study in apparently healthy smokers, which showed a significant improvement in PWV after only 2 weeks of supplementation with polyphenols-rich Concord grape juice [39] compared with low polyphenol-rich juice. This intervention also attenuated a post-cigarette deterioration in PWV at 7 days and 2 weeks.…”

Section: Fruit and Vegetables And Vascular Functionsupporting

confidence: 56%

“…Conversely, another study showed no effect on FMD after 7 days of supplementation with tomato puree (70 g/d) in postmenopausal, healthy women compared with placebo [37]. Fruit and vegetable supplement capsules have been shown to attenuate the FMD reduction in response to a high fat meal compared with placebo capsules [38] while a recent study demonstrated polyphenols-rich juice from Concord grapes significantly improved FMD compared with polyphenols-poor juice and prevented a postcigarette reduction in FMD after only 7 days, suggesting polyphenols are important in determining endothelial function [39]. Encapsulated grape solids (6Â 500 mg/d for two weeks) had no effect on FMD response to a high fat meal [40].…”

Section: Fruit and Vegetables And Endothelial Vasodilator Functionmentioning

confidence: 99%

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A systematic review of vascular and endothelial function: Effects of fruit, vegetable and potassium intake

Blanch

Clifton

Keogh

2015

Nutrition, Metabolism and Cardiovascular Diseases

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Section: Fruit and Vegetables And Vascular Functionsupporting

confidence: 56%

Section: Fruit and Vegetables And Endothelial Vasodilator Functionmentioning

confidence: 99%

A systematic review of vascular and endothelial function: Effects of fruit, vegetable and potassium intake

Blanch

Clifton

Keogh

2015

Nutrition, Metabolism and Cardiovascular Diseases

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“…It was suggested that the oriental plum fruit juice concentrate could exert a significant cardiovascular protective effect [89]. Moreover, endothelial function and arterial tree vascular elastic properties could be improved by consuming Concord grape juice [90]. …”

Section: Mechanisms Of Action Of Juice On Cardiovascular Diseasesmentioning

confidence: 99%

Effects and Mechanisms of Fruit and Vegetable Juices on Cardiovascular Diseases

Zheng

Zhou

et al. 2017

IJMS

137

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Many studies have indicated that consumption of vegetables and fruits are positively related to lower incidence of several chronic noncommunicable diseases. Although composition of fruit and vegetable juices is different from that of the edible portion of fruits and vegetables, they contain polyphenols and vitamins from fruits and vegetables. Drinking vegetable and fruit juices is very popular in many countries, and also an efficient way to improve consumption of fruits and vegetables. The studies showed that fruit and vegetable juices affect cardiovascular risk factors, such as lowering blood pressure and improving blood lipid profiles. The main mechanisms of action included antioxidant effects, improvement of the aspects of the cardiovascular system, inhibition of platelet aggregation, anti-inflammatory effects, and prevention of hyperhomocysteinemia. Drinking juices might be a potential way to improve cardiovascular health, especially mixtures of juices because they contain a variety of polyphenols, vitamins, and minerals from different fruits and vegetables. This review summarizes recent studies on the effects of fruit and vegetable juices on indicators of cardiovascular disease, and special attention is paid to the mechanisms of action.

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“…Despite promising initial results, however, alagebrium has not been studied in phase III trials, perhaps related to a number of negative results in other therapeutic areas [99][100][101][102][103]. A number of nutritional supplements such as flavonoids [104,105], isoflavone [106], omega-3 [106] and tetrahydrobiopterin [107,108] acting via an antioxidant effect and/or improvement of NO bioavailability have also been shown to improve arterial stiffness. However, these studies have similar limitations as discussed above [106].…”

Section: Origins Of Arterial Stiffness and Nurture Versus Nature?mentioning

confidence: 99%

Future Treatment of Hypertension: Shifting the Focus from Blood Pressure Lowering to Arterial Stiffness Modulation?

Fok

Cruickshank

2015

Curr Hypertens Rep

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Isolated systolic hypertension is the commonest form of hypertension from middle age onwards. Achieving target systolic blood pressure (BP) control remains difficult in everyday clinical practice and even under clinical trial conditions. Most antihypertensive medicines were designed to lower peripheral vascular resistance, which was considered the haemodynamic determinant of hypertension; most are effective in reducing steady but not pulsatile components of BP. Arterial stiffness, defined via aortic length-specific pulse wave velocity (PWV), is thought to be an important determinant of pulse pressure widening through its effects on the timing and amplitude of pressure wave reflection, and/or the aorta's Windkessel function, or its excess 'reservoir' pressure. Whereas pulse pressure is neither an independent nor consistent cardiovascular risk factor, particularly below the age of about 60 years, PWV has become the most powerful predictor of cardiovascular outcomes including mortality, independent of systolic, pulse, mean or other BP components. PWV is therefore a more direct target for treatment. This review addresses the potential therapeutic options for targeting arterial stiffness and the role of pulse pressure.

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Favorable Effects of Concord Grape Juice on Endothelial Function and Arterial Stiffness in Healthy Smokers

Abstract: CGJ consumption improved endothelial function and vascular elastic properties of the arterial tree in healthy smokers and attenuated acute smoking-induced impairment of arterial wall properties.

Cited by 76 publications

References 35 publications

A systematic review of vascular and endothelial function: Effects of fruit, vegetable and potassium intake

A systematic review of vascular and endothelial function: Effects of fruit, vegetable and potassium intake

Effects and Mechanisms of Fruit and Vegetable Juices on Cardiovascular Diseases

Future Treatment of Hypertension: Shifting the Focus from Blood Pressure Lowering to Arterial Stiffness Modulation?

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