Favorable outcome in a case of Mycoplasma pneumoniae-associated crescentic glomerulonephritis

Adra, A; Vigué, M.G.; Vale, Fabienne Dalla; Ichay, L.; Raynaud, P; Mariani, A; Morin, Denis

doi:10.1007/s00467-010-1491-4

Cited by 11 publications

(6 citation statements)

References 14 publications

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“…Autoimmune reactions have been suggested to be responsible for many of these manifestations. In particular, M. pneumoniae -associated nephritis has been reported in few patients, with various pathological findings, including membranoproliferative GN, minimal change disease, endo-and extracapillary GN, and even immunoglobulin A nephropathy [5][6][7] . On the other hand, hemolytic anemia is recognized as a rare but severe complication of Mycoplasma infection.…”

Section: Discussionmentioning

confidence: 99%

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Acute Kidney Injury and Hemolytic Anemia Secondary to Mycoplasma pneumoniae Infection

Carrara

Abbate

Sabadini³

2017

Nephron

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Glomerulonephritis as well as kidney injury secondary to fulminant intravascular hemolysis are rare extrapulmonary manifestations of Mycoplasma pneumoniae infection. We describe a 50-year-old female diagnosed with M. pneumoniae infection-associated hemolytic anemia, characterized by negative cold agglutinin tests but with laboratory evidence of complement alternative pathway activation. The patient presented both with anemia and severe kidney failure and she was treated with steroids and red blood cell transfusions along with plasmapheresis. She also received a short course of antibiotics. Renal biopsy showed combined features of resolving postinfectious glomerulonephritis and hemolysis-associated extensive acute tubular injury characterized by renal hemosiderosis and intratubular hemoglobin casts. Electron microscopy revealed features of glomerular microangiopathic injury. The treatment led to complete disease remission and a favorable renal outcome at the first year follow-up.

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Section: Discussionmentioning

confidence: 99%

“…Mycoplasma pneumoniae has been implicated as an etiology in various renal manifestations in both children and adults. Acute GN has been sporadically reported in association with M. pneumoniae infection [5][6][7] , while the combination of acute kidney failure and hemolytic anemia in the course of the infection has been character-…”

Section: Introductionmentioning

confidence: 99%

Acute Kidney Injury and Hemolytic Anemia Secondary to Mycoplasma pneumoniae Infection

Carrara

Abbate

Sabadini³

2017

Nephron

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“…However, the organism has also been detected by PCR from a kidney biopsy specimen of a child with membranoproliferative glomerulonephritis who also had elevated IgM (263) and by immunoperoxidase staining of kidney tissue of a patient with acute interstitial cystitis (264). Renal complications can be of great clinical importance since they can lead to renal failure (265,266).…”

Section: Extrapulmonary Manifestationsmentioning

confidence: 99%

Mycoplasma pneumoniae from the Respiratory Tract and Beyond

et al. 2017

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is an important cause of respiratory tract infections in children as well as adults that can range in severity from mild to life-threatening. Over the past several years there has been much new information published concerning infections caused by this organism. New molecular-based tests for detection are now commercially available in the United States, and advances in molecular typing systems have enhanced understanding of the epidemiology of infections. More strains have had their entire genome sequences published, providing additional insights into pathogenic mechanisms. Clinically significant acquired macrolide resistance has emerged worldwide and is now complicating treatment. susceptibility testing methods have been standardized, and several new drugs that may be effective against this organism are undergoing development. This review focuses on the many new developments that have occurred over the past several years that enhance our understanding of this microbe, which is among the smallest bacterial pathogens but one of great clinical importance.

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“…1 The identification of a previous case of acute postinfectious glomerulonephritis with transient hypocomplementemia (low serum C3 complement) associated with M. pneumoniae suggests transient complement activation. 15 The excessive activation of the alternative complement pathway results in endothelial cell injury and accumulation of the proinflammatory and procoagulant components that eventually trigger thrombosis. 1…”

Section: Discussionmentioning

confidence: 99%

Hemolytic Uremic Syndrome Caused by Mycoplasma Pneumoniae Infection in Children: A Case Report and Literature Review

Kittivisuit

Vachvanichsanong

Chotsampancharoen

2021

J Health Sci Med Res

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We describe the case of a 6-year-old boy with a Mycoplasma pneumoniae (M. pneumoniae) respiratory tract infection associated with thrombotic microangiopathic hemolytic anemia and thrombocytopenia with renal failure which was diagnosed as atypical hemolytic uremic syndrome. Renal biopsy showed features of thrombotic microangiopathy. The patient was treated with azithromycin for the M. pneumoniae infection, and supportive care with red cell transfusion and renal dialysis in the acute period. The microangiopathic hemolytic anemia and thrombocytopenia resolved within 2 months after diagnosis but the renal function damage was irreversible. The patient developed end-stage renal disease and required long term renal replacement therapy.

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Favorable outcome in a case of Mycoplasma pneumoniae-associated crescentic glomerulonephritis

Cited by 11 publications

References 14 publications

Acute Kidney Injury and Hemolytic Anemia Secondary to <b><i>Mycoplasma pneumoniae</i></b> Infection

Acute Kidney Injury and Hemolytic Anemia Secondary to <b><i>Mycoplasma pneumoniae</i></b> Infection

Mycoplasma pneumoniae from the Respiratory Tract and Beyond

Hemolytic Uremic Syndrome Caused by Mycoplasma Pneumoniae Infection in Children: A Case Report and Literature Review

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