Background: The incidence rate of lip and oral cancer is increasing in recent years, the prognosis of which is associated with a country’s socioeconomic status. The mortality-to-incidence ratio (MIR) is a reasonable indicator of disparities in cancer screening and treatment. We aim to understand the association between economic status and cancer prognosis.Methods: Data were obtained from the Global Cancer Observatory (GLOBOCAN) and the World Health Organization (WHO). The MIR was applied to evaluate the correlation to healthcare expenditures and the human development index (HDI) disparities via Spearman's rank correlation coefficient.Results: The results showed that Asia has the most cases and deaths. The association of the HDI, current health expenditure (CHE), and ratio of CHE to the percentage of gross domestic product (CHE/GDP) to the crude rate (CR) of incidence show significant results (p<0.001, p=0.005, and p<0.001, respectively). However, their association with the mortality rate (p=0.303, p=0.997, and p=0.101) is not significant. In the correlation of the MIRs, the results revealed a significant association with the HDI, CHE, and CHE/GDP with the MIR (p<0.001, p<0.001, and p<0.001, respectively).Conclusion: Countries with a higher HDI, more CHE per capita, and higher CHE/GDP tend to have a lower MIR, which indicates a favorable clinical outcome.