Favorable outcome of Ewing sarcoma family tumors to multiagent intensive preoperative chemotherapy: A single institution experience

Moschovi, Maria; Trimis, Georgios; Stefanaki, Kalliopi; Anastasopoulos, John; Syriopoulou, Vassiliki; Koultouki, Eleutheria; Tzortzatou‐Stathopoulou, Fotini

doi:10.1002/jso.20206

Cited by 15 publications

(7 citation statements)

References 22 publications

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“…However, severe acute toxicities were more frequent in the BuMel group, and the incidence of secondary malignancies in long-term survivors was not reported. Studies on other agents are more limited, thus no firm conclusion could be drawn at this stage 40 – 43 . To date, there is no standard treatment for refractory disease.…”

Section: Discussionmentioning

confidence: 99%

Outcome of multidisciplinary treatment of peripheral primitive neuroectodermal tumor

Liu

Yuan

Zhang

et al. 2020

Sci Rep

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Peripheral primitive neuroectodermal tumors (PNETs) constitute very rare and aggressive malignancies. To date, there are no standard guidelines for management of peripheral PNETs due to the paucity of cases arising in various body sites. Therapeutic approach is derived from Ewing sarcoma family, which currently remains multimodal. Our study retrospectively analyzed 86 PNET patients from February 1, 1998 to February 1, 2018 at Peking Union Medical College Hospital with an additional 75 patients from review of literature. The clinicopathologic and treatment plans associated with survival was investigated. Surgery, chemotherapy, female sex, small tumor size, no lymph node metastasis, R0 surgical resection, (vincristine + doxorubicin + cyclophosphamide)/(isophosphamide + etoposide) regimen, and more than 10 cycles of chemotherapy were associated with improved overall survival in univariate analysis. Surgery, more than 10 cycles of chemotherapy, and small tumor size were independent prognostic factors for higher overall survival. Our data indicates that multimodal therapy is the mainstay therapeutic approach for peripheral PNET.

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Section: Discussionmentioning

confidence: 99%

Outcome of multidisciplinary treatment of peripheral primitive neuroectodermal tumor

Liu

Yuan

Zhang

et al. 2020

Sci Rep

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“…Moschovi et al [ 18 ] reported that the overall survival rate of patients with ES/PNET has progressively improved as a result of an effective systemic treatment and adequate resection and radiation for local control. Furthermore, the research suggested that multiagent intensive chemotherapy before surgery can further improve the prediction of these tumors.…”

Section: Discussionmentioning

confidence: 99%

Primitive Neuroectodermal Tumor of the Pancreas: A Case Report and Review of the Literature

Teixeira

Goldoni

Unterleider

et al. 2015

Case Reports in Surgery

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Primitive neuroectodermal tumors (PNETs) are presented as rare malignant neoplasms. In unusual cases, those neoplasms may arise in solid organs containing neuroendocrine cells, such as the pancreas. Herein the case of a 28-year-old patient that underwent gastroduodenopancreatectomy after the diagnosis of a huge mass (PNET) located in both head and body of the pancreas is reported. This is the 19th case of pancreatic PNET reported in literature.

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“…Chemotherapeutic agent tried in combination are vincristine, cyclophosphamide, actinomycin D and doxorubicin. [6] Prognosis is poor and depends on age of patient at the time of diagnosis, tumor bulk, location and prescence secondaries. In our case patient underwent distal pancreatectomy and splenectomy and received adjuvant chemo-radiotherapy, and after 26 months she died of multiple liver, bone and lung metastasis [7].…”

Section: Discussionmentioning

confidence: 99%

Pancreatic Ewings Sarcoma- A Dreadful Tumor

Jayant¹,

Agrawal²,

Agarwal³

et al. 2013

AJCP

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Extraosseous Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) is an uncommon, aggressive, and malignant tumor of poor prognosis. Pancreas in one of the very rare extraosseous location for this tumor thus very minimal information regarding this disorder is present in literature. The present case was clinically and radiologically misdiagnosed as a pancreatic tumor. Histopathology of the tumor tissue revealed "small round cells" that were positive for CD99 (MIC-2), confirming the diagnosis of ES/PNET. In young adults with intraabdominal, extraintestinal mass, Ewing's sarcoma must be kept as a differential diagnosis is our aim in presenting this case report.

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Favorable outcome of Ewing sarcoma family tumors to multiagent intensive preoperative chemotherapy: A single institution experience

Abstract: The intensive chemotherapy schedule, comprising of 5-6 cycles preoperatively, seems to maximize the percentage of tumor necrosis, thus improving outcome. Our study implies that this combined therapy may improve the prognosis of ESFT.

Cited by 15 publications

References 22 publications

Outcome of multidisciplinary treatment of peripheral primitive neuroectodermal tumor

Outcome of multidisciplinary treatment of peripheral primitive neuroectodermal tumor

Primitive Neuroectodermal Tumor of the Pancreas: A Case Report and Review of the Literature

Pancreatic Ewings Sarcoma- A Dreadful Tumor

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